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STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells

  • Authors:
    • Geng Guo
    • Shule Wang
    • Yining Hao
    • Yeqing Ren
    • Yongqiang Wu
    • Jianping Zhang
    • Dong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030000, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 248-256
    |
    Published online on: April 21, 2020
       https://doi.org/10.3892/ol.2020.11555
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Abstract

Aberrant expression of frequently rearranged in advanced T‑cell lymphomas 1 (FRAT1) contributes to poor prognosis in a number of carcinomas. However, its role in glioma remains controversial. In the present study, gene expression profiling was performed using Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO) functional enrichment and ingenuity pathway analysis (IPA) to evaluate the differential expression of genes and proteins in FRAT1 knockdown U251 glioma cells in comparison with the control. Western blot analysis was conducted to assess the expression levels of FRAT1 and STAT1. A total of 895 downregulated genes were identified in FRAT1‑silenced U251 cells. The most enriched processes determined by GO and KEGG analysis of the 895 differentially expressed genes were associated with proliferation, migration and invasion. According to IPA, significant canonical pathways, including the interferon, hepatic fibrosis and Wnt/β‑catenin signaling pathways, were identified to be the major enriched pathways. The elevated expression of STAT1 in U251 cells was validated. These results highlighted the regulatory role of FRAT1 in glioma cells with upregulated STAT1 expression.
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1 

Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC and Cavenee WK: The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol. 61:215–225; discussion 226-229. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Schiffer D: Classification and biology of astrocytic gliomas. Forum (Genova). 8:244–255. 1998.PubMed/NCBI

3 

Kleihues P, Soylemezoglu F, Schauble B, Scheithauer BW and Burger PC: Histopathology, classification, and grading of gliomas. Glia. 15:211–221. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Wiestler OD and Wolf HK: Revised WHO classification and new developments in diagnosis of central nervous system tumors. Pathologe. 16:245–255. 1995.(In German). View Article : Google Scholar : PubMed/NCBI

5 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Kleihues P and Ohgaki H: Primary and secondary glioblastomas: From concept to clinical diagnosis. Neuro Oncol. 1:44–51. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Durmaz R, Erken S, Arslantas A, Atasoy MA, Bal C and Tel E: Management of glioblastoma multiforme: With special reference to recurrence. Clin Neurol Neurosurg. 99:117–123. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Hsu E, Keene D, Ventureyra E, Matzinger MA, Jimenez C, Wang HS and Grimard L: Bone marrow metastasis in astrocytic gliomata. J Neurooncol. 37:285–293. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Jubelirer SJ: A review of the treatment and survival rates of 138 patients with glioblastoma multiforme. W V Med J. 92:186–190. 1996.PubMed/NCBI

10 

Park CC, Hartmann C, Folkerth R, Folkerth R, Loeffler JS, Wen PY, Fine HA, Black PM, Shafman T and Louis DN: Systemic metastasis in glioblastoma may represent the emergence of neoplastic subclones. J Neuropathol Exp Neurol. 59:1044–1050. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Scott JN, Rewcastle NB, Brasher PM, Fulton D, Hagen NA, MacKinnon JA, Sutherland G, Cairncross JG and Forsyth P: Long-term glioblastoma multiforme survivors: A population-based study. Can J Neurol Sci. 25:197–201. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Burton EC, Lamborn KR, Feuerstein BG, Prados M, Scott J, Forsyth P, Passe S, Jenkins RB and Aldape KD: Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma. Cancer Res. 62:6205–6210. 2002.PubMed/NCBI

13 

Krex D, Klink B, Hartmann C, von Deimling A, Pietsch T, Simon M, Sabel M, Steinbach JP, Heese O, Reifenberger G, et al: Long-term survival with glioblastoma multiforme. Brain. 130:2596–2606. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Bleeker FE, Molenaar RJ and Leenstra S: Recent advances in the molecular understanding of glioblastoma. J Neurooncol. 108:11–27. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, et al: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10:459–466. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Freemantle SJ, Portland HB, Ewings K, Dmitrovsky F, DiPetrillo K, Spinella MJ and Dmitrovsky E: Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. Gene. 291:17–27. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Yost C, Farr GH III, Pierce SB, Ferkey DM, Chen MM and Kimelman D: GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell. 93:1031–1041. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Yuan Y, Yang Z, Miao X, Li D, Liu Z and Zou Q: The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma. Tumour Biol. 36:9961–9968. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Jonkers J, van Amerongen R, van der Valk M, Robanus-Maandag E, Molenaar M, Destrée O and Berns A: In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3. Mech Dev. 88:183–194. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Saitoh T, Mine T and Katoh M: Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. Int J Oncol. 20:785–789. 2002.PubMed/NCBI

