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Article Open Access

miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9

  • Authors:
    • Jun Ma
    • Hong‑Feng Tong
    • Jie‑Huan Lin
    • Fu‑Nan Chen
    • Can‑Xing Wu
    • Cheng‑Zhang Cao
    • Jian Wu
    • Shu‑Qiao Hu
  • View Affiliations / Copyright

    Affiliations: Department of Cardio‑Thoracic Surgery, The First Hospital of Longyan City, Fujian Medical University, Longyan, Fujian 364000, P.R. China, Department of Thoracic Surgery, Beijing Hospital, Beijing 100730, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 299-307
    |
    Published online on: April 23, 2020
       https://doi.org/10.3892/ol.2020.11570
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Abstract

Previous studies reported a dysregulation of micro (mi)R-208b-5p expression level in various types of human cancer; however, the role of miR‑208‑5p in non‑small cell lung cancer (NSCLC) remains unclear. Therefore, the present study aimed to determine whether miR‑208b‑5p could regulate NSCLC progression. A total of 62 pairs of primary tumor and adjacent normal tissues were collected from patients with NSCLC. miR‑208b‑5p expression level was determined by reverse transcription‑quantitative polymerase chain reaction. Furthermore, miR‑208b‑5p mimics was transfected into NSCLC A549 and H1299 cells in order to upregulate miR‑208b‑5p expression. Dual‑luciferase reporter assay was utilized to investigate the associations between miR‑208b‑5p and IL9 mRNA. The results demonstrated that miR‑208b‑5p expression decreased in NSCLC tissues and cell lines. Furthermore, miR‑208b‑5p overexpression inhibited A549 and H1299 cell proliferation and invasiveness. miR‑208b‑5p was demonstrated to bind directly to the 3' untranslated region of interleukin‑9 (IL‑9) and therefore decreased its expression. In the NSCLC‑derived cell lines, miR‑208b‑5p inactivated IL‑9/signal transducer and activator of transcription 3 (STAT3) signaling pathway. Furthermore, enhanced IL‑9 level decreased the miR‑208b‑5p‑mediated suppression of epithelial‑mesenchymal transition in NSCLC cells by inactivating the STAT3 signaling pathway. In conclusion, the findings from this study demonstrated that miR‑208b‑5p inhibited migration and invasion of NSCLC cells. The anti‑tumor activity of miR‑208b‑5p may be mediated by IL‑9 and STAT‑3 pathway.
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1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Heist RS and Engelman JA: SnapShot: Non-small cell lung cancer. Cancer Cell. 21:448.e22012. View Article : Google Scholar : PubMed/NCBI

4 

Soroosh P and Doherty TA: Th9 and allergic disease. Immunology. 127:450–458. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Tete S, Saggini A, Maccauro G, Rosati M, Conti F, Cianchetti E, Tripodi D, Toniato E, Fulcheri M, Salini V, et al: Interleukin-9 and mast cells. J Biol Regul Homeost Agents. 26:319–326. 2012.PubMed/NCBI

6 

Knoops L and Renauld JC: IL-9 and its receptor: From signal transduction to tumorigenesis. Growth Factors. 22:207–215. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Chen N, Lu K, Li P, Lv X and Wang X: Overexpression of IL-9 induced by STAT6 activation promotes the pathogenesis of chronic lymphocytic leukemia. Int J Clin Exp Pathol. 7:2319–2323. 2014.PubMed/NCBI

8 

Zhang J, Wang WD, Geng QR, Wang L, Chen XQ, Liu CC and Lv Y: Serum levels of interleukin-9 correlate with negative prognostic factors in extranodal NK/T-cell lymphoma. PLoS One. 9:e946372014. View Article : Google Scholar : PubMed/NCBI

9 

Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB and Tweardy DJ: Stat3 signaling in acute myeloid leukemia: Ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 117:5701–5709. 2011. View Article : Google Scholar : PubMed/NCBI

10 

He Y, Yang Y, Xu J, Liao Y, Liu L, Deng L and Xiong X: IL22 drives cutaneous melanoma cell proliferation, migration and invasion through activation of miR-181/STAT3/AKT axis. J Cancer. 11:2679–2687. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Zheng S, Liu Q, Liu T, Yang L, Zhang Q, Shen T, Zhang X, Han X and Lu X: NME4 modulates PD-L1 expression via the STAT3 signaling pathway in squamous cell carcinoma. Biochem Biophys Res Commun. S0006-291X(30535-0)2020.[Epub ahead of print].

