Open Access

Pan‑cancer analysis reveals the role of long non‑coding RNA LINC01614 as a highly cancer‑dependent oncogene and biomarker

  • Authors:
    • Dingding Wang
    • Hong Zhang
    • Xiaolian Fang
    • Dingfang Cao
    • Honggang Liu
  • View Affiliations

  • Published online on: May 20, 2020     https://doi.org/10.3892/ol.2020.11648
  • Pages: 1383-1399
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long intergenic non‑coding RNA 1614 (LINC01614) is highly expressed in several malignant tumor types, suggesting that it may act as an oncogene. However, the specific roles of LINC01614 in malignant tumors have remained elusive. To examine the expression pattern of LINC01614 in various malignancies, a comprehensive pan‑cancer analysis was performed using public databases, including 53 normal tissue types and 32 cancer datasets with samples from 9,091 patients. The results were validated using reverse transcription‑quantitative PCR analysis of tissue specimens from patients. LINC01614 expression was upregulated in most malignant tumors, thus demonstrating diagnostic potential. Furthermore, upregulation of LINC01614 was associated with poor overall survival in the majority of cases. However, the association with clinical outcome was highly cancer‑dependent; LINC01614 appeared to be an oncogene and diagnostic/prognostic biomarker in cancers of the digestive, respiratory, nervous and endocrine systems, as well as breast and head and neck cancer, but not in the cancers of the reproductive system or some of the urinary system. High LINC01614 expression was also markedly associated with the epithelial‑mesenchymal transition (EMT) and associated signaling pathways. Overall, the present results suggest that LINC01614 is an EMT‑associated oncogene that influences the metastasis and prognosis of several cancers, thus highlighting its potential as a novel diagnostic and prognostic marker.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang D, Zhang H, Fang X, Cao D and Liu H: Pan‑cancer analysis reveals the role of long non‑coding RNA LINC01614 as a highly cancer‑dependent oncogene and biomarker. Oncol Lett 20: 1383-1399, 2020
APA
Wang, D., Zhang, H., Fang, X., Cao, D., & Liu, H. (2020). Pan‑cancer analysis reveals the role of long non‑coding RNA LINC01614 as a highly cancer‑dependent oncogene and biomarker. Oncology Letters, 20, 1383-1399. https://doi.org/10.3892/ol.2020.11648
MLA
Wang, D., Zhang, H., Fang, X., Cao, D., Liu, H."Pan‑cancer analysis reveals the role of long non‑coding RNA LINC01614 as a highly cancer‑dependent oncogene and biomarker". Oncology Letters 20.2 (2020): 1383-1399.
Chicago
Wang, D., Zhang, H., Fang, X., Cao, D., Liu, H."Pan‑cancer analysis reveals the role of long non‑coding RNA LINC01614 as a highly cancer‑dependent oncogene and biomarker". Oncology Letters 20, no. 2 (2020): 1383-1399. https://doi.org/10.3892/ol.2020.11648