Open Access

Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma

  • Authors:
    • Yan Zhao
    • Wen‑Li Cui
    • Zhi‑Yin Feng
    • Jing Xue
    • Abulajiang Gulinaer
    • Wei Zhang
  • View Affiliations

  • Published online on: February 6, 2020     https://doi.org/10.3892/ol.2020.11374
  • Pages: 2755-2764
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The most specific biomarker on the surface of regulatory T cells (Tregs) is the forkhead/wingeded‑helix protein 3 (Foxp3). In contrast, the expression of interleukin‑7 receptor (IL‑7R) is low or negative in Tregs. The present study aimed to investigate the expression of Foxp3 and IL‑7R in diffuse large B‑cell lymphoma (DLBCL), and to analyse the clinicopathological characteristics of patients with DLBCL and their association with overall survival (OS). Immunohistochemistry was performed to detect the expression of Foxp3 and IL‑7R on routinely processed formalin‑fixed and paraffin‑embedded specimens. The χ2 test was used to analyse the association between the expression of Foxp3 and IL‑7R and the clinicopathological characteristics of patients with DLBCL. Survival curves were used to investigate the effect of Foxp3 and IL‑7R on patient prognosis. The results demonstrated that high Foxp3 expression in tissue was associated with non‑ germinal centre B‑cell (GCB)‑type disease (P=0.012), International Prognostic Index score >0 (P=0.012), stage 3 or 4 tumour (P=0.045) and disease progression and stabilization period (P=0.032). In addition, IL‑7R expression was associated with non‑GCB‑type disease (P=0.001) and extranodal lymphoma (P=0.008). Furthermore, expression of Foxp3 and IL‑7R was not associated with OS (P=0.447 and P=0.201, respectively). Foxp3 and IL‑7R expression in non‑GCB‑type lymphoma was significantly higher compared with that in GCB lymphoma. The expression of Foxp3 and IL‑7R may therefore help the development of individualized treatment, prognostic prediction and therapy stratification.
View Figures
View References

Related Articles

Journal Cover

April-2020
Volume 19 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Cui WL, Feng ZY, Xue J, Gulinaer A and Zhang W: Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma. Oncol Lett 19: 2755-2764, 2020
APA
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., & Zhang, W. (2020). Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma. Oncology Letters, 19, 2755-2764. https://doi.org/10.3892/ol.2020.11374
MLA
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., Zhang, W."Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma". Oncology Letters 19.4 (2020): 2755-2764.
Chicago
Zhao, Y., Cui, W., Feng, Z., Xue, J., Gulinaer, A., Zhang, W."Expression of Foxp3 and interleukin‑7 receptor and clinicopathological characteristics of patients with diffuse large B‑cell lymphoma". Oncology Letters 19, no. 4 (2020): 2755-2764. https://doi.org/10.3892/ol.2020.11374