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Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus

  • Authors:
    • Mengge Li
    • Yalin Zhao
    • Xiaoli Liu
    • Shuan Zhang
    • Yuyong Jiang
    • Zhiyun Yang
  • View Affiliations / Copyright

    Affiliations: Center for Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China, Department of Gastroenterology and Hematology Medicine, People's Hospital of Hebi, Hebi, Henan 450000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3249-3257
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    Published online on: March 3, 2020
       https://doi.org/10.3892/ol.2020.11423
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Abstract

Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)‑associated primary HCC (HBV‑HCC) with PVTT. Data from 346 patients (263 and 83 in the modeling and validation cohorts, respectively) who had received primary diagnoses of HBV‑HCC and PVTT between January 2012 and June 2015 at Beijing Ditan Hospital (Beijing, China) were retrospectively examined. In the modeling cohort, univariate and multivariate logistic regression analyses were conducted to determine the factors that were significantly associated with distant metastasis. Furthermore, an early risk warning model for distant metastasis was proposed and validated through receiver operating characteristic curve analysis in the validation cohort. The results revealed that neutrophil to lymphocyte ratios of ≥2.31, red blood cell counts of ≥4.07x1012 cells/l, C‑reactive protein levels of ≥7.02 mg/l, aspartate aminotransferase levels of ≥118.5 U/l and tumor thrombus site (at branch) were significantly positively associated with distant metastasis of HBV‑HCC with PVTT (P<0.05; odds ratio >1.000). A formula for predicting distant metastasis was obtained with an accuracy of ~70%. The results of the present study may allow for the early prediction of distant metastasis and facilitate the administration of appropriate treatment to improve the outcomes and prognosis of patients with intermediate to advanced HCC.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, Zhang Y, Liu J, Gong X, Chen Y, et al: Reprint of: Epidemiological serosurvey of Hepatitis B in China-declining HBV prevalence due to Hepatitis B vaccination. Vaccine. 31 (Suppl 9):J21–J28. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Cui Y and Jia J: Update on epidemiology of hepatitis B and C in China. J Gastroenterol Hepatol. 28 (Suppl 1):S7–S10. 2013. View Article : Google Scholar

4 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Bruix J and Sherman M; Practice Guidelines Committee, : American Association for the Study of Liver Diseases: Management of hepatocellular carcinoma. Hepatology. 42:1208–1236. 2015. View Article : Google Scholar

6 

Bruix J and Sherman M; American Association for the Study of Liver Diseases, : Management of hepatocellular carcinoma: An update. Hepatology. 53:1020–1022. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Addario L, Tritto G, Cavaglià E, Amodio F, Giannelli E and Di Costanzo GG: Preserved liver function, portal thrombosis and absence of oesophageal varices are risk factors for metastasis of hepatocellular carcinoma. Dig Liver Dis. 43:319–324. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Zhang ZM, Lai EC, Zhang C, Yu HW, Liu Z, Wan BJ, Liu LM, Tian ZH, Deng H, Sun QH and Chen XP: The strategies for treating primary hepatocellular carcinoma with portal vein tumor thrombus. Int J Surg. 20:8–16. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Kokudo T, Hasegawa K, Matsuyama Y, Takayama T, Izumi N, Kadoya M, Kudo M, Ku Y, Sakamoto M, Nakashima O, et al: Survival benefit of liver resection for hepatocellular carcinoma associated with portal vein invasion. J Hepatol. 65:938–943. 2016. View Article : Google Scholar : PubMed/NCBI

10 

European Association for the Study of the Liver. Electronic address, . easloffice@easloffice.eu; European Association for the Study of the Liver: EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 67:370–398. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Okamura Y, Sugiura T, Ito T, Yamamoto Y, Ashida R, Mori K and Uesaka K: Neutrophil to lymphocyte ratio as an indicator of the malignant behaviour of hepatocellular carcinoma. Br J Surg. 103:891–898. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Lu SD, Wang YY, Peng NF, Peng YC, Zhong JH, Qin HG, Xiang BD, You XM, Ma L and Li LQ: Preoperative ratio of neutrophils to lymphocytes predicts postresection survival in selected patients with early or intermediate stage hepatocellular carcinoma. Medicine (Baltimore). 95:e27222016. View Article : Google Scholar : PubMed/NCBI

