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Review Open Access

Neuroendocrine tumors of the gallbladder (Review)

  • Authors:
    • Chunyuan Niu
    • Shupeng Wang
    • Qingchun Guan
    • Xuekang Ren
    • Bai Ji
    • Yahui Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
    Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3381-3388
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    Published online on: March 12, 2020
       https://doi.org/10.3892/ol.2020.11461
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Abstract

A gallbladder neuroendocrine neoplasm (GB-NEN) is a unique heterogeneous neoplasm, originating from neuroendocrine cells and able to secrete peptides as its neurotransmitter. Among all the neuroendocrine tumors (NETs), the GB‑NEN prevalence is 0.5%, which accounts for ~2.1% of all gallbladder tumors. The current study aimed to present an up‑to‑date review of the clinical features, diagnosis and treatment of NETs of the gallbladder. A systematic literature search was performed in order to identify all relevant studies published. Thus far, the etiology and pathogenesis of GB‑NEN remains unclear. Moreover, an ambiguous clinical manifestation exists as observed during laboratory examinations. As GB‑NEN is a rare gallbladder lesion and is seldom seen in clinical practice, there is a limited availability of review reports, and it is therefore often considered only as a case study. It is difficult to distinguish GB‑NEN from other gallbladder diseases using imaging diagnostic techniques. Although chemotherapy treatment provides prolonged progression‑free survival, surgery is considered the best option. Thus, to overcome the inherent risks or shortfalls of traditional surgery; early detection, diagnosis and treatment of GB‑NEN are required to improve patient longevity.
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1 

Modlin IM, Lye KD and Kidd M: A 5-decade analysis of 13715 carcinoid tumors. Cancer. 97:934–959. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Naito S, Naito M, Yamamoto N, Kume T, Hosino S, Kinjyo Y, Naito Y, Naito H and Hasegawa S: Polypoid gallbladder neuroendocrine tumor diagnosed as benign polyp before surgery: A case report. Mol Clin Oncol. 12:225–229. 2020.PubMed/NCBI

3 

Dogra VS and Poblete J: Metaatatic carcinoid tumor in the liver. J Clin Ultrasound. 21:639–641. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Gustafsson BI, Kidd M and Modlin IM: Neuroendocrine tumors of the diffuse neuroendocrine system. Curr Opin Oncol. 20:1–12. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Eltawil KM, Gustafsson BI, Kidd M and Modlin IM: Neuroendocrine tumors of the gallbladder: An evaluation and reassessment of management strategy. J Clin Gastroenterol. 44:687–695. 2010.PubMed/NCBI

6 

Rothenstein J, Cleary SP, Pond GR, Dale D, Gallinger S, Moore MJ, Brierley J and Siu LL: Neuroendocrine tumors of the gastrointestinal tract: A decade of experience at the princess margaret hospital. Am J Clin Oncol. 31:64–70. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Oberg K: Diagnostic work-up of gastroenteropancreatic neuroendocrine tumors. Clinics (Sao Paulo). 67 (Suppl 1):S109–S112. 2012. View Article : Google Scholar

8 

Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A and Evans DB: One hundred years after ‘carcinoid’: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 26:3063–3072. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Kim J, Lee WJ, Lee SH, Lee KB, Ryu JK, Kim YT, Kim SW, Yoon YB, Hwang JH, Han HS, et al: Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours. Dig Liver Dis. 43:965–970. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Lee JM, Hwang S, Lee SG, Lee YJ, Park KM, Kim KH, Ahn CS, Kim MH, Lee SK and Kim MW: Neuroendocrine tumors of the gallbladder: Twelve cases in a single institution. Hepatogastroenterology. 57:1064–1068. 2010.PubMed/NCBI

11 

Chiorean L, Bartos A, Pelau D, Iancu D, Ciuleanu T, Buiga R, Oancea I, Mangrau A, Iancu C and Badea R: Neuroendocrine tumor of gallbladder with liver and retroperitoneal metastases and a good response to the chemotherapeutical treatment. J Med Ultrason (2001). 42:271–276. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Adachi T, Haraguchi M, Irie J, Yoshimoto T, Uehara R, Ito S, Tokai H, Noda K, Tada N, Hirabaru M, et al: Gallbladder small cell carcinoma: A case report and literature review. Surg Case Rep. 2:712016. View Article : Google Scholar : PubMed/NCBI

