Circular RNAs in gastric cancer: Biomarkers for early diagnosis (Review)
- Chun‑Mei Yang
- Guang‑Lei Qiao
- Li‑Na Song
- Shisan Bao
- Li‑Jun Ma
Affiliations: Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P.R. China
- Published online on: May 14, 2020 https://doi.org/10.3892/ol.2020.11623
Copyright: © Yang
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Circular RNAs (circRNAs) are highly conserved and stable closed-loop non-coding RNAs. They are involved in numerous biological functions, including regulating gene transcription or protein translation by interacting with proteins and regulating expression of microRNAs. The aberrant expression of circRNAs has been reported in many cancers, including gastric cancer. By regulating gene expression, circRNAs are able to affect the proliferation, invasion and metastasis of gastric cancer. The current review focused on the characteristics and biological functions of circRNAs, the carcinogenic potential and the possible implications of circRNAs on the diagnosis and treatment of gastric cancer. In conclusion, circRNAs may serve as potential biomarkers for diagnosis, as well as therapeutic targets.