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Article Open Access

CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer

  • Authors:
    • Junying Wang
    • Xiaoping Yang
    • Shixin Han
    • Lizhi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Anesthesiology, Dalian Obstetrics and Gynecology Hospital, Dalian, Liaoning 116033, P.R. China, Department of Dermatology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3145-3152
    |
    Published online on: February 19, 2020
       https://doi.org/10.3892/ol.2020.11411
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Abstract

Disrupted centrosome‑associated family protein expression can result in the detrimental duplication of centrosomes, causing genomic instability and subsequent carcinogenesis. Limited research has demonstrated that centrosomal protein 131 (CEP131) exhibits oncogenic activity in osteosarcoma, hepatocellular carcinoma and breast cancer. The present study demonstrated that there is an association between CEP131 expression and advanced Tumor‑Node‑Metastasis stage (P=0.016), and positive regional lymph node metastasis (P=0.023) in 91 cases of non‑small cell lung cancer. A549 and SPC‑A‑1 cells, with moderate expression levels of CEP131, were selected as representative cell lines. The results indicated that downregulation of CEP131 induced G1/S cell cycle arrest, inhibition of cyclins D1/E and cyclin‑dependent kinases 2/4/6, and induction of inhibitory p21/p27, all of which are regulated by ERK and AKT signaling, suggesting that CEP131 exhibits potential as a novel target in the treatment of lung cancer.
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1 

Baker MJ, Cooke M and Kazanietz MG: Nuclear PKCl-ECT2-Rac1 and ribosome biogenesis: A novel axis in lung tumorigenesis. Cancer Cell. 31:167–169. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Wu DW, Chen TC, Huang HS and Lee H: TC-N19, a novel dual inhibitor of EGFR and cMET, efficiently overcomes EGFR-TKI resistance in non-small-cell lung cancer cells. Cell Death Dis. 7:e22902016. View Article : Google Scholar : PubMed/NCBI

3 

Zhang X, Yu X, Jiang G, Miao Y, Wang L, Zhang Y, Liu Y, Fan C, Lin X, Dong Q, et al: Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. Cancer Res. 75:4527–4537. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Wei CC, Nie FQ, Jiang LL, Chen QN, Chen ZY, Chen X, Pan X, Liu ZL, Lu BB and Wang ZX: The pseudogene DUXAP10 promotes an aggressive phenotype through binding with LSD1 and repressing LATS2 and RRAD in non small cell lung cancer. Oncotarget. 8:5233–5246. 2017.PubMed/NCBI

5 

Kumar A, Rajendran V, Sethumadhavan R and Purohit R: CEP proteins: The knights of centrosome dynasty. Protoplasma. 250:965–983. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Aoto H, Tsuchida J, Nishina Y, Nishimune Y, Asano A and Tajima S: Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids. Eur J Biochem. 234:8–15. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Aoto H, Miyake Y, Nakamura M and Tajima S: Genomic organization of the mouse AZ1 gene that encodes the protein localized to preacrosomes of spermatids. Genomics. 40:138–141. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA and Mann M: Proteomic characterization of the human centrosome by protein correlation profiling. Nature. 426:570–574. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Ma L and Jarman AP: Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation. J Cell Sci. 124:2622–2630. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Staples CJ, Myers KN, Beveridge RD, Patil AA, Lee AJ, Swanton C, Howell M, Boulton SJ and Collis SJ: The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci. 125:4770–4779. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Tollenaere MAX, Villumsen BH, Blasius M, Nielsen JC, Wagner SA, Bartek J, Beli P, Mailand N and Bekker-Jensen S: p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1. Nat Commun. 6:100752015. View Article : Google Scholar : PubMed/NCBI

12 

Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, et al: USP9X regulates centrosome duplication and promotes breast carcinogenesis. Nat Commun. 8:148662017. View Article : Google Scholar : PubMed/NCBI

13 

Liu XH, Yang YF, Fang HY, Wang XH, Zhang MF and Wu DC: CEP131 indicates poor prognosis and promotes cell proliferation and migration in hepatocellular carcinoma. Int J Biochem Cell Biol. 90:1–8. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, et al: The 2015 World Health Organization classification of lung tumors: Impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol. 10:1243–1260. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Wang H, Yu Z, Huo S, Chen Z, Ou Z, Mai J, Ding S and Zhang J: Overexpression of ELF3 facilitates cell growth and metastasis through PI3K/Akt and ERK signaling pathways in non-small cell lung cancer. Int J Bio Cell Bio. 94:98–106. 2018. View Article : Google Scholar

