Open Access

Distinct diagnostic and prognostic values of γ‑aminobutyric acid type A receptor family genes in patients with colon adenocarcinoma

  • Authors:
    • Ling Yan
    • Yi‑Zhen Gong
    • Meng‑Nan Shao
    • Guo‑Tian Ruan
    • Hai‑Lun Xie
    • Xi‑Wen Liao
    • Xiang‑Kun Wang
    • Quan‑Fa Han
    • Xin Zhou
    • Li‑Cheng Zhu
    • Feng Gao
    • Jia‑Liang Gan
  • View Affiliations

  • Published online on: April 24, 2020     https://doi.org/10.3892/ol.2020.11573
  • Pages: 275-291
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, the significance of GABAA genes in colon adenocarcinoma (COAD) were investigated from the view of diagnosis and prognosis. All data were achieved from The Cancer Genome Atlas. Overall survival was analyzed by the Kaplan‑Meier analyses and Cox regression model and the hazard ratios and 95% confidence interval were calculated for computation. The Database for Annotation, Visualization and Integrated Discovery, and the Biological Networks Gene Ontology (BiNGO) softwares were applied to assess the biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for pathway analysis to predict the biological function of GABAA genes. The associated Gene Ontology and KEGG pathways were conducted by Gene Set Enrichment Analysis (GSEA). From receiver operating characteristics curves analysis, it was found that the expression of GABR, γ‑aminobutyric acid type A receptor GABRA2, GABRA3, GABRB2, GABRB3, GABRG2, GABRG3, GABRD, GABRE were correlated with COAD occurrence [P<0.0001, area under the curve (AUC)>0.7]. The low expression of the GABRB1, GABRD, GABRP and GABRQ in genes after tumor staging adjustment were positively correlated with the overall survival rate [P=0.049, hazard ratio (HR)=1.517, 95% confidence interval (CI)=1.001‑2.297; P=0.006, HR=1.807, 95% CI=1.180‑2.765; P=0.005, HR=1.833, 95% CI=1.196‑2.810; P=0.034, HR=1.578, 95% CI=1.036‑2.405). GSEA showed enrichment of cell matrix adhesion, integrin binding, angiogenesis, endothelial growth factor and endothelial migration regulation in patients with COAD with GABRD overexpression. GABRB1, GABRD, GABRP and GABRQ were associated with the prognostic factors of COAD. The expression levels of GABRA2, GABRA3, GABRB2, GABRB3, GABRG2, GABRD and GABRE may allow differentiation between tumor tissues and adjacent normal tissues.

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July 2020
Volume 20 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Yan, L., Gong, Y., Shao, M., Ruan, G., Xie, H., Liao, X. ... Gan, J. (2020). Distinct diagnostic and prognostic values of γ‑aminobutyric acid type A receptor family genes in patients with colon adenocarcinoma. Oncology Letters, 20, 275-291. https://doi.org/10.3892/ol.2020.11573
MLA
Yan, L., Gong, Y., Shao, M., Ruan, G., Xie, H., Liao, X., Wang, X., Han, Q., Zhou, X., Zhu, L., Gao, F., Gan, J."Distinct diagnostic and prognostic values of γ‑aminobutyric acid type A receptor family genes in patients with colon adenocarcinoma". Oncology Letters 20.1 (2020): 275-291.
Chicago
Yan, L., Gong, Y., Shao, M., Ruan, G., Xie, H., Liao, X., Wang, X., Han, Q., Zhou, X., Zhu, L., Gao, F., Gan, J."Distinct diagnostic and prognostic values of γ‑aminobutyric acid type A receptor family genes in patients with colon adenocarcinoma". Oncology Letters 20, no. 1 (2020): 275-291. https://doi.org/10.3892/ol.2020.11573