13 

Yun SP, Shin N and Seo HI: Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. World J Gastroenterol. 21:269–275. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Duffy A, Capanu M, Abou-Alfa GK, Huitzil D, Jarnagin W, Fong Y, D'Angelica M, Dematteo RP, Blumgart LH and O'Reilly EM: Gallbladder cancer (GBC): 10-year experience at memorial sloan-kettering cancer center (MSKCC). J Surg Oncol. 98:485–489. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Komori Y, Yada K, Ohta M, Uchida H, Iwashita Y, Fukuzawa K, Kashima K, Yokoyama S, Inomata M and Kitano S: Mammalian target of rapamycin signaling activation patterns in pancreatic neuroendocrine tumors. J Hepatobiliary Pancreat Sci. 21:288–295. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Missiaglia E, Dalai I, Barbi S, Beghelli S, Falconi M, della Peruta M, Piemonti L, Capurso G, Di Florio A, delle Fave G, et al: Pancreatic endocrine tumors: Expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol. 28:245–255. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Scoazec JY: Angiogenesis in neuroendocrine tumors: Therapeutic applications. Neuroendocrinology. 97:45–56. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Luttges J: What's new? The 2010 WHO classification for tumours of the pancreas. Pathologe. 32 (Suppl 2):S332–S336. 2011.(In German).

19 

Bosman FT, Camelr F, Hruban RH and Theise ND: World Health Organization classification of tumours of the digestive system [M]. IARC Press; Lyon: pp. 195–334. 2010

20 

Ayabe RI, Wach M, Ruff S, Martin S, Diggs L, Wiemken T, Hinyard L, Davis JL, Luu C and Hernandez JM: Primary gallbladder neuroendocrine tumors: Insights into a rare histology using a large national database. Ann Surg Oncol. 26:3577–3585. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Bae JS, Kim SH, Yoo J, Kim H and Han JK: Differential and prognostic MRI features of gallbladder neuroendocrine tumors and adenocarcinomas. Eur Radiol. Feb 5–2020.(Epub ahead of print). doi: 10.1007/s00330-019-06588-9. View Article : Google Scholar

22 

Moskal TL, Zhang PJ and Nava HR: Small cell carcinoma of the gallbladder. J Surg Oncol. 70:54–59. 1999. View Article : Google Scholar

23 

Fujimoto G, Yamada S, Kusanagi H and Uegami W: Rapidly growing neuroendocrine carcinoma of the gallbladder: A case report. Radiol Case Rep. 15:259–265. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Chakrabarti D, Qayoom S, Ghosh A and Gupta R: Neuroendocrine carcinoma of the gall bladder in a young lady presenting with upper abdominal heaviness: A common complaint and a rare diagnosis. BMJ Case Rep. 12:e2296842019. View Article : Google Scholar : PubMed/NCBI

25 

Skalický A, Vištejnová L, Dubová M, Malkus T, Skalický T and Troup O: Mixed neuroendocrine-non-neuroendocrine carcinoma of gallbladder: Case report. World J Surg Oncol. 17:552019. View Article : Google Scholar : PubMed/NCBI

26 

Shimono C, Suwa K, Sato M, Shirai S, Yamada K, Nakamura Y and Makuuchi M: Large cell neuroendocrine carcinoma of the gallbladder: Long survival achieved by multimodal treatment. Int J Clin Oncol. 14:351–355. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Neyaz A, Husain N, Gupta S, Kumari S, Arora A, Awasthi NP, Malhotra KP and Misra S: Investigation of targetable predictive and prognostic markers in gallbladder carcinoma. J Gastrointest Oncol. 9:111–125. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Adachi T, Haraguchi M, Irie J, Yoshimoto T, Uehara R, Ito S, Tokai H, Noda K, Tada N, Hirabaru M, et al: Gallbladder small cell carcinoma: A case report and literature review. Surg Case Rep. 2:712016. View Article : Google Scholar : PubMed/NCBI

29 

Nishigami T, Yamada M, Nakasho K, Yamamura M, Satomi M, Uematsu K, Ri G, Mizuta T and Fukumoto H: Cacinoid tumor of the gall bladder. Intern Med. 35:953–956. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Handra-Luca A: Gallbladder neuroendocrine carcinoma: Metastasis or synchronous tumor? Minerva Chir. 73:619–620. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Liu W, Chen W, He X, Qu Q, Hong T and Li B: Cholecystectomy with gallbladder bed cautery might be sufficient for T1bN0M0 neuroendocrine carcinoma of gallbladders: Cases report and literature review. Medicine (Baltimore). 96:e87782017. View Article : Google Scholar : PubMed/NCBI

