Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study

  • Authors:
    • Tomasz Kluz
    • Tomasz Łoziński
    • Sylwia Czekierdowska
    • Norbert Stachowicz
    • Grzegorz Gurynowicz
    • Mieczysław Chróściel
    • Artur Czekierdowski
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Fryderyk Chopin University Hospital No. 1, Faculty of Medicine, Rzeszow University, 35‑055 Rzeszow, Poland, Department of Obstetrics and Gynecology, Pro‑Familia Hospital, 35‑302 Rzeszow, Poland, Department of Gynecological Oncology and Gynecology, Poznan University of Medical Sciences, 60‑535 Poznan, Poland, Division of Perinatology and Women's Diseases, Poznan University of Medical Sciences, 60‑535 Poznan, Poland, Chair and Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, 20‑081 Lublin, Poland
    Copyright: © Kluz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2701-2710
    |
    Published online on: July 3, 2020
       https://doi.org/10.3892/ol.2020.11811
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to analyze the association between tumor budding index (TBI) and microvessel density (MVD) and selected clinicopathological features in female patients with endometrial cancer (EC). The present study included 137 patients, of whom 117 had endometrial endometrioid cancer and 3 had non‑endometrioid EC (NEEC). Additionally, 8 cases of simple endometrial hyperplasia and 9 cases of atypical endometrial hyperplasia were included in the present study. Patient age, menopausal status, tumor histological type, grade and International Federation of Gynecologists and Obstetricians (FIGO) clinical stage were investigated. Immunohistochemistry was utilized to detect MVD using a CD34 antibody, and a laminin‑5γ2 antibody was used for TBI assessment. In nonmalignant endometrial lesions, the TBI was significantly lower than that in patients with EC and NEEC (P=0.002). Significant differences in median TBI (MD‑TBI) were also observed between patients with low‑grade EC (MD‑TBI, 4.5) and high‑grade EC (MD‑TBI, 16.2; P=0.01). Age, body mass index and tumor FIGO stage were not indicated to be associated with the MD‑TBI. Premenopausal patients with EC had lower MD‑TBI values than postmenopausal patients (0.3 vs. 11.1; P<0.005). The median MVD‑CD34 in the study group was 19 (range, 13‑29). Significant differences in MVD‑CD34 were observed between malignant and nonmalignant endometrial lesions (P=0.01). Histological grade was markedly associated with tumor MVD‑CD34 (P=0.001). The MVD was higher in high‑grade cancer (G3; MVD‑CD34, 24.9) than in grade G1 and G2 lesions (MVD‑CD34, 14 and 18.6, respectively; P=0.01). FIGO clinical stage was not associated with MVD‑CD34 in low and high stage lesions (MD, 18.4 for FIGO stage I/II; MD, 17.6 for FIGO stage III/IV; P=0.2). High MVD was markedly associated with high MD‑TBI (P=0.0002). In conclusion, TBI could be a valuable indicator of tumor aggressiveness in patients with EC. The presence of the tumor budding phenomenon with increased MVD may have the potential to further refine clinical management decisions when endometrial malignancy is detected.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Torre LA, Islami F, Siegel RL, Ward EM and Jemal A: Global cancer in women: Burden and trends. Cancer Epidemiol Biomarkers Prev. 26:444–457. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Suarez AA, Felix AS and Cohn DE: Bokhman redux: Endometrial cancer ‘types’ in the 21st century. Gynecol Oncol. 144:243–249. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Emons G, Beckmann MW, Schmidt D and Mallmann P; Uterus commission of the Gynecological Oncology Working Group (AGO), : New WHO Classification of Endometrial Hyperplasias. Geburtshilfe Frauenheilkd. 75:135–136. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Felix AS, Yang HP, Bell DW and Sherman ME: Epidemiology of endometrial carcinoma: Etiologic importance of hormonal and metabolic influences. Adv Exp Med Biol. 943:3–46. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J, Marth C, Nout R, Querleu D, Mirza MR, et al ESMO-ESGO-ESTRO Endometrial Consensus Conference Working Group, : ESMO-ESGO-ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up. Int J Gynecol Cancer. 26:2–30. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Hase K, Shatney C, Johnson D, Trollope M and Vierra M: Prognostic value of tumor ‘budding’ in patients with colorectal cancer. Dis Colon Rectum. 36:627–635. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Ueno H, Murphy J, Jass JR, Mochizuki H and Talbot IC: Tumour ‘budding’ as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology. 40:127–132. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Yamaguchi Y, Ishii G, Kojima M, Yoh K, Otsuka H, Otaki Y, Aokage K, Yanagi S, Nagai K, Nishiwaki Y, et al: Histopathologic features of the tumor budding in adenocarcinoma of the lung: Tumor budding as an index to predict the potential aggressiveness. J Thorac Oncol. 5:1361–1368. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Gujam FJ, McMillan DC, Mohammed ZM, Edwards J and Going JJ: The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer. Br J Cancer. 113:1066–1074. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Lugli A, Kirsch R, Ajioka Y, Bosman F, Cathomas G, Dawson H, El Zimaity H, Fléjou JF, Hansen TP, Hartmann A, et al: Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Mod Pathol. 30:1299–1311. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Park JY, Hong DG, Chong GO and Park JY: Tumor budding is a valuable diagnostic parameter in prediction of disease progression of endometrial endometrioid carcinoma. Pathol Oncol Res. 25:723–730. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Lugli A, Vlajnic T, Giger O, Karamitopoulou E, Patsouris ES, Peros G, Terracciano LM and Zlobec I: Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients. Hum Pathol. 42:1833–1840. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Grigore AD, Jolly MK, Jia D, Farach-Carson MC and Levine H: Tumor budding: The name is EMT. Partial EMT. J Clin Med. 5:E512016. View Article : Google Scholar : PubMed/NCBI

