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Article

Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade

  • Authors:
    • Yuichi Ohnishi
    • Tsukasa Sakamoto
    • Li Zhengguang
    • Hiroki Yasui
    • Hiroyuki Hamada
    • Hirohito Kubo
    • Masahiro Nakajima
  • View Affiliations / Copyright

    Affiliations: Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Hirakata, Osaka 573‑1121, Japan, Department of Dentistry and Oral Surgery, Kansai Medical University Hospital, Hirakata, Osaka 573‑1010, Japan
  • Pages: 4177-4182
    |
    Published online on: April 7, 2020
       https://doi.org/10.3892/ol.2020.11523
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Abstract

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. OSCC cells are highly invasive, a characteristic that involves epithelial‑mesenchymal transition (EMT); the conversion of immotile epithelial cells into motile mesenchymal cells. EMT is involved in the progression of various types of cancer by promoting tumour cell scattering and conferring to these cells cancer stem cell (CSC)‑like characteristics, such as self‑renewal. Hepatocyte growth factor (HGF) signalling plays an important role in EMT induction and, therefore, contributes to cell invasion and metastasis in cancer. Due to its potential chemopreventative and anti‑tumour activities, curcumin has attracted much interest and has been shown to act as a potent EMT inhibitor in various types of cancer. However, at present, the potential effects of curcumin on HGF‑induced EMT in OSCC have not been investigated. Here, we demonstrated that HGF signalling could induce EMT in the HSC4 and Ca9‑22 OSCC cell lines via the HGF receptor c‑Met and downstream activation of the pro‑survival ERK pathway. Notably, curcumin inhibited HGF‑induced EMT and cell motility in HSC‑4 and Ca9‑22 cells via c‑Met blockade. Therefore, these findings establish curcumin as a candidate drug for OSCC treatment. Furthermore, curcumin was able to effectively inhibit the HGF‑induced increase in the levels of vimentin by downregulating the expression of phosphorylated c‑Met, an ERK. In conclusion, the results of the present study demonstrated that curcumin was able to reverse HGF‑induced EMT, possibly by inhibiting c‑Met expression in oral cancer cells, providing a strong basis for the development of novel approaches for the treatment of oral cancer.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Cohen EE, Lingen MW and Vokes EE: The expanding role of systemic therapy in head and neck cancer. J Clin Oncol. 22:1743–1752. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Kramer RH, Shen X and Zhou H: Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev. 24:35–45. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Ziober AF, Falls EM and Ziober BL: The extracellular matrix in oral squamous cell carcinoma: Friend or foe? Head Neck. 28:740–749. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Acloque H, Adams MS, Fishwick K, Bronner-Fraser M and Nieto MA: Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease. J Clin Invest. 119:1438–1449. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Thiery JP: Epithelial-mesenchymal transitions in tumor progression. Nat Rev Cancer. 2:442–454. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 7:131–142. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Krisanaprakornkit S and Iamaroon A: Epithelial-mesenchymal transition in oral squamous cell carcinoma. ISRN Oncol. 2012:6814692012.PubMed/NCBI

10 

Scheel C and Weinberg RA: Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links. Semin Cancer Biol. 22:396–403. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Morel AP, Lièvre M, Thomas C, Hinkal G, Ansieau S and Puisieux A: Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One. 3:e28882008. View Article : Google Scholar : PubMed/NCBI

14 

Huang X, Gan G, Wang X, Xu T and Xie W: The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. Autophagy. 15:1258–1279. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Ismail NI, Othman I, Abas F, H Lajis N and Naidu R: Mechanism of apoptosis induced by curcumin in colorectal cancer. Int J Mol Sci. 20:E24542019. View Article : Google Scholar : PubMed/NCBI

16 

Wong KE, Ngai SC, Chan KG, Lee LH, Goh BH and Chuah LH: Curcumin nanoformulations for colorectal cancer: A review. Front Pharmacol. 10:1522019. View Article : Google Scholar : PubMed/NCBI

17 

Bahrami A, Majeed M and Sahebkar A: Curcumin: A potent agent to reverse epithelial-to-mesenchymal transition. Cell Oncol. 42:405–421. 2019. View Article : Google Scholar

18 

Wang Q, Qu C, Xie F, Chen L, Liu L, Liang X, Wu X, Wang P and Meng Z: Curcumin suppresses epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells by inhibiting cancer-associated fibroblasts. Am J Cancer Res. 7:125–133. 2017.PubMed/NCBI

19 

Liang Z, Lu L, Mao J, Li X, Qian H and Xu W: Curcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt/β-catenin. Cell Death Dis. 8:e30662017. View Article : Google Scholar : PubMed/NCBI

20 

Jiao D, Wang J, Lu W, Tang X, Chen J, Mou H and Chen QY: Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancer. Mol Ther Oncolytics. 3:160182016. View Article : Google Scholar : PubMed/NCBI

