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Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies

  • Authors:
    • Valeska Moentenich
    • Florian Gebauer
    • Erdem Comut
    • Armin Tuchscherer
    • Christiane Bruns
    • Wolfgang Schroeder
    • Reinhard Buettner
    • Hakan Alakus
    • Heike Loeser
    • Thomas Zander
    • Alexander Quaas
  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Hematology, University of Cologne, D‑50937 Cologne, Germany, Department of Visceral Surgery, University of Cologne, D‑50937 Cologne, Germany, Institute of Pathology, Pammukale University, Denizli 20160, Turkey, Institute of Pathology, University of Cologne, D‑50937 Cologne, Germany
    Copyright: © Moentenich et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3665-3670
    |
    Published online on: April 7, 2020
       https://doi.org/10.3892/ol.2020.11520
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Abstract

The incidence of esophageal adenocarcinoma (EAC) has rapidly increased, particularly in the Western world. Despite improvements in perioperative treatments, the overall survival of patients remains low. Claudin 18.2 is a tight junction protein that is exclusively expressed in the gastric epithelia. However, following malignant transformation, gastric cancer metastases maintain this expression. Therefore, claudin 18.2 is a promising target for immunotherapy. Previous clinical trials have revealed improved anti‑tumor activity in patients treated with an anti‑claudin antibody by investigating the expression of claudin 18.2 in tumor cells. However, there is currently very limited data on the importance of claudin 18.2 expression in EAC. The present study analyzed the distribution of claudin 18.2 using immunohistochemistry in 485 patients with EAC, including their lymph node metastases. Additionally, these results were associated with clinical and molecular data. Claudin 18.2 was detected in 89/485 patients (18.4%). No correlations between expression and clinicopathological data (sex, age, pT stage, lymph node metastasis and grading) were observed. However, significantly decreased claudin 18.2 expression was observed in tumor types with upregulated human epidermal growth factor receptor 2 expression (P=0.036). Additionally, neoadjuvant treatment did not have any significant impact on claudin 18.2 expression (P=0.331). To the best of our knowledge, the present study is the largest systematic investigation of claudin 18.2 protein expression in EAC. The results obtained suggested that claudin 18.2 may serve as a promising therapeutic target in a substantial number of patients with EAC.
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1 

Global Burden of Disease Cancer Collaboration, ; Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T, Alizadeh-Navaei R, Allen C, Alsharif U, Alvis-Guzman N, Amini E, et al: Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: A systematic analysis for the global burden of disease study. JAMA Oncol. 1:1533–1568. 2018.

2 

Lepage C, Rachet B, Jooste V, Faivre J and Coleman MP: Continuing rapid increase in esophageal adenocarcinoma in England and Wales. Am J Gastroenterol. 103:2694–2649. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Edgren G, Adami HO, Weiderpass E and Nyren O: A global assessment of the oesophageal adenocarcinoma epidemic. Gut. 62:1406–1414. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Al-Batran SE, Goetze TO, Mueller DW, Vogel A, Winkler M, Lorenzen S, Novotny A, Pauligk C, Homann N, Jungbluth T, et al: The RENAISSANCE (AIO-FLOT5) trial: Effect of chemotherapy alone vs. Chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction-a phase III trial of the German AIO/CAO-V/CAOGI. BMC Cancer. 17:8932017. View Article : Google Scholar : PubMed/NCBI

5 

Pohl H, Sirovich B and Welch HG: Esophageal adenocarcinoma incidence: Are we reaching the peak? Cancer Epidemiol Biomarkers Prev. 19:1468–1470. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Barrett JC: Mechanisms of multistep carcinogenesis and carcinogen risk assessment. Environ Health Perspect. 100:9–20. 1993. View Article : Google Scholar : PubMed/NCBI

7 

Nones K, Waddell N, Wayte N, Patch AM, Bailey P, Newell F, Holmes O, Fink JL, Quinn MCJ, Tang YH, et al: Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nat Commun. 5:52242014. View Article : Google Scholar : PubMed/NCBI

