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Article Open Access

miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway

  • Authors:
    • Liangzhi Sun
    • Libo Wang
    • Suxian Luan
    • Yanzhou Jiang
    • Qiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Hetan Health Center, Weifang, Shandong 261100, P.R. China, Reproductive Medicine Centre, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Orthopedics, Hanting People's Hospital, Weifang, Shandong 261100, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2447-2455
    |
    Published online on: June 24, 2020
       https://doi.org/10.3892/ol.2020.11766
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Abstract

Osteosarcoma (OS) is the most commonly diagnosed malignant cancer of bone that occurs in adolescents and children. Mounting number of studies have indicated that miRNAs are increasingly playing fundamental roles in OS development. Thus, the biological function of miR‑429 in OS progression was explored. The results of RT‑qPCR revealed that miR‑429 was downregulated in OS tissues and OS cell lines (MG‑63, U2OS, Saos‑2) while homeobox A9 (HOXA9) was markedly increased. Moreover, HOXA9 was confirmed as a direct target of miR‑429 by using luciferase reporter assay. It was identified that miR‑429 exhibited a suppressive effect on OS progression while HOXA9 showed the oncogenic function in OS progression by using MTT and Transwell assays. More importantly, rescue assays manifested that HOXA9 can partially overturn the suppressive effect of miR‑429 on OS. Overexpression of miR‑429 inhibited the activation of Wnt/β‑catenin signaling pathway. In conclusion, miR‑429 suppressed OS progression by targeting HOXA9 through Wnt/β‑catenin pathway.
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View References

1 

Li J, Yang Z, Li Y, Xia J, Li D, Li H, Ren M, Liao Y, Yu S, Chen Y, et al: Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment. Oncotarget. 7:44763–44778. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Endo-Munoz L, Cumming A, Sommerville S, Dickinson I and Saunders NA: Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone. Br J Cancer. 103:73–81. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Vos HI, Coenen MJ, Guchelaar HJ and Te Loo DM: The role of pharmacogenetics in the treatment of osteosarcoma. Drug Discov Today. 21:1775–1786. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Amankwah EK, Conley AP and Reed DR: Epidemiology and therapies for metastatic sarcoma. Clin Epidemiol. 5:147–162. 2013.PubMed/NCBI

5 

Bishop MW, Janeway KA and Gorlick R: Future directions in the treatment of osteosarcoma. Curr Opin Pediatr. 28:26–33. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Isakoff MS, Bielack SS, Meltzer P and Gorlick R: Osteosarcoma: Current treatment and a collaborative pathway to success. J Clin Oncol. 33:3029–3035. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Mayer MN and Grier CK: Palliative radiation therapy for canine osteosarcoma. Can Vet J. 47:707–709. 2006.PubMed/NCBI

8 

Croce CM: Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 10:704–714. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Ning Q, Liu YF, Ye PJ, Gao P, Li ZP, Tang SY, He DX, Tang SS, Wei H and Yu CY: Delivery of liver-specific miRNA-122 using a targeted macromolecular prodrug toward synergistic therapy for hepatocellular carcinoma. ACS Appl Mater Interfaces. 11:10578–10588. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Lin X, Wang S, Sun M, Zhang C, Wei C, Yang C, Dou R, Liu Q and Xiong B: miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization. J Hematol Oncol. 12:202019. View Article : Google Scholar : PubMed/NCBI

11 

Zuo S, Dai G, Wang L, Wen Y, Huang Z, Yang W, Ma W and Ren X: Suppression of angiogenesis and tumor growth by recombinant T4 phages displaying extracellular domain of vascular endothelial growth factor receptor 2. Arch Virol. 164:69–82. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Weidhaas J: Using microRNAs to understand cancer biology. Lancet Oncol. 11:106–107. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Nana-Sinkam SP and Croce CM: MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: Towards clinical use. Genome Biol. 15:4452014. View Article : Google Scholar : PubMed/NCBI

15 

Huang D, Wang F, Wu W, Lian C and Liu E: MicroRNA-429 inhibits cancer cell proliferation and migration by targeting the AKT1 in melanoma. Cancer Biomark. 26:63–68. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Zong M, Liu Y, Zhang K, J Y and Chen L: The effects of miR-429 on cell migration and invasion by targeting Slug in esophageal squamous cell carcinoma. Pathol Res Pract. 215:1525262019. View Article : Google Scholar : PubMed/NCBI