13 

Liu X, He L, Han J, Wang L, Li M, Jiang Y, Wang X and Yang Z: Association of neutrophil-lymphocyte ratio and T lymphocytes with the pathogenesis and progression of HBV-associated primary liver cancer. PLoS One. 12:e01706052017. View Article : Google Scholar : PubMed/NCBI

14 

Pawarode A, Voravud N, Sriuranpong V, Kullavanijaya P and Patt YZ: Natural history of untreated primary hepatocellular carcinoma: A retrospective study of 157 patients. Am J Clin Oncol. 21:386–391. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Tawada A, Chiba T, Ooka Y, Kanogawa N, Motoyama T, Saito T, Ogasawara S, Suzuki E, Maruyama H, Kanai F, et al: Efficacy of transarterial chemoembolization targeting portal vein tumor thrombus in patients with hepatocellular carcinoma. Anticancer Res. 34:4231–4237. 2014.PubMed/NCBI

16 

Villa E, Moles A, Ferretti I, Buttafoco P, Grottola A, Del Buono M, De Santis M and Manenti F: Natural history of inoperable hepatocellular carcinoma: Estrogen receptors' status in the tumor is the strongest prognostic factor for survival. Hepatology. 32:233–238. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Huang M, Lin Q, Wang H, Chen J, Bai M, Wang L, Zhu K, Jiang Z, Guan S, Li Z, et al: Survival benefit of chemoembolization plus Iodine125 seed implantation in unresectable hepatitis B-related hepatocellular carcinoma with PVTT: A retrospective matched cohort study. Eur Radiol. 26:3428–3436. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Byeon J, Cho EH, Kim SB and Choi DW: Extrahepatic recurrence of hepatocellular carcinoma after curative hepatic resection. Korean J Hepatobiliary Pancreat Surg. 16:93–97. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Jun L, Zhenlin Y, Renyan G, Yizhou W, Xuying W, Feng X, Yong X, Kui W, Jian L, Dong W, et al: Independent factors and predictive score for extrahepatic metastasis of hepatocellular carcinoma following curative hepatectomy. Oncologist. 17:963–969. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Morimoto Y, Nouso K, Wada N, Takeuchi Y, Kinugasa H, Miyahara K, Yasunaka T, Kuwaki K, Onishi H, Ikeda F, et al: Involvement of platelets in extrahepatic metastasis of hepatocellular carcinoma. Hepatol Res. 44:E353–E359. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Lee CH, Lin YJ, Lin CC, Yen CL, Shen CH, Chang CJ and Hsieh SY: Pretreatment platelet count early predicts extrahepatic metastasis of human hepatoma. Liver Int. 35:2327–2336. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Jang WS, Cho KS, Kim MS, Yoon CY, Kang DH, Kang YJ, Jeong WS, Ham WS and Choi YD: The prognostic significance of postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for localized prostate cancer. Oncotarget. 8:11778–11787. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Duan RD and Nilsson A: Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development. Prog Lipid Res. 48:62–72. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Paramanathan A, Saxena A and Morris DL: A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours. Surg Oncol. 23:31–39. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Qin M, Brummel S, Singh KK, Fenton T and Spector SA: Associations of host genetic variants on CD4+ lymphocyte count and plasma HIV-1 RNA in antiretroviral naïve children. Pediatr Infect Dis J. 33:946–952. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Xie X, Yao M, Chen X, Lu W, Lv Q, Wang K, Zhang L and Lu F: Reduced red blood cell count predicts poor survival after surgery in patients with primary liver cancer. Medicine (Baltimore). 94:e5772015. View Article : Google Scholar : PubMed/NCBI

27 

Noy R and Pollard JW: Tumor-associated macrophages: From mechanisms to therapy. Immunity. 41:49–61. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, Rey-Giraud F, Pradel LP, Feuerhake F, Klaman I, et al: Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell. 25:846–859. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Tang X: Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer. Cancer Lett. 332:3–10. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, et al: Origins of tumor-associated macrohages and neutrophils. Proc Natl Acad Sci USA. 109:2491–2496. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, et al: CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med. 19:429–436. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Ramos P, Casu C, Gardenghi S, Breda L, Crielaard BJ, Guy E, Marongiu MF, Gupta R, Levine RL, Abdel-Wahab O, et al: Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nat Med. 19:437–445. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Liu M, Jin X, He X, Pan L, Zhang X and Zhao Y: Macrophages support splenic erythropoiesis in 4T1 tumor-bearing mice. PLoS One. 10:e01219212015. View Article : Google Scholar : PubMed/NCBI

