Circular RNAs in gastric cancer: Biomarkers for early diagnosis (Review)

Yang,Chun‑Mei; Qiao,Guang‑Lei; Song,Li‑Na; Bao,Shisan; Ma,Li‑Jun

doi:10.3892/ol.2020.11623

Circular RNAs in gastric cancer: Biomarkers for early diagnosis (Review)

Authors:
- Chun‑Mei Yang
- Guang‑Lei Qiao
- Li‑Na Song
- Shisan Bao
- Li‑Jun Ma
View Affiliations

Affiliations: Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P.R. China
Published online on: May 14, 2020 https://doi.org/10.3892/ol.2020.11623
Pages: 465-473
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Circular RNAs (circRNAs) are highly conserved and stable closed-loop non-coding RNAs. They are involved in numerous biological functions, including regulating gene transcription or protein translation by interacting with proteins and regulating expression of microRNAs. The aberrant expression of circRNAs has been reported in many cancers, including gastric cancer. By regulating gene expression, circRNAs are able to affect the proliferation, invasion and metastasis of gastric cancer. The current review focused on the characteristics and biological functions of circRNAs, the carcinogenic potential and the possible implications of circRNAs on the diagnosis and treatment of gastric cancer. In conclusion, circRNAs may serve as potential biomarkers for diagnosis, as well as therapeutic targets.

View Figures

View References

1	Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
2	Zhu L, Qin J, Wang J, Guo T, Wang Z and Yang J: Early gastric cancer: Current advances of endoscopic diagnosis and treatment. Gastroenterol Res Pract. 2016:96380412016. View Article : Google Scholar : PubMed/NCBI
3	Huang RJ, Choi AY, Truong CD, Yeh MM and Hwang JH: Diagnosis and management of gastric intestinal metaplasia: Current status and future directions. Gut Liver. 15:596–603. 2019. View Article : Google Scholar
4	Hentze MW and Preiss T: Circular RNAs: Splicing's enigma variations. EMBO J. 32:923–925. 2013. View Article : Google Scholar : PubMed/NCBI
5	Vo JN, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, Wu YM, Dhanasekaran SM, Engelke CG, Cao X, et al: The landscape of circular RNA in cancer. Cell. 176:869–881. 2019. View Article : Google Scholar : PubMed/NCBI
6	Wilusz JE and Sharp PA: Molecular biology. A circuitous route to noncoding RNA. Science. 340:440–441. 2013. View Article : Google Scholar : PubMed/NCBI
7	Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature. 505:344–352. 2014. View Article : Google Scholar : PubMed/NCBI
8	Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA and Goodall GJ: The RNA binding protein quaking regulates formation of circRNAs. Cell. 160:1125–1134. 2015. View Article : Google Scholar : PubMed/NCBI
9	Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL and Sabeti PC: Strand-Specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. BMC Genomics. 16:4542015. View Article : Google Scholar : PubMed/NCBI
10	Lu T, Cui L, Zhou Y, Zhu C, Fan D, Gong H, Zhao Q, Zhou C, Zhao Y, Lu D, et al: Transcriptome-Wide investigation of circular RNAs in rice. RNA. 21:2076–2087. 2015. View Article : Google Scholar : PubMed/NCBI
11	Lu Z, Filonov GS, Noto JJ, Schmidt CA, Hatkevich TL, Wen Y, Jaffrey SR and Matera AG: Metazoan tRNA introns generate stable circular RNAs in vivo. RNA. 21:1554–1565. 2015. View Article : Google Scholar : PubMed/NCBI
12	Schmidt CA, Noto JJ, Filonov GS and Matera AG: A method for expressing and imaging abundant, stable, circular RNAs in vivo using tRNA splicing. Methods Enzymol. 572:215–236. 2016. View Article : Google Scholar : PubMed/NCBI
13	Jin M, Shi C, Yang C, Liu J and Huang G: Upregulated CircRNA ARHGAP10 Predicts an unfavorable prognosis in NSCLC through regulation of the miR-150-5p/GLUT-1 axis. Mol Ther Nucleic Acids. 18:219–231. 2019. View Article : Google Scholar : PubMed/NCBI
14	Ye F, Gao G, Zou Y, Zheng S, Zhang L, Ou X, Xie X and Tang H: CircFBXW7 inhibits malignant progression by sponging miR-197-3p and encoding a 185-aa protein in triple-negative breast cancer. Mol Ther Nucleic Acids. 18:88–98. 2019. View Article : Google Scholar : PubMed/NCBI
15	Zhu K, Zhan H, Peng Y, Yang L, Gao Q, Jia H, Dai Z, Tang Z, Fan J and Zhou J: Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma. Carcinogenesis. 19:1542019.