17 

Su Z, Jiang G, Chen J, Liu X, Zhao H, Fang Z, He Y, Jiang X and Xu G: MicroRNA-429 inhibits cancer cell proliferation and migration by targeting AKT1 in renal cell carcinoma. Mol Clin Oncol. 12:75–80. 2020.PubMed/NCBI

18 

Liu X, Liu Y, Wu S, Shi X, Li L, Zhao J and Xu H: Tumor-suppressing effects of miR-429 on human osteosarcoma. Cell Biochem Biophys. 70:215–224. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Yu SL, Koo H, Lee HY, Yeom YI, Lee DC and Kang J: Recombinant cell-permeable HOXA9 protein inhibits NSCLC cell migration and invasion. Cell Oncol (Dordr). 42:275–285. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Makabe T, Arai E, Hirano T, Ito N, Fukamachi Y, Takahashi Y, Hirasawa A, Yamagami W, Susumu N, Aoki D, et al: Genome-wide DNA methylation profile of early-onset endometrial cancer: Its correlation with genetic aberrations and comparison with late-onset endometrial cancer. Carcinogenesis. 40:611–623. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Sun Y, Zhou B, Mao F, Xu J, Miao H, Zou Z, Phuc Khoa LT, Jang Y, Cai S, Witkin M, et al: HOXA9 reprograms the enhancer landscape to promote leukemogenesis. Cancer Cell. 34:643–658, e5. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Liu Y, Wang Y, Yang H, Zhao L, Song R, Tan H and Wang L: MicroRNA 873 targets HOXA9 to inhibit the aggressive phenotype of osteosarcoma by deactivating the Wnt/β catenin pathway. Int J Oncol. 54:1809–1820. 2019.PubMed/NCBI

23 

Yu J, Tian X, Chang J, Liu P and Zhang R: RUNX3 inhibits the proliferation and metastasis of gastric cancer through regulating miR-182/HOXA9. Biomed Pharmacother. 96:782–791. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Zheng DH, Wang X, Lu LN, Chen DL, Chen JM, Lin FM and Xu XB: MiR-638 serves as a tumor suppressor by targeting HOXA9 in glioma. Eur Rev Med Pharmacol Sci. 22:7798–7806. 2018.PubMed/NCBI

25 

Zhang ZF, Wang YJ, Fan SH, Du SX, Li XD, Wu DM, Lu J and Zheng YL: MicroRNA-182 downregulates Wnt/β-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9. Oncotarget. 8:101345–101361. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Gianferante DM, Mirabello L and Savage SA: Germline and somatic genetics of osteosarcoma - connecting aetiology, biology and therapy. Nat Rev Endocrinol. 13:480–491. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Lindsey BA, Markel JE and Kleinerman ES: Osteosarcoma overview. Rheumatol Ther. 4:25–43. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Gorlick R and Khanna C: Osteosarcoma. J Bone Miner Res. 25:683–691. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Liu X, Zhang C, Wang C, Sun J, Wang D, Zhao Y and Xu X: miR-210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncol Lett. 16:2229–2236. 2018.PubMed/NCBI

31 

Wang L, Hu K and Chao Y: MicroRNA-1301 inhibits migration and invasion of osteosarcoma cells by targeting BCL9. Gene. 679:100–107. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Alvarez-Garcia I and Miska EA: MicroRNA functions in animal development and human disease. Development. 132:4653–4662. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Wu G, Zheng H, Xu J, Guo Y, Zheng G, Ma C, Hao S, Liu X, Chen H, Wei S, et al: miR-429 suppresses cell growth and induces apoptosis of human thyroid cancer cells by targeting ZEB1. Artif Cells Nanomed Biotechnol. 47:548–554. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Shen F, Zheng H, Zhou L, Li W and Xu X: Overexpression of MALAT1 contributes to cervical cancer progression by acting as a sponge of miR-429. J Cell Physiol. 234:11219–11226. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Liu D, Song L, Dai Z, Guan H, Kang H, Zhang Y, Yan W, Zhao X and Zhang S: MiR-429 suppresses neurotrophin-3 to alleviate perineural invasion of pancreatic cancer. Biochem Biophys Res Commun. 505:1077–1083. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Deng Y, Luan F, Zeng L, Zhang Y and Ma K: MiR-429 suppresses the progression and metastasis of osteosarcoma by targeting ZEB1. EXCLI J. 16:618–627. 2017.PubMed/NCBI