32 

Hussain I, Sarvepalli D, Zafar H, Jehanzeb S and Ullah W: Neuroendocrine tumor: A rare, aggressive tumor of the gallbladder. Cureus. 11:e55712019.PubMed/NCBI

33 

Liu W, Chen W, Chen J, Hong T, Li B, Qu Q and He X: Neuroendocrine carcinoma of gallbladder: A case series and literature review. Eur J Med Res. 24:82019. View Article : Google Scholar : PubMed/NCBI

34 

Soga J: Carcinoids and their variant endocrinomas. An analysis of 11,842 reported cases. J Exp Clin Cancer Res. 22:517–530. 2003.PubMed/NCBI

35 

Yadav R, Jain D, Mathur SR and Iyer VK: Cytomorphology of neuroendocrine tumours of the gallbladder. Cytopathology. 27:97–102. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Peracchi M, Gebbia C, Basilisco G, Quatrini M, Tarantino C, Vescarelli C, Massironi S and Conte D: Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis, enterochromaffin-like cell lesions and gastric carcinoids. Eur J Endocrinol. 152:443–448. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Monier A, Saloum N, Szmigielski W, Alrashid A and Napaki SM: Neuroendocrine tumor of the gallbladder. Pol J Radiol. 80:228–231. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Leem G, Chung MJ, Park JY, Bang S, Song SY, Chung JB and Park SW: Clinical value of contrast-enhanced harmonic endoscopic ultrasonography in the differential diagnosis of pancreatic and gallbladder masses. Clin Endosc. 51:80–88. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Sugimoto M, Takagi T, Suzuki R, Konno N, Asama H, Watanabe K, Nakamura J, Kikuchi H, Waragai Y, Takasumi M, et al: Contrast-enhanced harmonic endoscopic ultrasonography in gallbladder cancer and pancreatic cancer. Fukushima J Med Sci. 63:39–45. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Reimão S, Francioni E, Bories E, Caillol F, Pesenti C and Giovannini M: Endoscopic ultrasonography-guided bi-lateral biliary drainage: A case series study. Endosc Ultrasound. 3 (Suppl 1):S182014.PubMed/NCBI

41 

Samad A, Kaplan A, Arain M, Attam R, Jessurun J, Manivel JC and Pambuccian SE: Endoscopic ultrasound-guided fine-needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: Report of a case. Diagn Cytopathol. 41:1091–1095. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Abutaka A, El-Matbouly M, Helmy I, Elmoghazy W, Sulieman I, Ben Gashir M, Soofi M, Khalaf H and Elaffandi A: Repeat liver resection for pure large cell neuroendocrine carcinoma of the gallbladder: A favorable outcome. World J Surg Oncol. 17:1262019. View Article : Google Scholar : PubMed/NCBI

43 

Iype S, Mirza TA, Pmpper DJ, Bhattacharya S, Feakins RM and Kocher HM: Neuroendocrine tumours of the gaHbladder: Three cases and a review of the literature. Postgrad Med J. 85:213–218. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Hirose Y, Sakata J, Endo K, Takahashi M, Saito R, Imano H, Kido T, Yoshino K, Sasaki T and Wakai T: A 0.8-cm clear cell neuroendocrine tumor G1 of the gallbladder with lymph node metastasis: A case report. World J Surg Oncol. 16:1502018. View Article : Google Scholar : PubMed/NCBI

45 

You YH, Choi DW, Heo JS, Han IW, Choi SH, Jang KT and Han S: Can surgical treatment be justified for neuroendocrine carcinoma of the gallbladder? Medicine (Baltimore). 98:e148862019. View Article : Google Scholar : PubMed/NCBI

46 

Sun YW and Liu DJ: Neuroendocrine carcinoma of the gallbladder. Chin J Pract Surg. 31:265–267. 2011.(In Chinese).