15 

Gurzu S, Turdean S, Kovecsi A, Contac AO and Jung I: Epithelial-mesenchymal, mesenchymal-epithelial, and endothelial-mesenchymal transitions in malignant tumors: An update. World J Clin Cases. 3:393–404. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Koyuncuoglu M, Okyay E, Saatli B, Olgan S, Akin M and Saygili U: Tumor budding and E-Cadherin expression in endometrial carcinoma: Are they prognostic factors in endometrial cancer? Gynecol Oncol. 125:208–213. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Hallmann R, Horn N, Selg M, Wendler O, Pausch F and Sorokin LM: Expression and function of laminins in the embryonic and mature vasculature. Physiol Rev. 85:979–1000. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Miyazaki K: Laminin-5 (laminin-332): Unique biological activity and role in tumor growth and invasion. Cancer Sci. 97:91–98. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Masuda R, Kijima H, Imamura N, Aruga N, Nakazato K, Oiwa K, Nakano T, Watanabe H, Ikoma Y, Tanaka M, et al: Laminin-5γ2 chain expression is associated with tumor cell invasiveness and prognosis of lung squamous cell carcinoma. Biomed Res. 33:309–317. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Marangon Junior H, Rocha VN, Leite CF, de Aguiar MC, Souza PE and Horta MC: Laminin-5 gamma 2 chain expression is associated with intensity of tumor budding and density of stromal myofibroblasts in oral squamous cell carcinoma. J Oral Pathol Med. 43:199–204. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 29 (Suppl 16):15–18. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Demir R, Yaba A and Huppertz B: Vasculogenesis and angiogenesis in the endometrium during menstrual cycle and implantation. Acta Histochem. 112:203–214. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Mahecha AM and Wang H: The influence of vascular endothelial growth factor-A and matrix metalloproteinase-2 and −9 in angiogenesis, metastasis, and prognosis of endometrial cancer. OncoTargets Ther. 10:4617–4624. 2017. View Article : Google Scholar

24 

Viallard C and Larrivée B: Tumor angiogenesis and vascular normalization: Alternative therapeutic targets. Angiogenesis. 20:409–426. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Nagy JA and Dvorak HF: Heterogeneity of the tumor vasculature: The need for new tumor blood vessel type-specific targets. Clin Exp Metastasis. 29:657–662. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Zalewski K, Doniec J, Baranowski W and Bidziński M: The revised FIGO staging system for uterine malignancies. Ginekol Pol. 8:778–782. 2010.

