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Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma

  • Authors:
    • Haibo Zhu
    • Yazhou Miao
    • Yutao Shen
    • Jing Guo
    • Weiyan Xie
    • Sida Zhao
    • Wei Dong
    • Yazhuo Zhang
    • Chuzhong Li
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100070, P.R. China, Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 561-568
    |
    Published online on: May 13, 2020
       https://doi.org/10.3892/ol.2020.11601
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Abstract

Pituitary adenoma and meningioma are two of the most common benign tumors in the central nervous system. Pituitary adenoma associated with meningioma (PAM) is a rare disease, the tumorigenesis of which remains unclear. Therefore, the aim of the present study was to investigate the tumorigenesis of PAM. A total of 8,197 patients with pituitary adenoma were analyzed. Furthermore, the clinical data of 57 patients with PAM were compared with patients with multiple endocrine neoplasia 1 (MEN‑1) syndrome. Whole exome sequencing (WES) was performed on 23 samples from patients with PAM and the germline mutation was verified by Sanger sequencing. The age of tumor penetrance (age of patients at diagnosis) for PAM was significantly higher than that for patients with MEN‑1. Compared with MEN‑1 patients, there was a significant association between PAM and female sex (P=0.004). Clonal analysis and phylogenetic tree construction suggested that the pituitary adenoma and meningioma in PAM don't originate from a common progenitor. WES revealed that 5/23 PAM samples had the recurrent germline mutation MEN1 c.1523G>A; p.G508D, which may be a genetic risk factor for PAM. Compared with patients with sporadic pituitary adenoma, the difference was statistically significant (P=0.0004). Compared with wild‑type MEN1, there was a significant association between the MEN1 mutation and recurrence of pituitary adenoma, young age and larger diameter of the meningioma. The present study indicated that germline mutations in MEN1 may be associated with the tumorigenesis of PAM.
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1 

McDowell BD, Wallace RB, Carnahan RM, Chrischilles EA, Lynch CF and Schlechte JA: Demographic differences in incidence for pituitary adenoma. Pituitary. 14:23–30. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Lecoq AL, Kamenický P, Guiochon-Mantel A and Chanson P: Genetic mutations in sporadic pituitary adenomas-what to screen for? Nat Rev Endocrinol. 11:43–54. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML and McCutcheon IE: The prevalence of pituitary adenomas: A systematic review. Cancer. 101:613–619. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Melmed S: Pathogenesis of pituitary tumors. Nat Rev Endocrinol. 7:257–266. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Amirjamshidi A, Mortazavi SA, Shirani M, Saeedinia S and Hanif H: ‘Coexisting pituitary adenoma and suprasellar meningioma-a coincidence or causation effect: Report of two cases and review of the literature’. J Surg Case Rep. 2017:rjx0392017. View Article : Google Scholar : PubMed/NCBI

6 

Ruiz-Juretschke F, Iza B, Scola-Pliego E, Poletti D and Salinero E: Coincidental pituitary adenoma and planum sphenoidale meningioma mimicking a single tumor. Endocrinol Nutr. 62:292–294. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Bondy M and Ligon BL: Epidemiology and etiology of intracranial meningiomas: A review. J Neurooncol. 29:197–205. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Curto L, Squadrito S, Almoto B, Longo M, Granata F, Salpietro F, Torre ML, Marini F, Trimarchi F and Cannavo S: MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: Report of a case. Pituitary. 10:299–305. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Herrero-Ruiz A, Villanueva-Alvarado HS, Corrales-Hernandez JJ, Higueruela-Minguez C, Feito-Perez J and Recio-Cordova JM: Coexistence of GH-producing pituitary macroadenoma and meningioma in a patient with multiple endocrine neoplasia type 1 with hyperglycemia and ketosis as first clinical sign. Case Rep Endocrinol. 2017:23907972017.PubMed/NCBI

10 

Concolino P, Costella A and Capoluongo E: Multiple endocrine neoplasia type 1 (MEN1): An update of 208 new germline variants reported in the last nine years. Cancer Genet. 209:36–41. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Agarwal SK: The future: Genetics advances in MEN1 therapeutic approaches and management strategies. Endocr Relat Cancer. 24:T119–T134. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Weber F and Mulligan LM: Happy 20th anniversary MEN1: From positional cloning to gene function restoration. Endocr Relat Cancer. 24:E7–E11. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Asgharian B, Chen YJ, Patronas NJ, Peghini PL, Reynolds JC, Vortmeyer A, Zhuang Z, Venzon DJ, Gibril F and Jensen RT: Meningiomas may be a component tumor of multiple endocrine neoplasia type 1. Clin Cancer Res. 10:869–880. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Goudet P, Bonithon-Kopp C, Murat A, Ruszniewski P, Niccoli P, Ménégaux F, Chabrier G, Borson-Chazot F, Tabarin A, Bouchard P, et al: Gender-related differences in MEN1 lesion occurrence and diagnosis: A cohort study of 734 cases from the groupe d'etude des tumeurs endocrines. Eur J Endocrinol. 165:97–105. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Li H and Durbin R: Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics. 26:589–595. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G and Durbin R; 1000 Genome Project Data Processing Subgroup, : The Sequence Alignment/Map format and SAMtools. Bioinformatics. 25:2078–2079. 2009. View Article : Google Scholar : PubMed/NCBI

