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Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients

  • Authors:
    • Liqun Zhao
    • Yinglan Li
  • View Affiliations / Copyright

    Affiliations: Xiangya Nursing School, Central South University, Changsha, Hunan 410013, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1288-1294
    |
    Published online on: May 19, 2020
       https://doi.org/10.3892/ol.2020.11643
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Abstract

Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients was studied. Colon cancer cases (n=176) admitted to Xiangya Hospital Central South University were selected into the study. They were divided into group A (n=92) and group B (n=84). In group A, patients underwent surgery anesthesia with dexmedetomidine combined with sufentanil. In group B, patients underwent surgery anesthesia only with sufentanil. The anesthesia induced intubation, operation time and incidence of postoperative adverse reaction of patients were compared between the two groups. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were observed and recorded before induction, before intubation and after intubation. Blood coagulation analyzer was used to detect four items of coagulation before and after operation. FACSCalibur flow cytometry was used to detect T lymphocyte subsets in peripheral blood of patients in the two groups. The pain scores (VAS) of patients in the two groups were measured and recorded after surgery at 4, 24 and 48 h. There was a difference in anesthesia induced intubation and operation time of patients in both groups (P<0.05). There were differences in HR, SBP and DBP of patients in both groups after intubation (P<0.05), in postoperative coagulation function (P<0.05), and in postoperative immune function of patients in both groups (P<0.05). The VAS scores of patients in both groups were different at different time-points after operation (P<0.05). There were differences in postoperative adverse reactions of patients in both groups (P<0.05). Dexmedetomidine combined with sufentanil is a viable anesthetic regimen for colon cancer resection. The coagulation function and immune function have certain improvement effect for patients.
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1 

Marisa L, de Reyniès A, Duval A, Selves J, Gaub MP, Vescovo L, Etienne-Grimaldi MC, Schiappa R, Guenot D, Ayadi M, et al: Gene expression classification of colon cancer into molecular subtypes: Characterization, validation, and prognostic value. PLoS Med. 10:e10014532013. View Article : Google Scholar : PubMed/NCBI

2 

Sinicrope FA, Shi Q, Smyrk TC, Thibodeau SN, Dienstmann R, Guinney J, Bot BM, Tejpar S, Delorenzi M, Goldberg RM, et al: Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes. Gastroenterology. 148:88–99. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Warschkow R, Sulz MC, Marti L, Tarantino I, Schmied BM, Cerny T and Güller U: Better survival in right-sided versus left-sided stage I–III colon cancer patients. BMC Cancer. 16:5542016. View Article : Google Scholar : PubMed/NCBI

4 

Weerink MA, Struys MM, Hannivoort LN, Barends CR, Absalom AR and Colin P: Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clin Pharmacokinet. 56:893–913. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Keating GM: Dexmedetomidine: A review of its use for sedation in the intensive care setting. Drugs. 75:1119–1130. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Grant MJ, Schneider JB, Asaro LA, Dodson BL, Hall BA, Simone SL, Cowl AS, Munkwitz MM, Wypij D and Curley MA; Randomized Evaluation of Sedation Titration for Respiratory Failure Study Investigators, : Dexmedetomidine use in critically ill children with acute respiratory failure. Pediatr Crit Care Med. 17:1131–1141. 2016. View Article : Google Scholar : PubMed/NCBI

7 

van de Donk T, Ward S, Langford R and Dahan A: Pharmacokinetics and pharmacodynamics of sublingual sufentanil for postoperative pain management. Anaesthesia. 73:231–237. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Willsie SK, Evashenk MA, Hamel LG, Hwang SS, Chiang YK and Palmer PP: Pharmacokinetic properties of single- and repeated-dose sufentanil sublingual tablets in healthy volunteers. Clin Ther. 37:145–155. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Porela-Tiihonen S, Kokki M and Kokki H: Sufentanil sublingual formulation for the treatment of acute, moderate to severe postoperative pain in adult patients. Expert Rev Neurother. 17:101–111. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Ohnesorge H, Alpes A, Baron R and Gierthmühlen J: Influence of intraoperative remifentanil and sufentanil on sensory perception: A randomized trial. Curr Med Res Opin. 32:1797–1805. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Qin M, Chen K, Liu T and Shen X: Dexmedetomidine in combination with sufentanil for postoperative analgesia after partial laryngectomy. BMC Anesthesiol. 17:662017. View Article : Google Scholar : PubMed/NCBI