8 

Li X, Galipeau PC, Paulson TG, Sanchez CA, Arnaudo J, Liu K, Sather CL, Kostadinov RL, Odze RD, Kuhner MK, et al: Temporal and spatial evolution of somatic chromosomal alterations: A case-cohort study of barrett's esophagus. Cancer Prev Res (Phila). 7:114–127. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (Hrsg). Berlin: Krebs in Deutschland für. 2013/2014. 2017

10 

Tustumi F, Kimura CM, Takeda FR, Uema RH, Salum RA, Ribeiro-Junior U and Cecconello I: Prognostic factors and survival analysis in esophageal carcinoma. Arq Bras Cir Dig. 29:138–141. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Tsukita S, Furuse M and Itoh M: Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2:285–293. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Tsukita S, Yamazaki Y, Katsuno T, Tamura A and Tsukita S: Tight junction-based epithelial microenvironment and cell proliferation. Oncogene. 27:6930–6938. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Van Itallie CM and Anderson JM: Claudins and epithelial paracellular transport. Annu Rev Physiol. 68:403–429. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Mineta K, Yamamoto Y, Yamazaki Y, Tanaka H, Tada Y, Saito K, Tamura A, Igarashi M, Endo T, Takeuchi K and Tsukita S: Predicted expansion of the claudin multigene family. FEBS Lett. 585:606–612. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Sahin U, Koslowski M, Dhaene K, Usener D, Brandenburg G, Seitz G, Huber C and Türeci O: Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. Clin Cancer Res. 14:7624–7634. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Singh P, Toom S and Huang Y: Anti-Claudin 18.2 antibody as new targeted therapy for advanced gastric cancer. J Hematol Oncol. 10:1052017. View Article : Google Scholar : PubMed/NCBI

17 

Woll S, Schlitter AM, Dhaene K, Roller M, Esposito I, Sahin U and Türeci Ö: Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms. Int J Cancer. 134:731–739. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Sahin U, Schuler M, Richly H, Bauer S, Krilova A, Dechow T, Jerling M, Utsch M, Rohde C, Dhaene K, et al: A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer. Eur J Cancer. 100:17–26. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Al-Batran S, Al-Batran SE, Schuler MH, et al: FAST: An international, multicenter, randomized, phase II trial of epirubicin, oxaliplatin, and capecitabine (EOX) with or without IMAB362, a first-in-class anti-CLDN18.2 antibody, as first-line therapy in patients with advanced CLDN18.2+ gastric and gastroesophageal junction (GEJ) adenocarcinoma. J Clin Oncol. 34 (no. 18-Suppl):2016. View Article : Google Scholar : PubMed/NCBI

20 

Trarbach T, Schuler M, Zvirbule Z, Lordick F, Krilova A, Helbig U, Schulze-Bergkamen H, Thuss-Patience PC, Wichert G, Schmiegel W, et al: 636P-Efficacy and safety of multiple doses of IMAB362 in patients with advanced gastro-esophageal cancer: Results of a phase II study. Ann Oncol. 25 (Suppl 4):iv210–iv253. 2014. View Article : Google Scholar

21 

Sahin U, Al-Batran SE, Hozaeel W, et al: IMAB362 plus zoledronic acid (ZA) and interleukin-2 (IL-2) in patients (pts) with advanced gastroesophageal cancer (GEC): Clinical activity and safety data from the PILOT phase I trial. J Clin Oncol. 33 (no. 15_Suppl):2015. View Article : Google Scholar

22 

Holscher AH, Schneider PM, Gutschow C and Schroder W: Laparoscopic ischemic conditioning of the stomach for esophageal replacement. Ann Surg. 245:241–246. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Shapiro J, van Lanschot JJB, Hulshof MCCM, van Hagen P, van Berge Henegouwen MI, Wijnhoven BPL, van Laarhoven HWM, Nieuwenhuijzen GAP, Hospers GAP, Bonenkamp JJ, et al: Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): Long-term results of a randomised controlled trial. Lancet Oncol. 16:1090–1098. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Hoeppner J, Lordick F, Brunner T, Glatz T, Bronsert P, Rothling N, Schmoor C, Lorenz D, Ell C, Hopt UT and Siewert JR: ESOPEC: Prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286). BMC Cancer. 16:5032016. View Article : Google Scholar : PubMed/NCBI