16	Chen J, Chen T, Zhu Y, Li Y, Zhang Y, Wang Y, Li X, Xie X, Wang J, Huang M, et al: CircPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma. J Exp Clin Cancer Res. 38:3982019. View Article : Google Scholar : PubMed/NCBI
17	Xu G, Chen Y, Fu M, Zang X, Cang M, Niu Y, Zhang W, Zhang Y, Mao Z, Shao M, et al: Circular RNA CCDC66 promotes gastric cancer progression by regulating c-Myc and TGF-β signaling pathways. J Cancer. 11:2759–2768. 2020. View Article : Google Scholar : PubMed/NCBI
18	Song H, Xu Y, Xu T, Fan R, Jiang T, Cao M, Shi L and Song J: CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p. Biomed Pharmacother. 126:1099412020. View Article : Google Scholar : PubMed/NCBI
19	Zhang L, Chang X, Zhai T, Yu J, Wang W, Du A and Liu N: A novel circular RNA, circ-ATAD1, contributes to gastric cancer cell progression by targeting miR-140-3p/YY1/PCIF1 signaling axis. Biochem Biophys Res Commun. 14:841–849. 2020. View Article : Google Scholar
20	Hu K, Qin X, Shao Y, Zhou Y, Ye G and Xu S: Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR-3200-5p and targeting PEBP1. Mol Cell Probes. 56:1015622020. View Article : Google Scholar
21	Ren S, Liu J, Feng Y, Li Z, He L, Li L, Cao X, Wang Z and Zhang Y: Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia. J Exp Clin Cancer Res. 38:3882019. View Article : Google Scholar : PubMed/NCBI
22	Liu Q, Zhang W, Wu Z, Liu H, Hu H, Shi H, Li S and Zhang X: Construction of a circular RNA-microRNA-messengerRNA regulatory network in stomach adenocarcinoma. J Cell Biochem. 12:1317–1331. 2019.
23	Bi J, Liu H, Dong W, Xie W, He Q, Cai Z, Huang J and Lin T: Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence. Mol Cancer. 18:1332019. View Article : Google Scholar : PubMed/NCBI
24	Huang H, Wei L, Qin T, Yang N, Li Z and Xu Z: Circular RNA ciRS-7 triggers the migration and invasion of esophageal squamous cell carcinoma via miR-7/KLF4 and NF-κB signals. Cancer Biol Ther. 20:73–80. 2019. View Article : Google Scholar : PubMed/NCBI
25	Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI
26	Chung DJ, Wang CJ, Yeh CW and Tseng TH: Inhibition of the proliferation and invasion of C6 glioma cells by tricin via the upregulation of focal-adhesion-kinase-targeting MicroRNA-7. J Agric Food Chem. 66:6708–6716. 2018. View Article : Google Scholar : PubMed/NCBI
27	Pan M, Li M, You C, Zhao F, Guo M, Xu H, Li L, Wang L and Dou J: Inhibition of breast cancer growth via miR-7 suppressing ALDH1A3 activity concomitant with decreasing breast cancer stem cell subpopulation. J Cell Physiol. 235:1405–1416. 2019. View Article : Google Scholar : PubMed/NCBI
28	Ye T, Yang M, Huang D, Wang X, Xue B, Tian N, Xu X, Bao L, Hu H, Lv T and Huang Y: MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer. J Exp Clin Cancer Res. 38:552019. View Article : Google Scholar : PubMed/NCBI
29	Ling Y, Cao C, Li S, Qiu M, Shen G, Chen Z, Yao F and Chen W: TRIP6, as a target of miR-7, regulates the proliferation and metastasis of colorectal cancer cells. Biochem Biophys Res Commun. 514:231–238. 2019. View Article : Google Scholar : PubMed/NCBI
30	Li Y, Zheng F, Xiao X, Xie F, Tao D, Huang C, Liu D, Wang M, Wang L, Zeng F and Jiang G: CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells. EMBO Rep. 18:1646–1659. 2017. View Article : Google Scholar : PubMed/NCBI
31	Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ and Liang L: Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget. 7:26680–26691. 2016. View Article : Google Scholar : PubMed/NCBI
32	Meng Q, Li S, Liu Y, Zhang S, Jin J, Zhang Y, Guo C, Liu B and Sun Y: Circular RNA circSCAF11 accelerates the glioma tumorigenesis through the miR-421/SP1/VEGFA axis. Mol Ther Nucleic Acids. 17:669–677. 2019. View Article : Google Scholar : PubMed/NCBI