34 

Eklund CM: Proinflammatory cytokines in CRP baseline regulation. Adv Clin Chem. 48:111–136. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation and cancer. Cell. 140:883–899. 2000. View Article : Google Scholar

36 

Liu YB, Ying J, Kuang SJ, Jin HS, Yin Z, Chang L, Yang H, Ou YL, Zheng JH, Zhang WD, et al: Elevated preoperative serum Hs-CRP level as a prognostic factor in patients who underwent resection for hepatocellular carcinoma. Medicine (Baltimore). 94:e22092015. View Article : Google Scholar : PubMed/NCBI

37 

Chan SL, Chan AW, Chan AK, Jian P, Mo F, Chan CM, Mok K, Liu C, Chong CC, Chan AT, et al: Systematic evaluation of circulating inflammatory markers forhepatocellular carcinoma. Liver Int. 37:280–289. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Kim JM, Kwon CH, Joh JW, Ko JS, Park JB, Lee JH, Kim SJ, Paik SW and Park CK: C-reactive protein may be a prognostic factor in hepatocellular carcinoma with malignant portal vein invasion. World J Surg Oncol. 11:922013. View Article : Google Scholar : PubMed/NCBI

39 

Zhang Q, Shang L, Zang Y, Chen X, Zhang L, Wang Y, Wang L, Liu Y, Mao S and Shen Z: α-Fetoprotein is a potential survival predictor in hepatocellular carcinoma patients with hepatitis B selected for liver transplantation. Eur J Gastroenterol Hepatol. 26:544–552. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Liao W, Zhang J, Zhu Q, Qin L, Yao W, Lei B, Shi W, Yuan S, Tahir SA, Jin J and He S: Preoperative neutrophil-to-lymphocyte ratio as a new prognostic marker in hepatocellular carcinoma after curative resection. Transl Oncol. 7:248–255. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Choi Y, Kim JW, Cha H, Han KH and Seong J: Overall response of both intrahepatic tumor and portal vein tumor thrombosis is a good prognostic factor for hepatocellular carcinoma patients receiving concurrent chemoradiotherapy. J Radiat Res. 55:113–120. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Huang X, Wei W, Ya N, Zeng J, Zeng Y, Ma C, Chi M, Wu Y, Li Y, Huang Y, et al: A mathematical model to predict short-term recurrence and metastasis of primary hepatocellular carcinoma larger than 10 cm in diameter. Hepatogastroenterology. 60:225–230. 2013.PubMed/NCBI

43 

Xiang ZL, Zeng ZC, Fan J, Wu WZ, He J, Zeng HY and Tang ZY: A clinicopathological model to predict bone metastasis in hepatocellular carcinoma. J Cancer Res Clin Oncol. 137:1791–1797. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li M, Zhao Y, Liu X, Zhang S, Jiang Y and Yang Z: Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus. Oncol Lett 19: 3249-3257, 2020.
APA
Li, M., Zhao, Y., Liu, X., Zhang, S., Jiang, Y., & Yang, Z. (2020). Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus. Oncology Letters, 19, 3249-3257. https://doi.org/10.3892/ol.2020.11423
MLA
Li, M., Zhao, Y., Liu, X., Zhang, S., Jiang, Y., Yang, Z."Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus". Oncology Letters 19.4 (2020): 3249-3257.
Chicago
Li, M., Zhao, Y., Liu, X., Zhang, S., Jiang, Y., Yang, Z."Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus". Oncology Letters 19, no. 4 (2020): 3249-3257. https://doi.org/10.3892/ol.2020.11423
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Zhao Y, Liu X, Zhang S, Jiang Y and Yang Z: Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus. Oncol Lett 19: 3249-3257, 2020.
APA
Li, M., Zhao, Y., Liu, X., Zhang, S., Jiang, Y., & Yang, Z. (2020). Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus. Oncology Letters, 19, 3249-3257. https://doi.org/10.3892/ol.2020.11423
MLA
Li, M., Zhao, Y., Liu, X., Zhang, S., Jiang, Y., Yang, Z."Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus". Oncology Letters 19.4 (2020): 3249-3257.
Chicago
Li, M., Zhao, Y., Liu, X., Zhang, S., Jiang, Y., Yang, Z."Early risk warning system for distant metastasis of hepatitis B virus‑associated hepatocellular carcinoma with portal vein tumor thrombus". Oncology Letters 19, no. 4 (2020): 3249-3257. https://doi.org/10.3892/ol.2020.11423
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