25 

Wittekind C and Oberschmid B: Pathology and new UICC classification of esophageal carcinoma. Onkologe. 16:453–461. 2010. View Article : Google Scholar

26 

UICC, . TNM: Klassifikation maligner Tumoren. 8th. Wiley; 2017

27 

Schneider PM, Metzger R, Schaefer H, Baumgarten F, Vallbohmer D, Brabender J, Wolfgarten E, Bollschweiler E, Baldus SE, Dienes HP and Hoelscher AH: Response evaluation by endoscopy, rebiopsy, and endoscopic ultrasound does not accurately predict histopathologic regression after neoadjuvant chemoradiation for esophageal cancer. Ann Surg. 248:902–908. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Simon R, Mirlacher M and Sauter G: Tissue microarrays. Method Mol Med. 114:257–268. 2005.

29 

Helbig D, Ihle MA, Putz K, Tantcheva-Poor I, Mauch C, Buttner R and Quaas A: Oncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal sarcomas. Oncotarget. 7:21763–21774. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Tureci O, Sahin U, Schulze-Bergkamen H, Zvirbule Z, Lordick F, Koeberle D, Thuss-Patience P, Ettrich T, Arnold D, Bassermann F, et al: A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: The MONO study. Ann Oncol. 30:1487–1495. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Fukayama M and Ushiku T: Epstein-Barr virus-associated gastric carcinoma. Pathol Res Pract. 207:529–537. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Cancer Genome Atlas Research Network, . Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 513:202–209. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Hewitt LC, Inam IZ, Saito Y, Yoshikawa T, Quaas A, Hoelscher A, Bollschweiler E, Fazzi GE, Melotte V, Langley RE, et al: Epstein-Barr virus and mismatch repair deficiency status differ between oesophageal and gastric cancer: A large multi-centre study. Eur J Cancer. 94:104–114. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Moentenich V, Gebauer F, Comut E, Tuchscherer A, Bruns C, Schroeder W, Buettner R, Alakus H, Loeser H, Zander T, Zander T, et al: Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies. Oncol Lett 19: 3665-3670, 2020.
APA
Moentenich, V., Gebauer, F., Comut, E., Tuchscherer, A., Bruns, C., Schroeder, W. ... Quaas, A. (2020). Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies. Oncology Letters, 19, 3665-3670. https://doi.org/10.3892/ol.2020.11520
MLA
Moentenich, V., Gebauer, F., Comut, E., Tuchscherer, A., Bruns, C., Schroeder, W., Buettner, R., Alakus, H., Loeser, H., Zander, T., Quaas, A."Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies". Oncology Letters 19.6 (2020): 3665-3670.
Chicago
Moentenich, V., Gebauer, F., Comut, E., Tuchscherer, A., Bruns, C., Schroeder, W., Buettner, R., Alakus, H., Loeser, H., Zander, T., Quaas, A."Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies". Oncology Letters 19, no. 6 (2020): 3665-3670. https://doi.org/10.3892/ol.2020.11520
Copy and paste a formatted citation
x
Spandidos Publications style
Moentenich V, Gebauer F, Comut E, Tuchscherer A, Bruns C, Schroeder W, Buettner R, Alakus H, Loeser H, Zander T, Zander T, et al: Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies. Oncol Lett 19: 3665-3670, 2020.
APA
Moentenich, V., Gebauer, F., Comut, E., Tuchscherer, A., Bruns, C., Schroeder, W. ... Quaas, A. (2020). Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies. Oncology Letters, 19, 3665-3670. https://doi.org/10.3892/ol.2020.11520
MLA
Moentenich, V., Gebauer, F., Comut, E., Tuchscherer, A., Bruns, C., Schroeder, W., Buettner, R., Alakus, H., Loeser, H., Zander, T., Quaas, A."Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies". Oncology Letters 19.6 (2020): 3665-3670.
Chicago
Moentenich, V., Gebauer, F., Comut, E., Tuchscherer, A., Bruns, C., Schroeder, W., Buettner, R., Alakus, H., Loeser, H., Zander, T., Quaas, A."Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies". Oncology Letters 19, no. 6 (2020): 3665-3670. https://doi.org/10.3892/ol.2020.11520
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