Abnormal polarization of macrophage‑like cells in the peripheral blood of patients with glioma

  • Authors:
    • Yawei Guo
    • Wenming Hong
    • Pengying Zhang
    • Dafei Han
    • Yilong Fang
    • Jiajie Tu
    • Wei Wei
  • View Affiliations

  • Published online on: May 13, 2020     https://doi.org/10.3892/ol.2020.11602
  • Pages: 947-954
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Abstract

Glioma is a type of malignant tumor arising from glial cells of the brain or the spine. Circulation‑derived macrophage infiltration is a characteristic of the glioma microenvironment. The polarization status of circulation‑derived macrophages in patients with glioma remains unclear. Therefore, the present study aimed to evaluate the polarization status of circulation‑derived macrophages in patients with glioma. A total of 40 patients with glioma and 38 healthy volunteers were recruited. The polarization status of macrophage‑­like cells in the peripheral blood of patients with glioma was evaluated. In addition, the associations between the polarization status of macrophage‑like cells and glioma stage or the expression levels of the glioma tumor marker chitinase‑3‑like protein 1 (also termed YKL‑40) were evaluated. The number of macrophage‑like cells (CD115+CD1c‑CD2‑CD15‑CD19‑CD14+­CD16+CD11b+) was higher in the peripheral blood of patients with glioma compared with that of healthy volunteers. There were fewer M1 macrophage‑like cells, and more M2 macrophage‑like cells were induced in the peripheral blood of patients with glioma compared with healthy controls. Specifically, the number of M2a/M2b macrophage‑like cells increased, whereas that of M2c macrophage‑like cells decreased in the peripheral blood of patients with glioma compared with healthy controls. The polarization status of macrophage‑like cells in patients with glioma was not significantly associated with glioma stage or with the glioma marker YKL‑40. Overall, the results of the present study revealed that the polarization status of macrophage‑like cells in the peripheral blood of patients with glioma was abnormal, offering potential novel diagnostic and therapeutic targets, such as different macrophage subsets, for glioma.

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July 2020
Volume 20 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Guo, Y., Hong, W., Zhang, P., Han, D., Fang, Y., Tu, J., & Wei, W. (2020). Abnormal polarization of macrophage‑like cells in the peripheral blood of patients with glioma. Oncology Letters, 20, 947-954. https://doi.org/10.3892/ol.2020.11602
MLA
Guo, Y., Hong, W., Zhang, P., Han, D., Fang, Y., Tu, J., Wei, W."Abnormal polarization of macrophage‑like cells in the peripheral blood of patients with glioma". Oncology Letters 20.1 (2020): 947-954.
Chicago
Guo, Y., Hong, W., Zhang, P., Han, D., Fang, Y., Tu, J., Wei, W."Abnormal polarization of macrophage‑like cells in the peripheral blood of patients with glioma". Oncology Letters 20, no. 1 (2020): 947-954. https://doi.org/10.3892/ol.2020.11602