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Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma

  • Authors:
    • Nobuki Furubayashi
    • Takahito Negishi
    • Dai Takamatsu
    • Kosuke Ieiri
    • Tomohiro Inoue
    • Keiji Tsukino
    • Motonobu Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811‑1395, Japan
    Copyright: © Furubayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2943-2949
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    Published online on: February 5, 2020
       https://doi.org/10.3892/ol.2020.11368
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Abstract

Cisplatin‑based systemic chemotherapy is the gold‑standard approach for the first‑line treatment of patients with advanced or metastatic urothelial carcinoma (UC). However, the optimal number of cycles is still unclear. The current study retrospectively assessed the clinical outcome in patients who received gemcitabine and cisplatin (GC) chemotherapy as first‑line treatment for metastatic urothelial cancer to clarify the timing of switching from GC therapy. A total of 61 patients with locally advanced or metastatic UC who received first‑line chemotherapy with GC were retrospectively reviewed at National Hospital Organization Kyushu Cancer Center between June 2009 and August 2017. The progression‑free survival (PFS) and overall survival (OS) were evaluated using the Kaplan‑Meier method. The significance of associations between the clinical parameters and OS was assessed using the Cox proportional hazards regression model. The median cycle number for GC chemotherapy was 4. The median PFS and OS of all cases was 5.2 and 14.1 months, respectively. The multivariate analyses revealed that a neutrophil‑to‑lymphocyte ratio ≥3.0 (hazard ratio [HR], 2.521, 95% confidence interval [CI]=1.179‑5.624; P=0.017) and best response to GC therapy of CR+PR (HR 0.110; 95% CI=0.028‑0.411; P<0.001) were independent prognostic factors. However, the number of GC cycles (≤4 vs. >4) was not an independent prognostic factor (P=0.387). The current retrospective study indicated that changes to therapy should be considered at an early stage for cases with a therapeutic effect of SD or less, regardless of the number of GC therapy cycles.
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Copy and paste a formatted citation
Spandidos Publications style
Furubayashi N, Negishi T, Takamatsu D, Ieiri K, Inoue T, Tsukino K and Nakamura M: Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma. Oncol Lett 19: 2943-2949, 2020.
APA
Furubayashi, N., Negishi, T., Takamatsu, D., Ieiri, K., Inoue, T., Tsukino, K., & Nakamura, M. (2020). Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma. Oncology Letters, 19, 2943-2949. https://doi.org/10.3892/ol.2020.11368
MLA
Furubayashi, N., Negishi, T., Takamatsu, D., Ieiri, K., Inoue, T., Tsukino, K., Nakamura, M."Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma". Oncology Letters 19.4 (2020): 2943-2949.
Chicago
Furubayashi, N., Negishi, T., Takamatsu, D., Ieiri, K., Inoue, T., Tsukino, K., Nakamura, M."Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma". Oncology Letters 19, no. 4 (2020): 2943-2949. https://doi.org/10.3892/ol.2020.11368
Copy and paste a formatted citation
x
Spandidos Publications style
Furubayashi N, Negishi T, Takamatsu D, Ieiri K, Inoue T, Tsukino K and Nakamura M: Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma. Oncol Lett 19: 2943-2949, 2020.
APA
Furubayashi, N., Negishi, T., Takamatsu, D., Ieiri, K., Inoue, T., Tsukino, K., & Nakamura, M. (2020). Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma. Oncology Letters, 19, 2943-2949. https://doi.org/10.3892/ol.2020.11368
MLA
Furubayashi, N., Negishi, T., Takamatsu, D., Ieiri, K., Inoue, T., Tsukino, K., Nakamura, M."Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma". Oncology Letters 19.4 (2020): 2943-2949.
Chicago
Furubayashi, N., Negishi, T., Takamatsu, D., Ieiri, K., Inoue, T., Tsukino, K., Nakamura, M."Timing of changing therapy from gemcitabine and cisplatin chemotherapy based on real‑world data of advanced urothelial carcinoma". Oncology Letters 19, no. 4 (2020): 2943-2949. https://doi.org/10.3892/ol.2020.11368
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