Open Access

Prognostic value of quantitative FDG‑PET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy

  • Authors:
    • Tomoyuki Oyama
    • Yoichiro Hosokawa
    • Kazuki Abe
    • Kazuki Hasegawa
    • Roman Fukui
    • Masahiko Aoki
    • Wataru Kobayashi
  • View Affiliations

  • Published online on: March 27, 2020     https://doi.org/10.3892/ol.2020.11488
  • Pages: 3775-3780
  • Copyright: © Oyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The current study aimed to evaluate the relationship between 18F‑fluorodeoxyglucose positron emission tomography with computed tomography (FDG‑PET‑CT) standardized uptake value (SUV) [pre‑treatment SUV (pre‑SUV) and post‑treatment SUV (post‑SUV)] and treatment results in patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy (SSIACRT). A total of 37 patients with advanced oral cancer were treated with SSIACRT. The treatment consisted of superselective intra‑arterial chemotherapy (docetaxel (DOC) 40 mg/mm2 and nedaplatin (CDGP) 80 mg/mm2) and concurrent radiotherapy (60‑70 Gy) for a period of seven weeks. Pre‑SUV and post‑SUV of the primary tumor were measured. Overall survival (OS) and local control (LC) rates were selected as endpoints to evaluate prognosis. The median follow‑up was 40 months (range 6‑112 months). The 5‑year OS and LC rates were 64.5 and 85.5%, respectively, and SSIACRT achieved high LC rate even in advanced oral cancers. In the log‑rank test, post‑SUV was a significant prognostic factor for OS and LC rates. The results of the current study demonstrated that SSIACRT is a reliable treatment with respect to survival in advanced oral cancer and post‑SUV was a significant prognostic factor for OS and LC rates.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Oyama T, Hosokawa Y, Abe K, Hasegawa K, Fukui R, Aoki M and Kobayashi W: Prognostic value of quantitative FDG‑PET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy. Oncol Lett 19: 3775-3780, 2020
APA
Oyama, T., Hosokawa, Y., Abe, K., Hasegawa, K., Fukui, R., Aoki, M., & Kobayashi, W. (2020). Prognostic value of quantitative FDG‑PET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy. Oncology Letters, 19, 3775-3780. https://doi.org/10.3892/ol.2020.11488
MLA
Oyama, T., Hosokawa, Y., Abe, K., Hasegawa, K., Fukui, R., Aoki, M., Kobayashi, W."Prognostic value of quantitative FDG‑PET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy". Oncology Letters 19.6 (2020): 3775-3780.
Chicago
Oyama, T., Hosokawa, Y., Abe, K., Hasegawa, K., Fukui, R., Aoki, M., Kobayashi, W."Prognostic value of quantitative FDG‑PET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy". Oncology Letters 19, no. 6 (2020): 3775-3780. https://doi.org/10.3892/ol.2020.11488