33	Yan Y, Fu G, Ye Y and Ming L: Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer. Scand J Gastroenterol. 52:499–504. 2017. View Article : Google Scholar : PubMed/NCBI
34	Thomas LF and Sætrom P: Circular RNAs are depleted of polymorphisms at microRNA binding sites. Bioinformatics. 30:2243–2246. 2014. View Article : Google Scholar : PubMed/NCBI
35	Zhao ZJ and Shen J: Circular RNA participates in the carcinogenesis and the malignant behavior of cancer. RNA Biol. 14:514–521. 2017. View Article : Google Scholar : PubMed/NCBI
36	Lu J, Wang YH, Huang XY, Xie JW, Wang JB, Lin JX, Chen QY, Cao LL, Huang CM, Zheng CH and Li P: Circ-CEP85L suppresses the proliferation and invasion of gastric cancer by regulating NFKBIA expression via miR-942-5p. J Cell Physiol. 5:102020.
37	Li H, Wei X, Yang J, Dong D, Hao D, Huang Y, Lan X, Plath M, Lei C, Ma Y, et al: CircFGFR4 promotes differentiation of myoblasts via binding miR-107 to relieve its inhibition of Wnt3a. Mol Ther Nucleic Acids. 11:272–283. 2018. View Article : Google Scholar : PubMed/NCBI
38	Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N and Kadener S: Circrna biogenesis competes with pre-mRNA splicing. Mol Cell. 56:55–66. 2014. View Article : Google Scholar : PubMed/NCBI
39	Zheng J, Liu X, Xue Y, Gong W, Ma J, Xi Z, Que Z and Liu Y: TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway. J Hematol Oncol. 10:522017. View Article : Google Scholar : PubMed/NCBI
40	Yang ZG, Awan FM, Du WW, Zeng Y, Lyu J, Wu, Gupta S, Yang W and Yang BB: The Circular RNA interacts with stat3, increasing its nuclear translocation and wound repair by modulating Dnmt3a and miR-17 function. Mol Ther. 25:2062–2074. 2017. View Article : Google Scholar : PubMed/NCBI
41	Liu KS, Pan F, Mao XD, Liu C and Chen J: Biological functions of circular RNAs and their roles in occurrence of reproduction and gynecological diseases. Am J Transl Res. 11:1–15. 2019.PubMed/NCBI
42	Zhang Y, Liang W, Zhang P, Chen J, Qian H, Zhang X and Xu W: Circular RNAs: Emerging cancer biomarkers and targets. J Exp Clin Cancer Res. 36:1522017. View Article : Google Scholar : PubMed/NCBI
43	Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, et al: Translation of CircRNAs. Mol Cell. 66:9–21. 2017. View Article : Google Scholar : PubMed/NCBI
44	Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, et al: Extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Res. 27:626–641. 2017. View Article : Google Scholar : PubMed/NCBI
45	Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z and Sharpless NE: Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet. 6:e10012332010. View Article : Google Scholar : PubMed/NCBI
46	Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL and Gorospe M: Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol. 14:361–369. 2017. View Article : Google Scholar : PubMed/NCBI
47	Wang Y and Wang Z: Efficient backsplicing produces translatablecircular mRNAs. RNA. 21:172–179. 2015. View Article : Google Scholar : PubMed/NCBI
48	Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, et al: Exon-Intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 22:256–264. 2015. View Article : Google Scholar : PubMed/NCBI
49	Li F, Ma K, Sun M and Shi S: Identification of the tumor-suppressive function of circular RNA ITCH in glioma cells through sponging miR-214 and promoting linear ITCH expression. Am J Transl Res. 10:1373–1386. 2018.PubMed/NCBI
50	Ouyang Y, Li Y, Huang Y, Li X, Zhu Y, Long Y, Wang Y, Guo X and Gong K: CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR-186-5p and modulating NEK2. J Cell Physiol. 234:10458–10469. 2019. View Article : Google Scholar : PubMed/NCBI