16 

Zhao J, Ou B, Han D, Wang P, Zong Y, Zhu C, Liu D, Zheng M, Sun J, Feng H and Lu A: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways. Mol Cancer. 16:702017. View Article : Google Scholar : PubMed/NCBI

17 

Wang Y, Nie H, Zhao X, Qin Y and Gong X: Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways. BMC Cancer. 16:7422016. View Article : Google Scholar : PubMed/NCBI

18 

Hall JR, Messenger ZJ, Tam HW, Phillips SL, Recio L and Smart RC: Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell Death Dis. 6:e17002015. View Article : Google Scholar : PubMed/NCBI

19 

Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, et al: CMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res. 25:429–444. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Mizuno H, Nakanishi Y, Ishii N, Sarai A and Kitada K: A signature-based method for indexing cell cycle phase distribution from microarray profiles. BMC Genomics. 10:1372009. View Article : Google Scholar : PubMed/NCBI

21 

Sherr CJ and Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–1512. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Tashima Y, Hamada H, Okamoto M and Hanai T: Prediction of key factor controlling G1/S phase in the mammalian cell cycle using system analysis. J Biosci Bioeng. 106:368–374. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Sherr CJ: Mammalian G1 cyclins. Cell. 73:1059–1065. 1993. View Article : Google Scholar : PubMed/NCBI

24 

Donnellan R and Chetty R: Cyclin D1 and human neoplasia. Mol Pathol. 51:1–7. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Zuryn A, Litwiniec A, Safiejko-Mroczka B, Klimaszewska-Wiśniewska A, Gagat M, Krajewski A, Gackowska L and Grzanka D: The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line. Int J Oncol. 48:2521–2533. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhang X, Wu J, Luo S, Lechler T and Zhang JY: FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. Oncotarget. 23:34371–34383. 2016.

27 

Wang Y, Liu J, Cui J, Xing L, Wang J, Yan X and Zhang X: ERK and p38 MAPK signalling pathways are involved in ochratoxin A-induced G2 phase arrest in human gastric epithelium cells. Toxicol Lett. 209:186–192. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Shao Q, Han F, Peng S and He B: Nur77 inhibits oxLDL induced apoptosis of macrophages via the p38 MAPK signalling pathway. Biochem Biophys Res Commun. 471:633–638. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Chien CC, Wu MS, Shen SC, Ko CH, Chen CH, Yang LL and Chen YC: Activation of JNK contributes to evodiamineinduced apoptosis and G2/M arrest in human colorectal carcinoma cells: A structure-activity study of evodiamine. PLoS One. 9:e997292014. View Article : Google Scholar : PubMed/NCBI

30 

Tsai WB, Aiba I, Long Y, Lin HK, Feun L, Savaraj N and Kuo MT: Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells. Cancer Res. 72:2622–2633. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Saiprasad G, Chitra P, Manikandan R and Sudhandiran G: Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Eur J Cancer. 50:2489–2507. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Wen W, Ding J, Sun W, Fu J, Chen Y, Wu K, Ning B, Han T, Huang L, Chen C, et al: Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression. Hepatology. 55:1787–1798. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yang X, Han S and Zhang L: CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer. Oncol Lett 19: 3145-3152, 2020.
APA
Wang, J., Yang, X., Han, S., & Zhang, L. (2020). CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer. Oncology Letters, 19, 3145-3152. https://doi.org/10.3892/ol.2020.11411
MLA
Wang, J., Yang, X., Han, S., Zhang, L."CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer". Oncology Letters 19.4 (2020): 3145-3152.
Chicago
Wang, J., Yang, X., Han, S., Zhang, L."CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer". Oncology Letters 19, no. 4 (2020): 3145-3152. https://doi.org/10.3892/ol.2020.11411
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Yang X, Han S and Zhang L: CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer. Oncol Lett 19: 3145-3152, 2020.
APA
Wang, J., Yang, X., Han, S., & Zhang, L. (2020). CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer. Oncology Letters, 19, 3145-3152. https://doi.org/10.3892/ol.2020.11411
MLA
Wang, J., Yang, X., Han, S., Zhang, L."CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer". Oncology Letters 19.4 (2020): 3145-3152.
Chicago
Wang, J., Yang, X., Han, S., Zhang, L."CEP131 knockdown inhibits cell proliferation by inhibiting the ERK and AKT signaling pathways in non‑small cell lung cancer". Oncology Letters 19, no. 4 (2020): 3145-3152. https://doi.org/10.3892/ol.2020.11411
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