Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2020 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2020 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma

  • Authors:
    • Yan Zhao
    • Wen‑Li Cui
    • Zhi‑Yin Feng
    • Jing Xue
    • Abulajiang Gulinaer
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Xinjiang, Urumqi 830011, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2755-2764
    |
    Published online on: February 6, 2020
       https://doi.org/10.3892/ol.2020.11374
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The most specific biomarker on the surface of regulatory T cells (Tregs) is the forkhead/wingeded‑helix protein 3 (Foxp3). In contrast, the expression of interleukin‑7 receptor (IL‑7R) is low or negative in Tregs. The present study aimed to investigate the expression of Foxp3 and IL‑7R in diffuse large B‑cell lymphoma (DLBCL), and to analyse the clinicopathological characteristics of patients with DLBCL and their association with overall survival (OS). Immunohistochemistry was performed to detect the expression of Foxp3 and IL‑7R on routinely processed formalin‑fixed and paraffin‑embedded specimens. The χ2 test was used to analyse the association between the expression of Foxp3 and IL‑7R and the clinicopathological characteristics of patients with DLBCL. Survival curves were used to investigate the effect of Foxp3 and IL‑7R on patient prognosis. The results demonstrated that high Foxp3 expression in tissue was associated with non‑ germinal centre B‑cell (GCB)‑type disease (P=0.012), International Prognostic Index score >0 (P=0.012), stage 3 or 4 tumour (P=0.045) and disease progression and stabilization period (P=0.032). In addition, IL‑7R expression was associated with non‑GCB‑type disease (P=0.001) and extranodal lymphoma (P=0.008). Furthermore, expression of Foxp3 and IL‑7R was not associated with OS (P=0.447 and P=0.201, respectively). Foxp3 and IL‑7R expression in non‑GCB‑type lymphoma was significantly higher compared with that in GCB lymphoma. The expression of Foxp3 and IL‑7R may therefore help the development of individualized treatment, prognostic prediction and therapy stratification.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Herreros B, Sanchez-Aguilera A and Piris MA: Lymphoma microenvironment: Culprit or innocent? Leukemia. 22:49–58. 2008. View Article : Google Scholar : PubMed/NCBI

2 

A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project. Blood. 89:3909–3918. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Krol AD, le Cessie S, Snijder S, Kluin-Nelemans JC, Kluin PM and Noordijk EM: Primary extranodal non-Hodgkin's lymphoma (NHL): The impact of alternative definitions tested in the Comprehensive cancer centre west population-based NHL registry. Ann Oncol. 14:131–139. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Chiu BC and Hou N: Epidemiology and etiology of non-hodgkin lymphoma. Cancer Treat Res. 165:1–25. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Hamlin PA, Satram-Hoang S, Reyes C, Hoang KQ, Guduru SR and Skettino S: Treatment patterns and comparative effectiveness in elderly diffuse large B-cell lymphoma patients: A surveillance, epidemiology, and end results-medicare analysis. Oncologist. 19:1249–1257. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD and Jaffe ES: The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–2390. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Yim SK, Yhim HY, Han YH, Jeon SY, Lee NR, Song EK, Jeong HJ, Kim HS and Kwak JY: Early risk stratification for diffuse large B-cell lymphoma integrating interim Deauville score and International Prognostic Index. Ann Hematol. 98:2739–2748. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Farinha P, Al-Tourah A, Gill K, Klasa R, Connors JM and Gascoyne RD: The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation. Blood. 115:289–295. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Mailloux AW and Young MR: Regulatory T-cell trafficking: From thymic development to tumor-induced immune suppression. Crit Rev Immunol. 30:435–447. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Wang K and Vella AT: Regulatory T cells and cancer: A two-sided story. Immunol Invest. 45:797–812. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, et al: CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg cells. J Exp Med. 203:1701–1711. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Wang H, Pan K and Xia JC: Interaction of indoleamine-2,3-dioxyagnase and CD4+CD25+ regulatory T cells in tumor immune escape. Ai Zheng. 28:184–187. 2009.PubMed/NCBI

13 

Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H and Jaffe ES: The 2008 WHO classification of lymphoid neoplasms and beyond: Evolving concepts and practical applications. Blood. 117:5019–5032. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Cui W, Zheng S, Liu Z, Wang W, Cai Y, Bi R, Cao B and Zhou X: PIK3CA expression in diffuse large B cell lymphoma tissue and the effect of its knockdown in vitro. Onco Targets Ther. 10:2239–2247. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Cui W, Cai Y, Wang W, Liu Z, Wei P, Bi R, Chen W, Sun M and Zhou X: Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma. J Transl Med. 12:102014. View Article : Google Scholar : PubMed/NCBI

16 

Keane C, Gould C, Jones K, Hamm D, Talaulikar D, Ellis J, Vari F, Birch S, Han E, Wood P, et al: The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma. Clin Cancer Res. 23:1820–1828. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Gomez-Gelvez JC, Salama ME, Perkins SL, Leavitt M and Inamdar KV: Prognostic impact of tumor microenvironment in diffuse large b-cell lymphoma uniformly treated with R-chop chemotherapy. Am J Clin Pathol. 145:514–523. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Zhang J, Wei B, Hu H, Liu F, Tu Y, Zhao M and Wu D: Preliminary study on decreasing the expression of FOXP3 with miR-155 to inhibit diffuse large B-cell lymphoma. Oncol Lett. 14:1711–1718. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Hinz S, Pagerols-Raluy L, Oberg HH, Ammerpohl O, Grüssel S, Sipos B, Grützmann R, Pilarsky C, Ungefroren H, Saeger HD, et al: Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res. 67:8344–8350. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MW, et al: FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell. 129:1275–1286. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Wang LH, Su L and Wang JT: Correlation between elevated FOXP3 expression and increased lymph node metastasis of gastric cancer. Chin Med J (Engl). 123:3545–3549. 2010.PubMed/NCBI

22 

Triulzi T, Tagliabue E, Balsari A and Casalini P: FOXP3 expression in tumor cells and implications for cancer progression. J Cell Physiol. 228:30–35. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Kinoshita F, Takada K, Yamada Y, Oku Y, Kosai K, Ono Y, Tanaka K, Wakasu S, Oba T, Osoegawa A, et al: Combined evaluation of tumor-infiltrating cd8 + and foxp3 + lymphocytes provides accurate prognosis in stage ia lung adenocarcinoma. Ann Surg Oncol. 262019.(Epub ahead of print).

