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Advantages of gross total resection in patients with astrocytoma: A population‑based study

  • Authors:
    • Hua Mao
    • Xianguo Li
    • Weipu Mao
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Jingzhou Central Hospital, The Second Clinical Medical College of Yangtze University, Jingzhou, Hubei 434020, P.R. China, Department of General Practice, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
    Copyright: © Mao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3761-3774
    |
    Published online on: April 6, 2020
       https://doi.org/10.3892/ol.2020.11514
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Abstract

The present study aimed to investigate the association between surgical methods and survival outcomes in patients with astrocytoma. Patients diagnosed with astrocytoma between January 2004 and December 2015 were identified using the Surveillance, Epidemiology and End Results database. Kaplan‑Meier curves and Cox regression were used to analyze the effects of surgical methods on overall survival (OS) and cancer‑specific survival (CSS). Among 42,224 eligible patients with astrocytoma, 11,427 (27.1%) patients did not receive surgery, 7,661 (18.1%) received excisional biopsy (EB), 5,520 (13.1%) received a subtotal resection (STR), 6,037 (14.3%) received a gross resection (GR), 5,314 (12.6%) received a partial resection (PR) and 6,265 (14.8%) received a gross total resection (GTR). Patients who underwent GR had the longest survival time (17.00 months). However, over time, the proportion of patients who underwent STR or GR increased, whereas the proportion of patients who did not undergo surgery, PR or GTR decreased. Furthermore, surgical method was an independent prognostic factor for OS and CSS for the patients with astrocytoma. Multivariate Cox regression showed that GTR was associated with the more favorable OS [hazard ratio (HR), 0.80; 95% confidence interval (CI), 0.77‑0.83; P<0.001] and CSS (HR, 0.80; 95% CI, 0.77‑0.83; P<0.001) times compared with EB. Moreover, similar results were observed in subgroup analyses based on summary stage and grade. In the present study, it was demonstrated that GTR was one of the effective surgical methods for improved OS and CSS time in patients with astrocytoma. However, among the American astrocytoma population, the proportion of patients who underwent GTR decreased. It is necessary to further advocate for the efficacy of GTR.
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1 

Teng YD, Abd-El-Barr M, Wang L, Hajiali H, Wu L and Zafonte RD: Spinal cord astrocytomas: Progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies. Exp Neurol. 311:135–147. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Iida T, Tomogane Y, Takagi T, Miyaji Y, Sakamoto D, Yoshida Y, Ishikura R, Ando K, Nakagomi N, Hirota S and Yoshimura S: Grading of astrocytomas using the PRESTO (principles of echo-shifting with a train of observations) magnetic resonance imaging sequence. Clin Neurol Neurosurg. 173:91–95. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Xie JC, Yang S, Liu XY and Zhao YX: Marital status is associated with survival of patients with astrocytoma. J Clin Neurosci. 56:79–87. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Wen PY and Kesari S: Malignant gliomas in adults. N Engl J Med. 359:492–507. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro Oncol. 21 (Suppl 5):v1–v100. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Walker DG and Kaye AH: Diagnosis and management of astrocytomas, oligodendrogliomas and mixed gliomas: A review. Australas Radiol. 45:472–482. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Donofrio CA, Gagliardi F, Callea M, da Passano CF, Terreni MR, Cavalli A, Spina A, Acerno S, Bailo M, Elbabaa SK and Mortini P: Pediatric cerebellar pilocytic astrocytoma presenting with spontaneous intratumoral hemorrhage. Neurosurg Rev. 2018.(Epub ahead of print). PubMed/NCBI

8 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Weidmann MJ: Neurosurgery. Med J Aust. 161:392–394. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Tavares CB, Gomes-Braga FDCS, Sousa EB, Borges US, Escórcio-Dourado CS, Silva-Sampaio JPD and Silva BBD: Evaluation of estrogen receptor expression in low-grade and high-grade astrocytomas. Rev Assoc Med Bras (1992). 64:1129–1133. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Guastella AR, Michelhaugh SK, Klinger NV, Fadel HA, Kiousis S, Ali-Fehmi R, Kupsky WJ, Juhász C and Mittal S: Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. J Neurooncol. 139:239–249. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Delgado-Lopez PD, Corrales-Garcia EM, Martino J, Lastra-Aras E and Duenas-Polo MT: Diffuse low-grade glioma: A review on the new molecular classification, natural history and current management strategies. Clin Transl Oncol. 19:931–944. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Patel S, DiBiase S, Meisenberg B, Flannery T, Patel A, Dhople A, Cheston S and Amin P: Phase I clinical trial assessing temozolomide and tamoxifen with concomitant radiotherapy for treatment of high-grade glioma. Int J Radiat Oncol Biol Phys. 82:739–742. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Ghotme KA, Barreto GE, Echeverria V, Gonzalez J, Bustos RH, Sanchez M, Leszek J, Yarla NS, Gomez RM, Tarasov VV, et al: Gliomas: New perspectives in diagnosis, treatment and prognosis. Curr Top Med Chem. 17:1438–1447. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Mao W, Huang X, Kong M, Fan J and Geng J: More lymph node dissection improves survival in patients with newly diagnosed lymph node-positive penile cancer. Int Urol Nephrol. 51:641–654. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Mao W, Kong M, Yu H, Wang D, Huang X, Yao X, Fan J and Geng J: Prognosis and treatment differences between initial and second primary chondrosarcoma. Oncol Lett. 18:207–218. 2019.PubMed/NCBI