27 

Czekierdowski A, Czekierdowska S, Czuba B, Cnota W, Sodowski K, Kotarski J and Zwirska-Korczala K: Microvessel density assessment in benign and malignant endometrial changes. J Physiol Pharmacol. 59 (Suppl 4):45–51. 2008.PubMed/NCBI

28 

Weidner N: Tumour vascularity and proliferation: Clear evidence of a close relationship. J Pathol. 189:297–299. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Karamitopoulou E, Zlobec I, Kölzer V, Kondi-Pafiti A, Patsouris ES, Gennatas K and Lugli A: Proposal for a 10-high-power-fields scoring method for the assessment of tumor budding in colorectal cancer. Mod Pathol. 26:295–301. 2013. View Article : Google Scholar : PubMed/NCBI

30 

de Boer SM, Powell ME, Mileshkin L, Katsaros D, Bessette P, Haie-Meder C, Ottevanger PB, Ledermann JA, Khaw P, Colombo A, et al PORTEC study group, : Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): An open-label, multicentre, randomised, phase 3 trial. Lancet Oncol. 17:1114–1126. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Huang B, Cai J, Xu X, Guo S and Wang Z: High-grade tumor budding stratifies early-stage cervical cancer with recurrence risk. PLoS One. 11:e01663112016. View Article : Google Scholar : PubMed/NCBI

32 

Zlobec I and Lugli A: Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget. Oncotarget. 1:651–661. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Mirantes C, Espinosa I, Ferrer I, Dolcet X, Prat J and Matias-Guiu X: Epithelial-to-mesenchymal transition and stem cells in endometrial cancer. Hum Pathol. 44:1973–1981. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Koelzer VH, Zlobec I, Berger MD, Cathomas G, Dawson H, Dirschmid K, Hädrich M, Inderbitzin D, Offner F, Puppa G, et al: Tumor budding in colorectal cancer revisited: Results of a multicenter interobserver study. Virchows Arch. 466:485–493. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Mazurek A and Kuć P: Angiogenesis-prognostic factor in patients with endometrial cancer. Ginekol Pol. 76:838–845. 2005.(In Polish). PubMed/NCBI

36 

Almangush A, Youssef O, M. Pirinen M, Sundström J, Leivo I and Mäkitie AA: Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review. Histopathology. 74:536–544. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Papa A, Zaccarelli E, Caruso D, Vici P, Benedetti Panici P and Tomao F: Targeting angiogenesis in endometrial cancer - new agents for tailored treatments. Expert Opin Investig Drugs. 25:31–49. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Lheureux S and Oza AM: Endometrial cancer-targeted therapies myth or reality? Review of current targeted treatments. Eur J Cancer. 59:99–108. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kluz T, Łoziński T, Czekierdowska S, Stachowicz N, Gurynowicz G, Chróściel M and Czekierdowski A: Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study. Oncol Lett 20: 2701-2710, 2020.
APA
Kluz, T., Łoziński, T., Czekierdowska, S., Stachowicz, N., Gurynowicz, G., Chróściel, M., & Czekierdowski, A. (2020). Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study. Oncology Letters, 20, 2701-2710. https://doi.org/10.3892/ol.2020.11811
MLA
Kluz, T., Łoziński, T., Czekierdowska, S., Stachowicz, N., Gurynowicz, G., Chróściel, M., Czekierdowski, A."Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study". Oncology Letters 20.3 (2020): 2701-2710.
Chicago
Kluz, T., Łoziński, T., Czekierdowska, S., Stachowicz, N., Gurynowicz, G., Chróściel, M., Czekierdowski, A."Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study". Oncology Letters 20, no. 3 (2020): 2701-2710. https://doi.org/10.3892/ol.2020.11811
Copy and paste a formatted citation
x
Spandidos Publications style
Kluz T, Łoziński T, Czekierdowska S, Stachowicz N, Gurynowicz G, Chróściel M and Czekierdowski A: Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study. Oncol Lett 20: 2701-2710, 2020.
APA
Kluz, T., Łoziński, T., Czekierdowska, S., Stachowicz, N., Gurynowicz, G., Chróściel, M., & Czekierdowski, A. (2020). Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study. Oncology Letters, 20, 2701-2710. https://doi.org/10.3892/ol.2020.11811
MLA
Kluz, T., Łoziński, T., Czekierdowska, S., Stachowicz, N., Gurynowicz, G., Chróściel, M., Czekierdowski, A."Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study". Oncology Letters 20.3 (2020): 2701-2710.
Chicago
Kluz, T., Łoziński, T., Czekierdowska, S., Stachowicz, N., Gurynowicz, G., Chróściel, M., Czekierdowski, A."Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study". Oncology Letters 20, no. 3 (2020): 2701-2710. https://doi.org/10.3892/ol.2020.11811
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team