High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma

Shen,An; Ma,Jinping; Hu,Xiaolin; Cui,Xinjiang

doi:10.3892/ol.2020.11490

High expression of lncRNA-SNHG7 is associated with poor prognosis in hepatocellular carcinoma

Authors:
- An Shen
- Jinping Ma
- Xiaolin Hu
- Xinjiang Cui
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Affiliations: Department of Hepatological Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261041, P.R. China, Department of Obstetrics, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261041, P.R. China, Department of General Surgery, Shouguang People's Hospital, Shouguang, Shandong 262700, P.R. China, Department of Interventional Oncology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261041, P.R. China
Published online on: March 27, 2020 https://doi.org/10.3892/ol.2020.11490
Pages: 3959-3963
Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportional models were used to study the impact on clinical outcome. Expression of lncRNA-SNHG7 was much higher in cancer tissues than that in para-cancer tissues. The lncRNA-SNHG7 expression was correlated with tumor number, lymph node metastasis and clinical stage (P<0.05). In addition, HCC patients with higher lncRNA-SNHG7 expression had significantly poorer progression-free survival time and overall survival time (P<0.001). Both univariate analysis and multivariate analysis indicated that high expression of lncRNA-SNHG7 was an independent predictor of poor prognosis in HCC. LncRNA-SNHG7 might contribute to the development of HCC and serve as a clinical biomarker and a therapeutic target for HCC patients.

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