47 

Garg PK, Pandey D and Sharma J: The surgical management of gallbladder cancer. Expert Rev Gastroenterol Hepatol. 9:155–166. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D and Schizas D: Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A systematic review of outcomes following surgical management. In Vivo. 33:1721–1726. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Elm'hadi C, Zerrik M, Errihani H and Ichou M: A long survival woman with primary small-cell carcinoma of the gallbladder: Role of chemotherapy maintenance. Cureus. 9:e13682017.PubMed/NCBI

50 

Shoushtari AN, Bluth MJ, Goldman DA, Bitas C, Lefkowitz RA, Postow MA, Munhoz RR, Buchar G, Hester RH, Romero JA, et al: Clinical features and response to systemic therapy in a historical cohort of advanced or unresectable mucosal melanoma. Melanoma Res. 27:57–64. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Tani S, Yamagishi S, Fukunaga K, Morita M, Sonoda T, Murao S, Ikuta S, Kakuno A and Yamanaka N: A case of disease-free, long survival in a patient with mixed adenoneuroendocrine carcinoma of the gallbladder treated with induction CDDP/CPT-11 chemotherapy and resection. Gan To Kagaku Ryoho. 42:113–117. 2015.(In Japanese). PubMed/NCBI

52 

Smith JL and Davis BR: Neuroendocrine tumor of the gallbladder treated with neoadjuvant chemotherapy and surgery. Am Surg. 80:318–320. 2014.PubMed/NCBI

53 

Elahi F, Ahmadzadeh A, Yadonahzadeh M, Hassanpour K and Babaei M: Neuroendocrine tumor of the gallbladder. Arch Iran Med. 16:123–125. 2013.PubMed/NCBI

54 

Okuyama Y, Fukui A, Enoki Y, Morishita H, Yoshida N and Fujimoto S: A large cell neuroendocrine carcinoma of the gall bladder: Diagnosis with 18FDGPET/CT-guided biliary cytology and treatment with combined chemotherapy achieved a long-term stable condition. Jpn J Clin Oncol. 43:571–574. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Inoue D, Ozaka M, Muramatsu Y, Yamada I, Matsuyama M, Kanda H and Ishii H: Neuroendocrine gallbladder cancer treated with cisplatin plus irinotecan-A case report. Gan To Kagaku Ryoho. 41:765–767. 2014.(In Japanese). PubMed/NCBI

56 

Barakat MT, Meeran K and Bloom SR: Neuroendocrine tumours. Endocr Relat Cancer. 11:1–18. 2004. View Article : Google Scholar : PubMed/NCBI

57 

Pavel ME, Hassler G, Baum U, Hahn EG, Lohmann T and Schuppan D: Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in neuroendocrine carcinomas. Clin Endocrinol (Oxf). 62:434–443. 2005. View Article : Google Scholar : PubMed/NCBI

58 

Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C, Valle J, Metrakos P, Smith D, Vinik A, et al: Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. 364:501–513. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, de Vries EG, et al: Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 364:514–523. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Caplin ME, Pavel M, Cwikla JB, Phan AT, Raderer M, Sedláčková E, Cadiot G, Wolin EM, Capdevila J, Wall L, et al: Lanreotide in metastatic enteropancreatic neuroendocrine tumors. N Engl J Med. 371:224–233. 2014. View Article : Google Scholar : PubMed/NCBI

61 

Igaz P: Efficacy of somatostatin analogues in the treatment of neuroendocrine tumours based on the results of recent clinical trials. Orv Hetil. 155:1908–1912. 2014.(In Hungarian). View Article : Google Scholar : PubMed/NCBI

62 

Oberg K, Akerstrom G, Rindi G and Jelic S; ESMO Guidelines Working Group, : Neuroendocrine gastroenteropancreatic tumours: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 21 (Suppl 5):v223–v227. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Lin PC, Lai YC, Lai JI, Hsu SY and Wang WS: Successful treatment of gallbladder neuroendocrine carcinoma with combined chemo-radiotherapy: A case report and literature review. Int J Clin Pharmacol Ther. 49:403–408. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Kwekkeboom DJ, de Herder WW, Kam BL, van Eijck CH, van Essen M, Kooij PP, Feelders RA, van Aken MO and Krenning EP: Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0, Tyr3] octreotate: Toxicity, efficacy, and survival. J Clin Oncol. 26:2124–2130. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Roversi R, Ricci S, Rossi G, Roversi M and Cavallo G: Locoregional therapy with hypoxic liver perfusion in malignant neoplasms of the gallbladder. Preliminary experience. Radiol Med. 94:220–225. 1997.(In Italian). PubMed/NCBI