24 

Zhao X, Li Y, Wang X, Wu J, Yuan Y, Lv S and Ren J: Synergistic association of FOXP3+ tumor infiltrating lymphocytes with CCL20 expressions with poor prognosis of primary breast cancer: A retrospective cohort study. Medicine (Baltimore). 98:e184032019. View Article : Google Scholar : PubMed/NCBI

25 

Shang B and Liu Y, Jiang SJ and Liu Y: Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: A systematic review and meta-analysis. Sci Rep. 5:151792015. View Article : Google Scholar : PubMed/NCBI

26 

Katoh H, Zheng P and Liu Y: Signalling through FOXP3 as an X-linked tumor suppressor. Int J Biochem Cell Biol. 42:1784–1787. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Won KY, Kim GY, Kim HK, Choi SIl, Kim SH, Bae GE, Lim JU and Lim SJ: Tumoral FOXP3 expression is associated with favorable clinicopathological variables and good prognosis in gastric adenocarcinoma: The tumor suppressor function of tumoral FOXP3 is related with the P21 expression in gastric adenocarcinoma. Hum Pathol. 68:112–118. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Hu G, Li Z and Wang S: Tumor-infiltrating FoxP3(+) Tregs predict favorable outcome in colorectal cancer patients: A meta-analysis. Oncotarget. 8:75361–75371. 2017.PubMed/NCBI

29 

Wang X, Lang M, Zhao T, Feng X, Zheng C, Huang C, Hao J, Dong J, Luo L and Li X: Cancer-FOXP3 directly activated CCL5 to recruit FOXP3(+)Treg cells in pancreatic ductal adenocarcinoma. Oncogene. 36:3048–3058. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Zhang L, Xu J, Zhang X, Zhang Y, Wang L, Huang X and Xu Z: The role of tumoral foxp3 on cell proliferation, migration, and invasion in gastric cancer. Cell Physiol Biochem. 42:1739–1754. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Berglund M, Thunberg U, Amini RM, Book M, Erlanson M, Linderoth J, Dictor M, Jerkeman M, Cavallin-Ståhl E, Sundström C, et al: Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis. Mod Pathol. 18:1113–1120. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Nakayama S, Yokote T, Akioka T, Hiraoka N, Nishiwaki U, Miyoshi T, Iwaki K, Takayama A, Masuda Y, Hatooka J, et al: Infiltration of effector regulatory T cells predicts poor prognosis of diffuse large B-cell lymphoma, not otherwise specified. Blood Adv. 1:486–493. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Fry TJ and Mackall CL: The many faces of IL-7: From lymphopoiesis to peripheral T cell maintenance. J Immunol. 174:6571–6576. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Qin JZ, Zhang CL, Kamarashev J, Dummer R, Burg G and Dobbeling U: Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. Blood. 98:2778–2783. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Takakuwa T, Nomura S, Matsuzuka F, Inoue H and Aozasa K: Expression of interleukin-7 and its receptor in thyroid lymphoma. Lab Invest. 80:1483–1490. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Sasson SC, Smith S, Seddiki N, Zaunders JJ, Bryant A, Koelsch KK, Weatherall C, Munier ML, McGinley C, Yeung J, et al: IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers. Cytokine. 50:58–68. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Al-Rawi MA, Mansel RE and Jiang WG: Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours. Histol Histopathol. 18:911–923. 2003.PubMed/NCBI

38 

Görgün G, van der Spek J, Cosenza L, Menevse A and Foss F: Altered biological activity associated with C-terminal modifications of IL-7. Cytokine. 20:17–22. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Heninger AK, Theil A, Wilhelm C, Petzold C, Huebel N, Kretschmer K, Bonifacio E and Monti P: IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol. 189:5649–5658. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Coiffier B and Sarkozy C: Diffuse large B-cell lymphoma: R-CHOP failure-what to do? Hematology Am Soc Hematol Educ Program. 2016:366–378. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Cui WL, Feng ZY, Xue J, Gulinaer A and Zhang W: Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma. Oncol Lett 19: 2755-2764, 2020.
APA
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., & Zhang, W. (2020). Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma. Oncology Letters, 19, 2755-2764. https://doi.org/10.3892/ol.2020.11374
MLA
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., Zhang, W."Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma". Oncology Letters 19.4 (2020): 2755-2764.
Chicago
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., Zhang, W."Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma". Oncology Letters 19, no. 4 (2020): 2755-2764. https://doi.org/10.3892/ol.2020.11374
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Cui WL, Feng ZY, Xue J, Gulinaer A and Zhang W: Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma. Oncol Lett 19: 2755-2764, 2020.
APA
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., & Zhang, W. (2020). Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma. Oncology Letters, 19, 2755-2764. https://doi.org/10.3892/ol.2020.11374
MLA
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., Zhang, W."Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma". Oncology Letters 19.4 (2020): 2755-2764.
Chicago
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., Zhang, W."Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma". Oncology Letters 19, no. 4 (2020): 2755-2764. https://doi.org/10.3892/ol.2020.11374
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team