51	Fry AM, O'Regan L, Sabir SR and Bayliss R: Cell cycle regulation by the NEK family of protein kinases. J Cell Sci. 125:4423–4433. 2012. View Article : Google Scholar : PubMed/NCBI
52	Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, et al: Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Lett. 388:208–219. 2017. View Article : Google Scholar : PubMed/NCBI
53	Liu H, Liu Y, Bian Z, Zhang J, Zhang R, Chen X, Huang Y, Wang Y and Zhu J: Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 (Kip1) axis. Mol Cancer. 17:1512018. View Article : Google Scholar : PubMed/NCBI
54	Zhang Y, Liu H, Li W, Yu J, Li J, Shen Z, Ye G, Qi X and Li G: CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. Aging (Albany NY). 9:1585–1594. 2017. View Article : Google Scholar : PubMed/NCBI
55	Wang L, Shen J and Jiang YL: Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1. Cell Biosci. 8:582018. View Article : Google Scholar : PubMed/NCBI
56	Yin QF, Yang L, Zhang Y, Xiang JF, Wu YW, Carmichael GG and Chen LL: Long noncoding RNAs with snoRNA ends. Mol Cell. 48:219–230. 2012. View Article : Google Scholar : PubMed/NCBI
57	Han B, Chao J and Yao H: Circular RNA and its mechanisms in disease: From the bench to the clinic. Pharmacol Ther. 187:31–44. 2018. View Article : Google Scholar : PubMed/NCBI
58	Sun HD, Xu ZP, Sun ZQ, Zhu B, Wang Q, Zhou J, Jin H, Zhao A, Tang WW and Cao XF: Down-Regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. Sci Rep. 8:101112018. View Article : Google Scholar : PubMed/NCBI
59	Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Zhou H, et al: A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun. 9:44752018. View Article : Google Scholar : PubMed/NCBI
60	Huang H, Weng H and Chen J: m⁶A Modification in coding and non-coding RNAs: Roles and therapeutic implications in cancer. Cancer Cell. 37:270–288. 2020. View Article : Google Scholar : PubMed/NCBI
61	Wu P, Mo Y, Peng M, Tang T, Zhong Y, Deng X, Xiong F, Guo C, Wu X, Li Y, et al: Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA. Mol Cancer. 19:222020. View Article : Google Scholar : PubMed/NCBI
62	Fang J, Hong H, Xue X, Zhu X, Jiang L, Qin M, Liang H and Gao L: A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. Cancer Lett. 442:222–232. 2019. View Article : Google Scholar : PubMed/NCBI
63	Warburg O, Wind F and Negelein E: The metabolism of tumors in the body. J Gen Physiol. 8:519–530. 1927. View Article : Google Scholar : PubMed/NCBI
64	Kimmelman AC and White E: Autophagy and tumor metabolism. Cell Metab. 25:1037–1043. 2017. View Article : Google Scholar : PubMed/NCBI
65	Zhang X, Wang S, Wang H, Cao J, Huang X, Chen Z, Xu P, Sun G, Xu J, Lv J and Xu Z: Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Mol Cancer. 18:202019. View Article : Google Scholar : PubMed/NCBI
66	Heras-Sandoval D, Perez-Rojas JM, Hernandez-Damian J and Pedraza-Chaverri J: The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal. 26:2694–2701. 2014. View Article : Google Scholar : PubMed/NCBI
67	Wu ZH, Lin C, Liu CC, Jiang WW, Huang MZ, Liu X and Guo WJ: MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway. Biochem Biophys Res Commun. 501:1068–1073. 2018. View Article : Google Scholar : PubMed/NCBI
68	Zhang H, Zhu L, Bai M, Liu Y, Zhan Y, Deng T, Yang H, Sun W, Wang X, Zhu K, et al: Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. Int J Cancer. 144:2501–2515. 2019. View Article : Google Scholar : PubMed/NCBI
69	Wei J, Wei W, Xu H, Wang Z, Gao W, Wang T, Zheng Q, Shu Y and De W: Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer. Cancer Biomark. 27:139–145. 2019. View Article : Google Scholar