21 

Ohnishi Y, Yasui H, Kakudo K and Nozaki M: Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway. Int J Oncol. 47:2165–2172. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Ohnishi Y, Yasui H, Kakudo K and Nozaki M: Regulation of cell migration via the EGFR signaling pathway in oral squamous cell carcinoma cells. Oncol Lett. 13:930–936. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Yasui H, Ohnishi Y, Nakajima M and Nozaki M: Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation. Oncol Rep. 37:3674–3680. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Tong W, Wang Q, Sun D and Suo J: Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-κB, uPA activator and MMP9. Oncol Lett. 12:4139–4146. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Yang J and Weinberg RA: Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell. 14:818–829. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Cano A, Pérez-Moreno MA, Rodrigo I, Locasioa A, Blanco MJ, del Barrio MG, Portillo F and Nieto MA: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2:76–83. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Nelson WJ and Nusse R: Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 303:1483–1487. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Shimada S, Mimata A, Sekine M, Mogushi K, Akiyama Y, Fukamachi H, Jonkers J, Tanaka H, Eishi Y and Yuasa Y: Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut. 61:344–353. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Organ SL and Tsao MS: An overview of the c-MET signaling pathway. Ther Adv Med Oncol. 3:S7–S19. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Baldanzi G and Graziani A: Physiological signaling and structure of the HGF receptor MET. Biomedicines. 3:1–31. 2015. View Article : Google Scholar

31 

Parikh RA, Wang P, Beumer JH, Chu E and Appleman LJ: The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment. Onco Targets Ther. 11:969–983. 2014.

32 

Stamenkovic I: Matrix metalloproteinases in tumor invasion and metastasis. Semin Cancer Biol. 10:415–433. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Moulik S, Pal S, Biswas J and Chatterjee A: Role of ERK in modulating MMP 2 and MMP 9 with respect to tumour invasiveness in human cancer cell line MCF-7 and MDA-MB-231. J Tumor. 2:87–98. 2014.

34 

Martin TA, Mason MD and Jiang WG: Hepatocyte growth factor signaling in cancer metastasis. Curr Signal Transduct Ther. 6:180–190. 2011. View Article : Google Scholar

35 

Grotegut S, von Schweinitz D, Christofori G and Lehembre F: Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail. EMBO J. 25:3534–3545. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Migliore C and Giordano S: Molecular cancer therapy: Can our expectation be MET? Eur J Cancer. 44:641–651. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Ohnishi Y, Lieger O, Attygalla M, Iizuka T and Kakudo K: Effects of epidermal growth factor on the invasion activity of the oral cancer cell lines HSC3 and SAS. Oral Oncol. 44:1155–1159. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Davies G, Watkins G, Mason MD and Jiang WG: Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells. Prostate. 60:317–324. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Park W, Amin AR, Chen ZG and Shin DM: New perspectives of curcumin in cancer prevention. Cancer Prev Res (Phila). 6:387–400. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Chen HW, Lee JY, Huang JY, Wang CC, Chen WJ, Su SF, Huang CW, Ho CC, Chen JJ, Tsai MF, et al: Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res. 68:7428–7438. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Ohnishi Y, Yasui H, Kakudo K and Nozaki M: Lapatinib-resistant cancer cells possessing epithelial cancer stem cell properties develop sensitivity during sphere formation by activation of the ErbB/AKT/cyclin D2 pathway. Oncol Rep. 36:3058–3064. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Siddappa G, Kulsum S, Ravindra DR, Kumar VV, Raju N, Raghavan N, Sudheendra HV, Sharma A, Sunny SP, Jacob T, et al: Curcumin and metformin-mediated chemoprevention of oral cancer is associated with inhibition of cancer stem cells. Mol Carcinog. 56:2446–2460. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ohnishi Y, Sakamoto T, Zhengguang L, Yasui H, Hamada H, Kubo H and Nakajima M: Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade. Oncol Lett 19: 4177-4182, 2020.
APA
Ohnishi, Y., Sakamoto, T., Zhengguang, L., Yasui, H., Hamada, H., Kubo, H., & Nakajima, M. (2020). Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade. Oncology Letters, 19, 4177-4182. https://doi.org/10.3892/ol.2020.11523
MLA
Ohnishi, Y., Sakamoto, T., Zhengguang, L., Yasui, H., Hamada, H., Kubo, H., Nakajima, M."Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade". Oncology Letters 19.6 (2020): 4177-4182.
Chicago
Ohnishi, Y., Sakamoto, T., Zhengguang, L., Yasui, H., Hamada, H., Kubo, H., Nakajima, M."Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade". Oncology Letters 19, no. 6 (2020): 4177-4182. https://doi.org/10.3892/ol.2020.11523
Copy and paste a formatted citation
x
Spandidos Publications style
Ohnishi Y, Sakamoto T, Zhengguang L, Yasui H, Hamada H, Kubo H and Nakajima M: Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade. Oncol Lett 19: 4177-4182, 2020.
APA
Ohnishi, Y., Sakamoto, T., Zhengguang, L., Yasui, H., Hamada, H., Kubo, H., & Nakajima, M. (2020). Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade. Oncology Letters, 19, 4177-4182. https://doi.org/10.3892/ol.2020.11523
MLA
Ohnishi, Y., Sakamoto, T., Zhengguang, L., Yasui, H., Hamada, H., Kubo, H., Nakajima, M."Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade". Oncology Letters 19.6 (2020): 4177-4182.
Chicago
Ohnishi, Y., Sakamoto, T., Zhengguang, L., Yasui, H., Hamada, H., Kubo, H., Nakajima, M."Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade". Oncology Letters 19, no. 6 (2020): 4177-4182. https://doi.org/10.3892/ol.2020.11523
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