17 

DePristo MA, Banks E, Poplin R, Garimella KV, Maguire JR, Hartl C, Philippakis AA, del Angel G, Rivas MA, Hanna M, et al: A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet. 43:491–498. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Cibulskis K, Lawrence MS, Carter SL, Sivachenko A, Jaffe D, Sougnez C, Gabriel S, Meyerson M, Lander ES and Getz G: Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol. 31:213–219. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Saunders CT, Wong WS, Swamy S, Becq J, Murray LJ and Cheetham RK: Strelka: Accurate somatic small-variant calling from sequenced tumor-normal sample pairs. Bioinformatics. 28:1811–1817. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Roth A, Khattra J, Yap D, Wan A, Laks E, Biele J, Ha G, Aparicio S, Bouchard-Côté A and Shah SP: PyClone: Statistical inference of clonal population structure in cancer. Nat Methods. 11:396–398. 2014. View Article : Google Scholar : PubMed/NCBI

21 

1000 Genomes Project Consortium, . Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT and McVean GA: An integrated map of genetic variation from 1,092 human genomes. Nature. 491:56–65. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, et al: Analysis of protein-coding genetic variation in 60,706 humans. Nature. 536:285–291. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Khandwala HM, McCutcheon IE, Flyvbjerg A and Friend KE: The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev. 21:215–244. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Ito T, Igarashi H, Uehara H, Berna MJ and Jensen RT: Causes of death and prognostic factors in multiple endocrine neoplasia type 1: A prospective study: Comparison of 106 MEN1/Zollinger-Ellison syndrome patients with 1613 literature MEN1 patients with or without pancreatic endocrine tumors. Medicine (Baltimore). 92:135–181. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Brandi ML, Gagel RF, Angeli A, Bilezikian JP, Beck-Peccoz P, Bordi C, Conte-Devolx B, Falchetti A, Gheri RG, Libroia A, et al: Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab. 86:5658–5671. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Giraud S, Choplin H, Teh BT, Lespinasse J, Jouvet A, Labat-Moleur F, Lenoir G, Hamon B, Hamon P and Calender A: A large multiple endocrine neoplasia type 1 family with clinical expression suggestive of anticipation. J Clin Endocrinol Metab. 82:3487–3492. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu H, Miao Y, Shen Y, Guo J, Xie W, Zhao S, Dong W, Zhang Y and Li C: Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma. Oncol Lett 20: 561-568, 2020.
APA
Zhu, H., Miao, Y., Shen, Y., Guo, J., Xie, W., Zhao, S. ... Li, C. (2020). Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma. Oncology Letters, 20, 561-568. https://doi.org/10.3892/ol.2020.11601
MLA
Zhu, H., Miao, Y., Shen, Y., Guo, J., Xie, W., Zhao, S., Dong, W., Zhang, Y., Li, C."Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma". Oncology Letters 20.1 (2020): 561-568.
Chicago
Zhu, H., Miao, Y., Shen, Y., Guo, J., Xie, W., Zhao, S., Dong, W., Zhang, Y., Li, C."Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma". Oncology Letters 20, no. 1 (2020): 561-568. https://doi.org/10.3892/ol.2020.11601
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu H, Miao Y, Shen Y, Guo J, Xie W, Zhao S, Dong W, Zhang Y and Li C: Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma. Oncol Lett 20: 561-568, 2020.
APA
Zhu, H., Miao, Y., Shen, Y., Guo, J., Xie, W., Zhao, S. ... Li, C. (2020). Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma. Oncology Letters, 20, 561-568. https://doi.org/10.3892/ol.2020.11601
MLA
Zhu, H., Miao, Y., Shen, Y., Guo, J., Xie, W., Zhao, S., Dong, W., Zhang, Y., Li, C."Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma". Oncology Letters 20.1 (2020): 561-568.
Chicago
Zhu, H., Miao, Y., Shen, Y., Guo, J., Xie, W., Zhao, S., Dong, W., Zhang, Y., Li, C."Germline mutations in MEN1 are associated with the tumorigenesis of pituitary adenoma associated with meningioma". Oncology Letters 20, no. 1 (2020): 561-568. https://doi.org/10.3892/ol.2020.11601
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