37 

Pineault N, Helgason CD, Lawrence HJ and Humphries RK: Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny. Exp Hematol. 30:49–57. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Schneider E, Staffas A, Röhner L, Malmberg ED, Ashouri A, Krowiorz K, Pochert N, Miller C, Wei SY, Arabanian L, et al: Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia. Haematologica. 103:246–255. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Zhou L, Wang Y, Zhou M, Zhang Y, Wang P, Li X, Yang J, Wang H and Ding Z: HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development. Nat Commun. 9:14802018. View Article : Google Scholar : PubMed/NCBI

40 

Chong GO, Jeon HS, Han HS, Son JW, Lee YH, Hong DG, Park HJ, Lee YS and Cho YL: Overexpression of microRNA-196b accelerates invasiveness of cancer cells in recurrent epithelial ovarian cancer through regulation of homeobox A9. Cancer Genomics Proteomics. 14:137–141. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Thomsen CB, Andersen RF, Steffensen KD, Adimi P and Jakobsen A: Delta tocotrienol in recurrent ovarian cancer. A phase II trial. Pharmacol Res. 141:392–396. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Bhatlekar S, Ertel A, Gonye GE, Fields JZ and Boman BM: Gene expression signatures for HOXA4, HOXA9, and HOXD10 reveal alterations in transcriptional regulatory networks in colon cancer. J Cell Physiol. 234:13042–13056. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Yoshida A, Fujiwara T, Uotani K, Morita T, Kiyono M, Yokoo S, Hasei J, Nakata E, Kunisada T and Ozaki T: Clinical and functional significance of intracellular and extracellular microRNA-25-3p in osteosarcoma. Acta Med Okayama. 72:165–174. 2018.PubMed/NCBI

44 

Kureel J, John AA, Prakash R and Singh D: MiR 376c inhibits osteoblastogenesis by targeting Wnt3 and ARF-GEF-1-facilitated augmentation of beta-catenin transactivation. J Cell Biochem. 119:3293–3303. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Kushlinskii NE, Fridman MV and Braga EA: Molecular mechanisms and microRNAs in osteosarcoma pathogenesis. Biochemistry (Mosc). 81:315–328. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Liu X, Li L, Lv L, Chen D, Shen L and Xie Z: Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. Oncol Rep. 34:1035–1041. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Zhang J, Yu XH, Yan YG, Wang C and Wang WJ: PI3K/Akt signaling in osteosarcoma. Clin Chim Acta. 444:182–192. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Graziano AC, Cardile V, Avola R, Vicario N, Parenti C, Salvatorelli L, Magro G and Parenti R: Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. Oncotarget. 8:13917–13931. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, et al: Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci USA. 111:E5564–E5573. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun L, Wang L, Luan S, Jiang Y and Wang Q: miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway. Oncol Lett 20: 2447-2455, 2020.
APA
Sun, L., Wang, L., Luan, S., Jiang, Y., & Wang, Q. (2020). miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway. Oncology Letters, 20, 2447-2455. https://doi.org/10.3892/ol.2020.11766
MLA
Sun, L., Wang, L., Luan, S., Jiang, Y., Wang, Q."miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway". Oncology Letters 20.3 (2020): 2447-2455.
Chicago
Sun, L., Wang, L., Luan, S., Jiang, Y., Wang, Q."miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway". Oncology Letters 20, no. 3 (2020): 2447-2455. https://doi.org/10.3892/ol.2020.11766
Copy and paste a formatted citation
x
Spandidos Publications style
Sun L, Wang L, Luan S, Jiang Y and Wang Q: miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway. Oncol Lett 20: 2447-2455, 2020.
APA
Sun, L., Wang, L., Luan, S., Jiang, Y., & Wang, Q. (2020). miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway. Oncology Letters, 20, 2447-2455. https://doi.org/10.3892/ol.2020.11766
MLA
Sun, L., Wang, L., Luan, S., Jiang, Y., Wang, Q."miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway". Oncology Letters 20.3 (2020): 2447-2455.
Chicago
Sun, L., Wang, L., Luan, S., Jiang, Y., Wang, Q."miR‑429 inhibits osteosarcoma progression by targeting HOXA9 through suppressing Wnt/β‑catenin signaling pathway". Oncology Letters 20, no. 3 (2020): 2447-2455. https://doi.org/10.3892/ol.2020.11766
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