66 

Garin E, Rolland Y, Boucher E, Ardisson V, Laffont S, Boudjema K, Bourguet P and Raoul JL: First experience of hepatic radioembolization using microspheres labelled with yttrium-90 (TheraSphere): Practical aspects concerning its implementation. Eur J Nucl Med Mol Imaging. 37:453–461. 2010. View Article : Google Scholar : PubMed/NCBI

67 

Kamei K, Shindoh J, Kiya Y, Matsumoto I, Hashimoto M and Takeyama Y: Conversion surgery after extensive chemotherapy for stage IV mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: Clinical implications from the patterns of response and recurrence. Clin J Gastroenterol. Oct 15–2019.(Epub ahead of print). doi: 10.1007/s12328-019-01053-y. View Article : Google Scholar : PubMed/NCBI

68 

Salimi Z and Sharafuddin M: Ultrasound appearance of primary carcinoid tumor of the gallbladder associated with carcinoid syndrome. J Clin Ultrasound. 23:435–437. 1995. View Article : Google Scholar : PubMed/NCBI

69 

Soga J: Primary endocrinomas (carcinoids and variant neoplasms) of the gallbladder: A statistical evaluation of 138 reported cases. J Exp Clin Cancer Res. 22:5–15. 2003.PubMed/NCBI

70 

Pantongrag-Brown L, Buetow PC, Carr NJ, Lichtenstein JE and Buck JL: Calcification and fibrosis in mesenteric carcinoid tumor: CT findings and pathologic correlation. AJR Am J Roentgenol. 164:387–391. 1995. View Article : Google Scholar : PubMed/NCBI

71 

Shapera E and Bitting C: Survival: A rare outcome in large cell neuroendocrine carcinoma of the gallbladder. Acta Gastroenterol Belg. 82:433–436. 2019.PubMed/NCBI

72 

Deshmukh SD, Gulati HK, Gaopande V, Purandare S and Anand M: Incidental cystic endocrine tumor of the pancreas: A case report with immunohistochemical study. J Cancer Res Ther. 8:289–291. 2012. View Article : Google Scholar : PubMed/NCBI

73 

Iwasa S, Morizane C, Okusaka T, Ueno H, Ikeda M, Kondo S, Tanaka T, Nakachi K, Mitsunaga S, Kojima Y, et al: Cisplatin and etoposide as first-line chemotherapy for poorly differentiated neuroendocrine carcinoma of the hepatobiliary tract and pancreas. Jpn J Clin Oncol. 40:313–318. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Niu C, Wang S, Guan Q, Ren X, Ji B and Liu Y: Neuroendocrine tumors of the gallbladder (Review). Oncol Lett 19: 3381-3388, 2020.
APA
Niu, C., Wang, S., Guan, Q., Ren, X., Ji, B., & Liu, Y. (2020). Neuroendocrine tumors of the gallbladder (Review). Oncology Letters, 19, 3381-3388. https://doi.org/10.3892/ol.2020.11461
MLA
Niu, C., Wang, S., Guan, Q., Ren, X., Ji, B., Liu, Y."Neuroendocrine tumors of the gallbladder (Review)". Oncology Letters 19.5 (2020): 3381-3388.
Chicago
Niu, C., Wang, S., Guan, Q., Ren, X., Ji, B., Liu, Y."Neuroendocrine tumors of the gallbladder (Review)". Oncology Letters 19, no. 5 (2020): 3381-3388. https://doi.org/10.3892/ol.2020.11461
Copy and paste a formatted citation
x
Spandidos Publications style
Niu C, Wang S, Guan Q, Ren X, Ji B and Liu Y: Neuroendocrine tumors of the gallbladder (Review). Oncol Lett 19: 3381-3388, 2020.
APA
Niu, C., Wang, S., Guan, Q., Ren, X., Ji, B., & Liu, Y. (2020). Neuroendocrine tumors of the gallbladder (Review). Oncology Letters, 19, 3381-3388. https://doi.org/10.3892/ol.2020.11461
MLA
Niu, C., Wang, S., Guan, Q., Ren, X., Ji, B., Liu, Y."Neuroendocrine tumors of the gallbladder (Review)". Oncology Letters 19.5 (2020): 3381-3388.
Chicago
Niu, C., Wang, S., Guan, Q., Ren, X., Ji, B., Liu, Y."Neuroendocrine tumors of the gallbladder (Review)". Oncology Letters 19, no. 5 (2020): 3381-3388. https://doi.org/10.3892/ol.2020.11461
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