Open Access

The roles of curcumin in regulating the tumor immunosuppressive microenvironment (Review)

  • Authors:
    • Yizhi Wang
    • Jun Lu
    • Bolun Jiang
    • Junchao Guo
  • View Affiliations

  • Published online on: March 3, 2020     https://doi.org/10.3892/ol.2020.11437
  • Pages: 3059-3070
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is a harmful threat to human health. In addition to surgery, a variety of anticancer drugs are increasingly used in cancer therapy; however, despite the developments in multimodality treatment, the morbidity and mortality of patients with cancer patients are on the increase. The tumor‑specific immunosuppressive microenvironment serves an important function in tumor tolerance and escape from immune surveillance leading to tumor progression. Therefore, identifying new drugs or foods that can enhance the tumor immune response is critical to develop improved cancer prevention methods and treatment. Curcumin, a polyphenolic compound extracted from ginger, has been shown to effectively inhibit tumor growth, proliferation, invasion, metastasis and angiogenesis in a variety of tumors. Recent studies have also indicated that curcumin can modulate the tumor immune response and remodel the tumor immunosuppressive microenvironment, indicating its potential in the immunotherapy of cancer. In this review, a brief introduction to the effects of curcumin on the tumor immune response and tumor immune microenvironment is provided and recent clinical trials investigating the potential of curcumin in cancer therapy are discussed.
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April-2020
Volume 19 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang Y, Lu J, Jiang B and Guo J: The roles of curcumin in regulating the tumor immunosuppressive microenvironment (Review). Oncol Lett 19: 3059-3070, 2020
APA
Wang, Y., Lu, J., Jiang, B., & Guo, J. (2020). The roles of curcumin in regulating the tumor immunosuppressive microenvironment (Review). Oncology Letters, 19, 3059-3070. https://doi.org/10.3892/ol.2020.11437
MLA
Wang, Y., Lu, J., Jiang, B., Guo, J."The roles of curcumin in regulating the tumor immunosuppressive microenvironment (Review)". Oncology Letters 19.4 (2020): 3059-3070.
Chicago
Wang, Y., Lu, J., Jiang, B., Guo, J."The roles of curcumin in regulating the tumor immunosuppressive microenvironment (Review)". Oncology Letters 19, no. 4 (2020): 3059-3070. https://doi.org/10.3892/ol.2020.11437