Open Access

Clinical and prognostic association of oncogene cadherin 11 in gastric cancer

  • Authors:
    • Qiang Wang
    • Yingdong Jia
    • Xudong Peng
    • Chunhong Li
  • View Affiliations

  • Published online on: April 10, 2020     https://doi.org/10.3892/ol.2020.11531
  • Pages: 4011-4023
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The abnormal expression of cadherin‑11 (CDH11) affects the progression of several types of cancer. However, the expression pattern and prognostic value of CDH11 in gastric cancer (GC) have not been reported. In the present study, the expression of CDH11 in patients with GC and its effect on their survival were analyzed using public cancer databases. The expression of CDH11 in GC tissues was significantly higher compared with that in normal gastric tissues. The expression of CDH11 was higher in advanced GC compared with early GC, and increased CDH11 was associated with tumor progression and poor prognosis in patients with GC. The high level of methylation in the promoter of CDH11 in GC tissues was not sufficient to reverse the upregulation of CDH11 caused by transcriptional activation. Finally, the expression pattern and prognostic significance of CDH11 in GC were validated using data from patients with GC recruited for the present study. Collectively, the present results demonstrated that CDH11 was upregulated in GC tissues, and suggested that high CDH11 expression may be associated with progression and poor prognosis in GC.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang Q, Jia Y, Peng X and Li C: Clinical and prognostic association of oncogene cadherin 11 in gastric cancer. Oncol Lett 19: 4011-4023, 2020
APA
Wang, Q., Jia, Y., Peng, X., & Li, C. (2020). Clinical and prognostic association of oncogene cadherin 11 in gastric cancer. Oncology Letters, 19, 4011-4023. https://doi.org/10.3892/ol.2020.11531
MLA
Wang, Q., Jia, Y., Peng, X., Li, C."Clinical and prognostic association of oncogene cadherin 11 in gastric cancer". Oncology Letters 19.6 (2020): 4011-4023.
Chicago
Wang, Q., Jia, Y., Peng, X., Li, C."Clinical and prognostic association of oncogene cadherin 11 in gastric cancer". Oncology Letters 19, no. 6 (2020): 4011-4023. https://doi.org/10.3892/ol.2020.11531