70	Shao Y, Ye M, Li Q, Sun W, Ye G, Zhang X, Yang Y, Xiao B and Guo J: LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer. Oncotarget. 7:37812–37824. 2016. View Article : Google Scholar : PubMed/NCBI
71	Park YM, Kim JK, Baik SJ, Park JJ, Youn YH and Park H: Clinical risk assessment for gastric cancer in asymptomatic population after a health check-up: An individualized consideration of the risk factors. Medicine (Baltimore). 95:e53512016. View Article : Google Scholar : PubMed/NCBI
72	Shao Y, Li J, Lu R, Li T, Yang Y, Xiao B and Guo J: Global circular RNA expression profile of human gastric cancer and its clinical significance. Cancer Med. 6:1173–1180. 2017. View Article : Google Scholar : PubMed/NCBI
73	Duffy MJ, Lamerz R, Haglund C, Nicolini A, Kalousová M, Holubec L and Sturgeon C: Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update. Int J Cancer. 134:2513–2522. 2014. View Article : Google Scholar : PubMed/NCBI
74	Zhao Q, Chen S, Li T, Xiao B and Zhang X: Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal. 32:e223332018. View Article : Google Scholar : PubMed/NCBI
75	Lu J, Zhang PY, Xie JW, Wang JB, Lin JX, Chen QY, Cao LL, Huang CM, Li P and Zheng CH: Hsa_circ_0000467 promotes cancer progression and serves as a diagnostic and prognostic biomarker for gastric cancer. J Clin Lab Anal. 33:e227262019. View Article : Google Scholar : PubMed/NCBI
76	Tang W, Fu K, Sun H, Rong D, Wang H and Cao H: CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer. Mol Cancer. 17:1372018. View Article : Google Scholar : PubMed/NCBI
77	Yang W, Gu J, Wang X, Wang Y, Feng M, Zhou D, Guo J and Zhou M: Inhibition of circular RNA CDR1as increases chemosensitivity of 5-FU-resistant BC cells through up-regulating miR-7. J Cell Mol Med. 23:3166–3177. 2019. View Article : Google Scholar : PubMed/NCBI
78	Pan H, Li T, Jiang Y, Pan C, Ding Y, Huang Z, Yu H and Kong D: Overexpression of circular RNA ciRS-7 abrogates the tumor suppressive effect of miR-7 on gastric cancer via PTEN/PI3K/AKT signaling pathway. J Cell Biochem. 119:440–446. 2018. View Article : Google Scholar : PubMed/NCBI
79	Zhang H, Wang X, Huang H, Wang Y, Zhang F and Wang S: Hsa_circ_0067997 promotes the progression of gastric cancer by inhibition of miR-515-5p and activation of X chromosome-linked inhibitor of apoptosis (XIAP). Artif Cells Nanomed Biotechnol. 47:308–318. 2019. View Article : Google Scholar : PubMed/NCBI
80	Lencz T, Guha S, Liu C, Rosenfeld J, Mukherjee S, De Rosse P, John M, Cheng L, Zhang C, Badner JA, et al: Genome-Wide association study implicates NDST3 in schizophrenia and bipolar disorder. Nat Commun. 4:27392013. View Article : Google Scholar : PubMed/NCBI
81	Sun J, Li J, Zhang W, Zhang J, Sun S, Li G, Song H and Wan D: MicroRNA-509-3p inhibits cancer cell proliferation and migration via upregulation of XIAP in gastric cancer cells. Oncol Res. 25:455–461. 2017. View Article : Google Scholar : PubMed/NCBI
82	Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L and Huang Q: Circular RNAs expression profiles in human gastric cancer. Sci Rep. 7:90602017. View Article : Google Scholar : PubMed/NCBI
83	Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, et al: Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst. 110:32018. View Article : Google Scholar
84	Zhou C, Molinie B, Daneshvar K, Pondick JV, Wang J, Van Wittenberghe N, Xing Y, Giallourakis CC and Mullen AC: Genome-Wide maps of m6A circRNAs identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs. Cell Rep. 20:2262–2276. 2017. View Article : Google Scholar : PubMed/NCBI