12 

Benson AB III, Venook AP, Cederquist L, Chan E, Chen YJ, Cooper HS, Deming D, Engstrom PF, Enzinger PC, Fichera A, et al: Colon cancer, version 1.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:370–398. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Schweiger MR, Hussong M, Röhr C and Lehrach H: Genomics and epigenomics of colorectal cancer. Wiley Interdiscip Rev Syst Biol Med. 5:205–219. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Soler M, Estevez MC, Villar-Vazquez R, Casal JI and Lechuga LM: Label-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal cancer. Anal Chim Acta. 930:31–38. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Arnarson Ö, Butt-Tuna S and Syk I: Postoperative complications following colonic resection for cancer are associated with impaired long-term survival. Colorectal Dis. 21:805–815. 2019.PubMed/NCBI

16 

Li L, Jin J, Min S, Liu D and Liu L: Compliance with the enhanced recovery after surgery protocol and prognosis after colorectal cancer surgery: A prospective cohort study. Oncotarget. 8:53531–53541. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Devcic A, Schmeling WT, Kampine JP and Warltier DC: Oral dexmedetomidine preserves baroreceptor function and decreases anesthetic requirements of halothane-anesthetized dogs. Anesthesiology. 81:419–430. 1994. View Article : Google Scholar : PubMed/NCBI

18 

Chen J, Fang JI, Lei Z, Zhang Z, Yiheshan A and Zhang B: Effect of dexmedetomidine on postoperative cellular immune function in patients with malignant tumor: A meta-analysis. Chin J Anesthesiol. 4:454–457. 2018.(In Chinese).

19 

Feng M, Chen X, Liu T, Zhang C, Wan L and Yao W: Dexmedetomidine and sufentanil combination versus sufentanil alone for postoperative intravenous patient-controlled analgesia: A systematic review and meta-analysis of randomized controlled trials. BMC Anesthesiol. 19:812019. View Article : Google Scholar : PubMed/NCBI

20 

Ma XX, Luo F and Lan R: Effects of dexmedetomidine combined with sufentanil on P2X7 receptor expression in peripheral blood mononuclear cells in patients with burn pain. Acta Microscopica. 28:2019.

21 

Dong CS, Zhang J, Lu Q, Sun P, Yu JM, Wu C and Sun H: Effect of dexmedetomidine combined with sufentanil for post-thoracotomy intravenous analgesia:a randomized, controlled clinical study. BMC Anesthesiol. 17:332017. View Article : Google Scholar : PubMed/NCBI

22 

Liuboshevskiĭ PA, Artamonova NI and Ovechkin AM: Haemostasis disturbances as the component of the surgical stress-response and possibilities of their correction. Anesteziol Reanimatol. 3:44–48. 2012.(In Russian).

23 

Chen Z, Shao D, Mao Z, Shi L, Zheng Y and Zhang D: Effect of dexmedetomidine on blood coagulation function following radical gastrectomy. J Clin Anesthesiol. 33:1086–1090. 2017.

24 

Sun HZ, Song YL and Wang XY: Effects of different anesthetic methods on cellular immune and neuroendocrine functions in patients with hepatocellular carcinoma before and after surgery. J Clin Lab Anal. 30:1175–1182. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Yang XH, Bai Q, Lv MM, Fu HG, Dong TL and Zhou Z: Effect of dexmedetomidine on immune function of patients undergoing radical mastectomy: a double blind and placebo control study. Eur Rev Med Pharmacol Sci. 21:1112–1116. 2017.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao L and Li Y: Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients. Oncol Lett 20: 1288-1294, 2020.
APA
Zhao, L., & Li, Y. (2020). Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients. Oncology Letters, 20, 1288-1294. https://doi.org/10.3892/ol.2020.11643
MLA
Zhao, L., Li, Y."Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients". Oncology Letters 20.2 (2020): 1288-1294.
Chicago
Zhao, L., Li, Y."Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients". Oncology Letters 20, no. 2 (2020): 1288-1294. https://doi.org/10.3892/ol.2020.11643
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L and Li Y: Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients. Oncol Lett 20: 1288-1294, 2020.
APA
Zhao, L., & Li, Y. (2020). Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients. Oncology Letters, 20, 1288-1294. https://doi.org/10.3892/ol.2020.11643
MLA
Zhao, L., Li, Y."Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients". Oncology Letters 20.2 (2020): 1288-1294.
Chicago
Zhao, L., Li, Y."Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients". Oncology Letters 20, no. 2 (2020): 1288-1294. https://doi.org/10.3892/ol.2020.11643
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