Histology and its prognostic effect on KRAS‑mutated colorectal carcinomas in Korea
- Hye Seung Lee
- Dae Yong Hwang
- Hye Seung Han
Affiliations: Department of Pathology, Korea Clinical Laboratory, Seoul 05396, Republic of Korea, Department of Surgery, Konkuk University School of Medicine, Seoul 05030, Republic of Korea, Department of Pathology, Konkuk University School of Medicine, Seoul 05030, Republic of Korea
- Published online on: May 13, 2020 https://doi.org/10.3892/ol.2020.11606
Copyright: © Lee
et al. This is an open access article distributed under the
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KRAS mutation is frequently identified in advanced colorectal carcinoma (CRC); however, its prognostic significance and the associated histological features have remained to be clarified. In the present study, the precise histological results and prognostic value of KRAS‑mutated CRCs were investigated in patients from South Korea. A retrospective review of the results from KRAS mutation testing, as well as evaluation of the histology of 310 cases of CRC at various stages, were performed. Cross‑tabulation and survival analysis were performed according to the KRAS status. Patients with KRAS mutation more frequently exhibited serrated and papillary architectures (P=0.009 and P=0.014, respectively). KRAS mutation was an independent unfavorable prognostic factor for overall survival (OS) according to multivariate analysis (P=0.001), whereas no association was observed with disease‑free survival (DFS) (P=0.611). Of note, in the subgroup of KRAS‑mutated carcinomas, the presence of a solid component on histology was associated with less favorable OS (P=0.032). Furthermore, among the wild type cases, patients with a micropapillary component had a worse OS than those who did not (P=0.018). However, no subgroup or specific histological features were associated with DFS. In summary, KRAS‑mutated CRCs had a moderate association with particular histological features, and according to the KRAS mutational status, there was a certain degree of association between histology and prognosis.