12 

Qu Y, He Y, Yang Y, Li S, An W, Li Z, Wang X, Han Z and Qin L: ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway. J Cancer. 11:2621–2631. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Fionda C, Malgarini G, Soriani A, Zingoni A, Cecere F, Iannitto ML, Ricciardi MR, Federico V, Petrucci MT, Santoni A and Cippitelli M: Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: Role of STAT3. J Immunol. 190:6662–6672. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Li W, Jia G, Qu Y, Du Q and Liu B and Liu B: Long non-coding RNA (LncRNA) HOXA11-AS promotes breast cancer invasion and metastasis by regulating epithelial-mesenchymal transition. Med Sci Monit. 23:3393–3403. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Zhao M, Ang L, Huang J and Wang J: MicroRNAs regulate the epithelial-mesenchymal transition and influence breast cancer invasion and metastasis. Tumour Biol. 39:10104283176916822017. View Article : Google Scholar : PubMed/NCBI

16 

Banyard J and Bielenberg DR: The role of EMT and MET in cancer dissemination. Connect Tissue Res. 56:403–413. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Croce CM: Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 10:704–714. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Ma J, Chen X, Xin G and Li X: Chronic exposure to the ionic liquid [C8mim]Br induces inflammation in silver carp spleen: Involvement of oxidative stress-mediated p38MAPK/NF-κB signalling and microRNAs. Fish Shellfish Immunol. 84:627–638. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Zhou YW, Zhang H, Duan CJ, Gao Y, Cheng YD, He D, Li R and Zhang CF: miR-675-5p enhances tumorigenesis and metastasis of esophageal squamous cell carcinoma by targeting REPS2. Oncotarget. 7:30730–30747. 2016.PubMed/NCBI

21 

Wen J, Hu Y, Liu Q, Ling Y, Zhang S, Luo K, Xie X, Fu J and Yang H: miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation. EBioMedicine. 37:110–124. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Chang RM, Xiao S, Lei X, Yang H, Fang F and Yang LY: miRNA-487a promotes proliferation and metastasis in hepatocellular carcinoma. Clin Cancer Res. 23:2593–2604. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Song H, Li D, Wu T, Xie D, Hua K, Hu J, Deng X, Ji C, Deng Y and Fang L: MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD. BMB Rep. 51:602–607. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Liu C, Zheng H, Xie L and Zhang J: Decreased miR-208 induced ischemia myocardial and reperfusion injury by targeting p21. Pharmazie. 71:719–723. 2016.PubMed/NCBI

25 

Yan X, Liu J, Wu H, Liu Y, Zheng S, Zhang C and Yang C: Impact of miR-208 and its target gene nemo-like kinase on the protective effect of ginsenoside Rb1 in hypoxia/ischemia injuried cardiomyocytes. Cell Physiol Biochem. 39:1187–1195. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Kakimoto Y, Tanaka M, Kamiguchi H, Hayashi H, Ochiai E and Osawa M: MicroRNA deep sequencing reveals chamber-specific miR-208 family expression patterns in the human heart. Int J Cardiol. 211:43–48. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Zhou C, Cui Q, Su G, Guo X, Liu X and Zhang J: MicroRNA-208b alleviates post-infarction myocardial fibrosis in a rat model by inhibiting GATA4. Med Sci Monit. 22:1808–1816. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Cai B, Pan Z and Lu Y: The roles of microRNAs in heart diseases: A novel important regulator. Curr Med Chem. 17:407–411. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Han M, Toli J and Abdellatif M: MicroRNAs in the cardiovascular system. Curr Opin Cardiol. 26:181–189. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Malizia AP and Wang DZ: MicroRNAs in cardiomyocyte development. Wiley Interdiscip Rev Syst Biol Med. 3:183–190. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Montgomery RL, Hullinger TG, Semus HM, Dickinson BA, Seto AG, Lynch JM, Stack C, Latimer PA, Olson EN and van Rooij E: Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation. 124:1537–1547. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

He D, Wang J, Zhang C, Shan B, Deng X, Li B, Zhou Y, Chen W, Hong J, Gao Y, et al: Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer. Mol Cancer. 14:732015. View Article : Google Scholar : PubMed/NCBI

