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BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer

  • Authors:
    • Xin Wang
    • Yumei Xu
    • Kun Xu
    • Yajuan Chen
    • Xiudi Xiao
    • Xiaoxiang Guan
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, P.R. China, Department of Gynaecology and Obstetrics, Zhongshan People's Hospital, Zhongshan, Guangdong 528403, P.R. China, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Medical Oncology, Jinling Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China, Department of Breast Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2916-2924
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    Published online on: February 10, 2020
       https://doi.org/10.3892/ol.2020.11383
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Abstract

Triple‑negative breast cancer (TNBC) is associated with poor clinical prognosis due to a lack of effective therapeutic options. The expression of B‑cell lymphoma/leukemia 11A (BCL11A) has been indicated to correlate with TNBC carcinogenesis, though the precise mechanisms of BCL11A‑induced tumorigenesis in TNBC remain unclear. Using data retrieved from The Cancer Genome Atlas (TCGA) database, the present study demonstrated that BCL11A expression was upregulated in TNBC, compared with other types of breast cancer. Furthermore, in a tissue microarray of 140 patients with breast cancer, an elevated BCL11A level was correlated with unfavorable overall survival (OS), and exogenous BCL11A‑knockdown was subsequently verified to inhibit tumor growth and metastasis in TNBC. Notably, the same tissue microarray revealed that a favorable patient outcome was associated with high expression levels of BCL11A and androgen receptor (AR). Moreover, BCL11A‑knockdown significantly inhibited the expression level of AR and further had an influence on proliferation, migration and invasion in TNBC cell lines. Collectively, the results of the current study indicate the function of BCL11A in TNBC progression, and provide new insights into the unique mechanism of BCL11A in AR regulation, emphasizing the significance of more research on BCL11A and AR regulation in TNBC molecular treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Xu Y, Xu K, Chen Y, Xiao X and Guan X: BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer. Oncol Lett 19: 2916-2924, 2020.
APA
Wang, X., Xu, Y., Xu, K., Chen, Y., Xiao, X., & Guan, X. (2020). BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer. Oncology Letters, 19, 2916-2924. https://doi.org/10.3892/ol.2020.11383
MLA
Wang, X., Xu, Y., Xu, K., Chen, Y., Xiao, X., Guan, X."BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer". Oncology Letters 19.4 (2020): 2916-2924.
Chicago
Wang, X., Xu, Y., Xu, K., Chen, Y., Xiao, X., Guan, X."BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer". Oncology Letters 19, no. 4 (2020): 2916-2924. https://doi.org/10.3892/ol.2020.11383
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Xu Y, Xu K, Chen Y, Xiao X and Guan X: BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer. Oncol Lett 19: 2916-2924, 2020.
APA
Wang, X., Xu, Y., Xu, K., Chen, Y., Xiao, X., & Guan, X. (2020). BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer. Oncology Letters, 19, 2916-2924. https://doi.org/10.3892/ol.2020.11383
MLA
Wang, X., Xu, Y., Xu, K., Chen, Y., Xiao, X., Guan, X."BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer". Oncology Letters 19.4 (2020): 2916-2924.
Chicago
Wang, X., Xu, Y., Xu, K., Chen, Y., Xiao, X., Guan, X."BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer". Oncology Letters 19, no. 4 (2020): 2916-2924. https://doi.org/10.3892/ol.2020.11383
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