Open Access

Systemic inflammatory indices predict tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer

  • Authors:
    • Sicong Lai
    • Liang Huang
    • Shuangling Luo
    • Zhanzhen Liu
    • Jianghui Dong
    • Liping Wang
    • Liang Kang
  • View Affiliations

  • Published online on: July 3, 2020     https://doi.org/10.3892/ol.2020.11812
  • Pages: 2763-2770
  • Copyright: © Lai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Systemic inflammatory responses are associated with the prognosis of patients with colorectal cancer. However, the value in predicting tumor responses to neoadjuvant chemoradiotherapy (nCRT) remains to be elucidated. The current study aimed to investigate the association between systemic inflammatory indices and pathological complete response (pCR). The training and validation cohorts included 225 and 96 patients with locally advanced rectal cancer. The neutrophil‑to‑lymphocyte ratio (NLR) and platelet‑to‑lymphocyte ratio were recorded prior to nCRT and radical surgery. Univariate and multivariate analysis were used to investigate the association between systemic inflammatory indices and pCR. Systemic inflammatory indices prior to or following treatment had no significant association with pCR; however, the percentage change in NLR from pre‑nCRT to post‑nCRT was associated with a poor response, and a percentage change of >21.5% NLR (P=0.006; OR=0.413; 95% CI=0.22‑0.773) was a predictor of poor pCR. Therefore, in rectal cancer, the percentage change in NLR from pre‑ to post‑nCRT was found to be a predictor of poor pCR.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lai S, Huang L, Luo S, Liu Z, Dong J, Wang L and Kang L: Systemic inflammatory indices predict tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Oncol Lett 20: 2763-2770, 2020
APA
Lai, S., Huang, L., Luo, S., Liu, Z., Dong, J., Wang, L., & Kang, L. (2020). Systemic inflammatory indices predict tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Oncology Letters, 20, 2763-2770. https://doi.org/10.3892/ol.2020.11812
MLA
Lai, S., Huang, L., Luo, S., Liu, Z., Dong, J., Wang, L., Kang, L."Systemic inflammatory indices predict tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer". Oncology Letters 20.3 (2020): 2763-2770.
Chicago
Lai, S., Huang, L., Luo, S., Liu, Z., Dong, J., Wang, L., Kang, L."Systemic inflammatory indices predict tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer". Oncology Letters 20, no. 3 (2020): 2763-2770. https://doi.org/10.3892/ol.2020.11812