22 

Jonkers J, Korswagen HC, Acton D, Breuer M and Berns A: Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. EMBO J. 16:441–450. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Jonkers J, Weening JJ, van der Valk M, van der Valk M, Bobeldijk R and Berns A: Overexpression of Frat1 in transgenic mice leads to glomerulosclerosis and nephrotic syndrome, and provides direct evidence for the involvement of Frat1 in lymphoma progression. Oncogene. 18:5982–5990. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Wang Y, Hewitt SM, Liu S, Zhou X, Zhu H, Zhou C, Zhang G, Quan L, Bai J and Xu N: Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. Br J Cancer. 94:686–691. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Y, Han Y, Zheng R, Yu JH, Miao Y, Wang L and Wang EH: Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC. Tumour Biol. 33:1437–1444. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Zhang Y, Yu JH, Lin XY, Miao Y, Han Y, Fan CF, Dong XJ, Dai SD and Wang EH: Overexpression of Frat1 correlates with malignant phenotype and advanced stage in human non-small cell lung cancer. Virchows Arch. 459:255–263. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Fan WH, Du FJ, Liu XJ and Chen N: Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells. Oncol Rep. 36:2999–3004. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Guo G, Kuai D, Cai S, Xue N, Liu Y, Hao J, Fan Y, Jin J, Mao X, Liu B, et al: Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion. PLoS One. 8:e612062013. View Article : Google Scholar : PubMed/NCBI

29 

Gao YF, Mao XY, Zhu T, Mao CX, Liu ZX, Wang ZB, Li L, Li X, Yin JY, Zhang W, et al: COL3A1 and SNAP91: Novel glioblastoma markers with diagnostic and prognostic value. Oncotarget. 7:70494–70503. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Duarte CW, Willey CD, Zhi D, Cui X, Harris JJ, Vaughan LK, Mehta T, McCubrey RO, Khodarev NN, Weichselbaum RR and Gillespie GY: Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner. PLoS One. 7:e296532012. View Article : Google Scholar : PubMed/NCBI

31 

Wang L, Cao C, Ma Q, Zeng Q, Wang H, Cheng Z, Zhu G, Qi J, Ma H, Nian H and Wang Y: RNA-seq analyses of multiple meristems of soybean: Novel and alternative transcripts, evolutionary and functional implications. BMC Plant Biol. 14:1692014. View Article : Google Scholar : PubMed/NCBI

32 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Wu J, Mao X, Cai T, Luo J and Wei L: KOBAS server: A web-based platform for automated annotation and pathway identification. Nucleic Acids Res. 34:W720–W724. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Sherman BT, Huang da W, Tan Q, Guo Y, Bour S, Liu D, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID Knowledgebase: A gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis. BMC Bioinformatics. 8:4262007. View Article : Google Scholar : PubMed/NCBI

35 

Kramer A, Green J, Pollard J Jr and Tugendreich S: Causal analysis approaches in ingenuity pathway analysis. Bioinformatics. 30:523–530. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Culbert AA, Brown MJ, Frame S, Hagen T, Cross DA, Bax B and Reith AD: GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity. FEBS Lett. 507:288–294. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Hagen T, Cross DA, Culbert AA, West A, Frame S, Morrice N and Reith AD: FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. J Biol Chem. 281:35021–35029. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Li L, Yuan H, Weaver CD, Mao J, Farr GH III, Sussman DJ, Jonkers J, Kimelman D and Wu D: Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 18:4233–4240. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Thomas GM, Frame S, Goedert M, Nathke I, Polakis P and Cohen P: A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin. FEBS Lett. 458:247–251. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Jamieson C, Sharma M and Henderson BR: Wnt signaling from membrane to nucleus: β-catenin caught in a loop. Int J Biochem Cell Biol. 44:847–850. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Yong Z, Yu JH, Lin XY, Miao Y, Han Y, Fan CF, Dong XJ, Dai SD and Wang EH: Overexpression of Frat1 correlates with malignant phenotype and advanced stage in human non-small cell lung cancer. Virchows Archiv. 459:255–263. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Guo G, Liu B, Zhong C, Zhang X, Mao X, Wang P, Jiang X, Huo J, Jin J, Liu X and Chen X: FRAT1 expression and its correlation with pathologic grade, proliferation, and apoptosis in human astrocytomas. Med Oncol. 28:1–6. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Ihle JN: STATs: Signal transducers and activators of transcription. Cell. 84:331–334. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Bowman T, Garcia R, Turkson J and Jove R: STATs in oncogenesis. Oncogene. 19:2474–2488. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Matikainen S, Sareneva T, Ronni T, Lehtonen A, Koskinen PJ and Julkunen I: Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells. Blood. 93:1980–1991. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C and Darnell JE Jr: Stat3 as an oncogene. Cell. 98:295–303. 1999. View Article : Google Scholar : PubMed/NCBI