17 

Alattar AA, Brandel MG, Hirshman BR, Dong X, Carroll KT, Ali MA, Carter BS and Chen CC: Oligodendroglioma resection: A surveillance, epidemiology, and end results (SEER) analysis. J Neurosurg. 128:1076–1083. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Dong X, Noorbakhsh A, Hirshman BR, Zhou T, Tang JA, Chang DC, Carter BS and Chen CC: Survival trends of grade I, II, and III astrocytoma patients and associated clinical practice patterns between 1999 and 2010: A SEER-based analysis. Neurooncol Pract. 3:29–38. 2016.PubMed/NCBI

19 

Karajannis M, Allen JC and Newcomb EW: Treatment of pediatric brain tumors. J Cell Physiol. 217:584–589. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Johnson DR, Brown PD, Galanis E and Hammack JE: Pilocytic astrocytoma survival in adults: Analysis of the surveillance, epidemiology, and end results program of the national cancer institute. J Neurooncol. 108:187–193. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Keles GE, Chang EF, Lamborn KR, Tihan T, Chang CJ, Chang SM and Berger MS: Volumetric extent of resection and residual contrast enhancement on initial surgery as predictors of outcome in adult patients with hemispheric anaplastic astrocytoma. J Neurosurg. 105:34–40. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Smith JS, Chang EF, Lamborn KR, Chang SM, Prados MD, Cha S, Tihan T, Vandenberg S, McDermott MW and Berger MS: Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol. 26:1338–1345. 2008. View Article : Google Scholar : PubMed/NCBI

23 

McGirt MJ, Chaichana KL, Attenello FJ, Weingart JD, Than K, Burger PC, Olivi A, Brem H and Quinoñes-Hinojosa A: Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. 63:700–707. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Fouladi M, Jenkins J, Burger P, Langston J, Merchant T, Heideman R, Thompson S, Sanford A, Kun L and Gajjar A: Pleomorphic xanthoastrocytoma: Favorable outcome after complete surgical resection. Neuro Oncol. 3:184–192. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, et al: A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival. J Neurosurg. 95:190–198. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Sanai N and Berger MS: Glioma extent of resection and its impact on patient outcome. Neurosurgery. 62:753–764; discussion 264–756. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Li YM, Suki D, Hess K and Sawaya R: The influence of maximum safe resection of glioblastoma on survival in 1229 patients: Can we do better than gross-total resection? J Neurosurg. 124:977–988. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Freeman CR and Suissa S: Brain stem tumors in children: Results of a survey of 62 patients treated with radiotherapy. Int J Radiat Oncol Biol Phys. 12:1823–1828. 1986. View Article : Google Scholar : PubMed/NCBI

29 

Grigsby PW, Thomas PR, Schwartz HG and Fineberg BB: Multivariate analysis of prognostic factors in pediatric and adult thalamic and brainstem tumors. Int J Radiat Oncol Biol Phys. 16:649–655. 1989. View Article : Google Scholar : PubMed/NCBI

30 

Minehan KJ, Brown PD, Scheithauer BW, Krauss WE and Wright MP: Prognosis and treatment of spinal cord astrocytoma. Int J Radiat Oncol Biol Phys. 73:727–733. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Hongo H, Takai K, Komori T and Taniguchi M: Intramedullary spinal cord ependymoma and astrocytoma: Intraoperative frozen-section diagnosis, extent of resection, and outcomes. J Neurosurg Spine. 30:133–139. 2019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Mao H, Li X and Mao W: Advantages of gross total resection in patients with astrocytoma: A population‑based study. Oncol Lett 19: 3761-3774, 2020.
APA
Mao, H., Li, X., & Mao, W. (2020). Advantages of gross total resection in patients with astrocytoma: A population‑based study. Oncology Letters, 19, 3761-3774. https://doi.org/10.3892/ol.2020.11514
MLA
Mao, H., Li, X., Mao, W."Advantages of gross total resection in patients with astrocytoma: A population‑based study". Oncology Letters 19.6 (2020): 3761-3774.
Chicago
Mao, H., Li, X., Mao, W."Advantages of gross total resection in patients with astrocytoma: A population‑based study". Oncology Letters 19, no. 6 (2020): 3761-3774. https://doi.org/10.3892/ol.2020.11514
Copy and paste a formatted citation
x
Spandidos Publications style
Mao H, Li X and Mao W: Advantages of gross total resection in patients with astrocytoma: A population‑based study. Oncol Lett 19: 3761-3774, 2020.
APA
Mao, H., Li, X., & Mao, W. (2020). Advantages of gross total resection in patients with astrocytoma: A population‑based study. Oncology Letters, 19, 3761-3774. https://doi.org/10.3892/ol.2020.11514
MLA
Mao, H., Li, X., Mao, W."Advantages of gross total resection in patients with astrocytoma: A population‑based study". Oncology Letters 19.6 (2020): 3761-3774.
Chicago
Mao, H., Li, X., Mao, W."Advantages of gross total resection in patients with astrocytoma: A population‑based study". Oncology Letters 19, no. 6 (2020): 3761-3774. https://doi.org/10.3892/ol.2020.11514
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