85	Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X and Huang S: Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res. 25:981–984. 2015. View Article : Google Scholar : PubMed/NCBI
86	Li WH, Song YC, Zhang H, Zhou ZJ, Xie X, Zeng QN, Guo K, Wang T, Xia P and Chang DM: Decreased expression of Hsa_circ_00001649 in gastric cancer and its clinical significance. Dis Markers. 2017:45876982017. View Article : Google Scholar : PubMed/NCBI
87	Li J, Zhen L, Zhang Y, Zhao L, Liu H, Cai D, Chen H, Yu J, Qi X and Li G: Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells. Onco Targets Ther. 10:3521–3529. 2017. View Article : Google Scholar : PubMed/NCBI
88	Huang M, He YR, Liang LC, Huang Q and Zhu ZQ: Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol. 23:6330–6338. 2017. View Article : Google Scholar : PubMed/NCBI
89	Li P, Chen H, Chen S, Mo X, Li T, Xiao B, Yu R and Guo J: Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer. 116:626–633. 2017. View Article : Google Scholar : PubMed/NCBI
90	Li T, Shao Y, Fu L, Xie Y, Zhu L, Sun W, Yu R, Xiao B and Guo J: Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl). 96:85–96. 2018. View Article : Google Scholar : PubMed/NCBI
91	Fang Y, Ma M, Wang J, Liu X and Wang Y: Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Tumour Biol. 39:13933838142017. View Article : Google Scholar
92	Li P, Chen S, Chen H, Mo X, Li T, Shao Y, Xiao B and Guo J: Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Clin Chim Acta. 444:132–136. 2015. View Article : Google Scholar : PubMed/NCBI
93	Lu R, Shao Y, Ye G, Xiao B and Guo J: Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances. Tumour Biol. 39:13933854892017. View Article : Google Scholar
94	Sun H, Tang W, Rong D, Jin H, Fu K, Zhang W, Liu Z, Cao H and Cao X: Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark. 21:299–306. 2018. View Article : Google Scholar : PubMed/NCBI
95	Xie Y, Shao Y, Sun W, Ye G, Zhang X, Xiao B and Guo J: Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values. Biomark Med. 12:11–20. 2018. View Article : Google Scholar : PubMed/NCBI
96	Rong D, Dong C, Fu K, Wang H, Tang W and Cao H: Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells. Onco Targets Ther. 11:2753–2761. 2018. View Article : Google Scholar : PubMed/NCBI
97	Zhong S, Wang J, Hou J, Zhang Q, Xu H, Hu J, Zhao J and Feng J: Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells. Epigenomics. 10:1301–1313. 2018. View Article : Google Scholar : PubMed/NCBI
98	Wei H, Pan L, Tao D and Li R: Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression. Biochem Biophys Res Commun. 503:56–61. 2018. View Article : Google Scholar : PubMed/NCBI
99	Tian M, Chen R, Li T and Xiao B: Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance. J Clin Lab Anal. 32:32018. View Article : Google Scholar
100	Chen S, Li T, Zhao Q, Xiao B and Guo J: Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta. 466:167–171. 2017. View Article : Google Scholar : PubMed/NCBI
101	Zhou LH, Yang YC, Zhang RY, Wang P, Pang MH and Liang LQ: CircRNA_0023642 promotes migration and invasion of gastric cancer cells by regulating EMT. Eur Rev Med Pharmacol Sci. 22:2297–2303. 2018.PubMed/NCBI
102	Sun H, Xi P, Sun Z, Wang Q, Zhu B, Zhou J, Jin H, Zheng W, Tang W, Cao H and Cao X: Circ-SFMBT2 promotes the proliferation of gastric cancer cells through sponging miR-182-5p to enhance CREB1 expression. Cancer Manag Res. 10:5725–5734. 2018. View Article : Google Scholar : PubMed/NCBI
103	Shen F, Liu P, Xu Z, Li N, Yi Z, Tie X, Zhang Y and Gao L: CircRNA_001569 promotes cell proliferation through absorbing miR-145 in gastric cancer. J Biochem. 165:27–36. 2019. View Article : Google Scholar : PubMed/NCBI