34 

Chen W, Wang J, Liu S, Wang S, Cheng Y, Zhou W, Duan C and Zhang C: MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC. J Exp Clin Cancer Res. 35:762016. View Article : Google Scholar : PubMed/NCBI

35 

An X, Ge J, Guo H, Mi H, Zhou J, Liu Y, Weiyue and Wu Z: Overexpression of miR-4286 is an unfavorable prognostic marker in individuals with non-small cell lung cancer. J Cell Biochem. 120:17573–17583. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Dai FQ, Li CR, Fan XQ, Tan L, Wang RT and Jin H: miR-150-5p inhibits non-small-cell lung cancer metastasis and recurrence by targeting HMGA2 and β-catenin signaling. Mol Ther Nucleic Acids. 16:675–685. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Tan X, Jiang L, Wu X, Feng W and Lin Q: MicroRNA-625 inhibits the progression of non-small cell lung cancer by directly targeting HOXB5 and deactivating the Wnt/β-catenin pathway. Int J Mol Med. 44:346–356. 2019.PubMed/NCBI

38 

Yang Y, Li H, Liu Y, Chi C, Ni J and Lin X: miR-4319 hinders YAP expression to restrain non-small cell lung cancer growth through regulation of LIN28-mediated RFX5 stability. Biomed Pharmacother. 115:1089562019. View Article : Google Scholar : PubMed/NCBI

39 

Hornakova T, Staerk J, Royer Y, Flex E, Tartaglia M, Constantinescu SN, Knoops L and Renauld JC: Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. J Biol Chem. 284:6773–6781. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Chen N, Feng L, Qu H, Lu K, Li P, Lv X and Wang X: Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia. Oncol Rep. 39:3064–3072. 2018.PubMed/NCBI

41 

Pérez C, Mondéjar R, García-Díaz N, Cereceda L, León A, Montes S, Durán Vian C, Pérez Paredes MG, González-Morán A, Alegre de Miguel V, et al: Advanced-stage mycosis fungoides. Role of the signal transducer and activator of transcription 3, nuclear factor-κB and nuclear factor of activated T cells pathways. Br J Dermatol. 182:147–155. 2020.PubMed/NCBI

42 

Qin JJ, Yan L, Zhang J and Zhang WD: STAT3 as a potential therapeutic target in triple negative breast cancer: A systematic review. J Exp Clin Cancer Res. 38:1952019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma J, Tong HF, Lin JH, Chen FN, Wu CX, Cao CZ, Wu J and Hu SQ: miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9. Oncol Lett 20: 299-307, 2020.
APA
Ma, J., Tong, H., Lin, J., Chen, F., Wu, C., Cao, C. ... Hu, S. (2020). miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9. Oncology Letters, 20, 299-307. https://doi.org/10.3892/ol.2020.11570
MLA
Ma, J., Tong, H., Lin, J., Chen, F., Wu, C., Cao, C., Wu, J., Hu, S."miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9". Oncology Letters 20.1 (2020): 299-307.
Chicago
Ma, J., Tong, H., Lin, J., Chen, F., Wu, C., Cao, C., Wu, J., Hu, S."miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9". Oncology Letters 20, no. 1 (2020): 299-307. https://doi.org/10.3892/ol.2020.11570
Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Tong HF, Lin JH, Chen FN, Wu CX, Cao CZ, Wu J and Hu SQ: miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9. Oncol Lett 20: 299-307, 2020.
APA
Ma, J., Tong, H., Lin, J., Chen, F., Wu, C., Cao, C. ... Hu, S. (2020). miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9. Oncology Letters, 20, 299-307. https://doi.org/10.3892/ol.2020.11570
MLA
Ma, J., Tong, H., Lin, J., Chen, F., Wu, C., Cao, C., Wu, J., Hu, S."miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9". Oncology Letters 20.1 (2020): 299-307.
Chicago
Ma, J., Tong, H., Lin, J., Chen, F., Wu, C., Cao, C., Wu, J., Hu, S."miR‑208b‑5p inhibits invasion of non‑small cell lung cancer through the STAT3 pathway by targeting interleukin‑9". Oncology Letters 20, no. 1 (2020): 299-307. https://doi.org/10.3892/ol.2020.11570
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