47 

Kharma B, Baba T, Matsumura N, Kang HS, Hamanishi J, Murakami R, McConechy MM, Leung S, Yamaguchi K, Hosoe Y, et al: STAT1 drives tumor progression in serous papillary endometrial cancer. Cancer Res. 74:6519–6530. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Lilly M and Kraft A: Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells. Cancer Res. 57:5348–5355. 1997.PubMed/NCBI

49 

Moroy T, Grzeschiczek A, Petzold S and Hartmann KU: Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice. Proc Natl Acad Sci USA. 90:10734–10738. 1993. View Article : Google Scholar : PubMed/NCBI

50 

Meng D, Chen Y, Yun D, Zhao Y, Wang J, Xu T, Li X, Wang Y, Yuan L, Sun R, et al: High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma. Oncotarget. 6:4901–4919. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Gouilleux-Gruart V, Gouilleux F, Desaint C, Claisse JF, Capiod JC, Delobel J, Weber-Nordt R, Dusanter-Fourt I, Dreyfus F, Groner B and Prin L: STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood. 87:1692–1697. 1996. View Article : Google Scholar : PubMed/NCBI

52 

Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS and Tweardy DJ: Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth In vitro. J Clin Invest. 102:1385–1392. 1998. View Article : Google Scholar : PubMed/NCBI

53 

Gouilleux-Gruart V, Debierre-Grockiego F, Gouilleux F, Capiod JC, Claisse JF, Delobel J and Prin L: Activated Stat related transcription factors in acute leukemia. Leuk Lymphoma. 28:83–88. 1997. View Article : Google Scholar : PubMed/NCBI

54 

Bromberg JF: Activation of STAT proteins and growth control. Bioessays. 23:161–169. 2001. View Article : Google Scholar : PubMed/NCBI

55 

Catlett-Falcone R, Dalton WS and Jove R: STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. Curr Opin Oncol. 11:490–496. 1999. View Article : Google Scholar : PubMed/NCBI

56 

Darnell JE Jr, Kerr IM and Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1415–1421. 1994. View Article : Google Scholar : PubMed/NCBI

57 

Hackenmiller R, Kim J, Feldman RA and Simon MC: Abnormal Stat activation, hematopoietic homeostasis, and innate immunity in c-fes-/- mice. Immunity. 13:397–407. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Delwar ZM, Kuo Y, Wen YH, Rennie PS and Jia W: Oncolytic virotherapy blockade by microglia and macrophages requires STAT1/3. Cancer Res. 78:718–730. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo G, Wang S, Hao Y, Ren Y, Wu Y, Zhang J and Liu D: STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells. Oncol Lett 20: 248-256, 2020.
APA
Guo, G., Wang, S., Hao, Y., Ren, Y., Wu, Y., Zhang, J., & Liu, D. (2020). STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells. Oncology Letters, 20, 248-256. https://doi.org/10.3892/ol.2020.11555
MLA
Guo, G., Wang, S., Hao, Y., Ren, Y., Wu, Y., Zhang, J., Liu, D."STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells". Oncology Letters 20.1 (2020): 248-256.
Chicago
Guo, G., Wang, S., Hao, Y., Ren, Y., Wu, Y., Zhang, J., Liu, D."STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells". Oncology Letters 20, no. 1 (2020): 248-256. https://doi.org/10.3892/ol.2020.11555
Copy and paste a formatted citation
x
Spandidos Publications style
Guo G, Wang S, Hao Y, Ren Y, Wu Y, Zhang J and Liu D: STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells. Oncol Lett 20: 248-256, 2020.
APA
Guo, G., Wang, S., Hao, Y., Ren, Y., Wu, Y., Zhang, J., & Liu, D. (2020). STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells. Oncology Letters, 20, 248-256. https://doi.org/10.3892/ol.2020.11555
MLA
Guo, G., Wang, S., Hao, Y., Ren, Y., Wu, Y., Zhang, J., Liu, D."STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells". Oncology Letters 20.1 (2020): 248-256.
Chicago
Guo, G., Wang, S., Hao, Y., Ren, Y., Wu, Y., Zhang, J., Liu, D."STAT1 is a modulator of the expression of frequently rearranged in advanced T‑cell lymphomas 1 expression in U251 cells". Oncology Letters 20, no. 1 (2020): 248-256. https://doi.org/10.3892/ol.2020.11555
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