Open Access

Shank‑associated RH domain interactor signaling in tumorigenesis (Review)

  • Authors:
    • Chong Zeng
    • Dan Xiong
    • Ketao Zhang
    • Jie Yao
  • View Affiliations

  • Published online on: July 9, 2020     https://doi.org/10.3892/ol.2020.11850
  • Pages: 2579-2586
  • Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Shank‑associated RH domain interactor (SHARPIN) is a component of the linear ubiquitin chain activation complex, which is essential for p53 signaling and inflammation. Previous studies have demonstrated that SHARPIN functions in tumor cell survival, growth, invasion and tumorigenesis. These functions include the regulation of p53 proteins via poly‑ubiquitination, interaction with a type II protein arginine methyltransferase 5 in melanoma cells, modulating ras‑associated protein‑1 through p38 and c‑Jun N‑terminal kinases/c‑Jun signaling, and mediating phosphoinositide 3‑kinase/AKT signaling via phosphatase and tensin homologue deleted on chromosome 10. Hence, SHARPIN not only participates in the inflammatory response but also serves a critical role in tumor cells. The present review summarizes the biological functions of the absence or presence of SHARPIN with regard to activating the canonical NF‑κB signaling pathway and the effects on p53 and other signaling pathways for the modulation of tumorigenesis. Therefore, this review provides insight into the underlying role and mechanisms of SHARPIN in tumorigenesis, as well as its potential application in cancer therapy.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zeng C, Xiong D, Zhang K and Yao J: Shank‑associated RH domain interactor signaling in tumorigenesis (Review). Oncol Lett 20: 2579-2586, 2020
APA
Zeng, C., Xiong, D., Zhang, K., & Yao, J. (2020). Shank‑associated RH domain interactor signaling in tumorigenesis (Review). Oncology Letters, 20, 2579-2586. https://doi.org/10.3892/ol.2020.11850
MLA
Zeng, C., Xiong, D., Zhang, K., Yao, J."Shank‑associated RH domain interactor signaling in tumorigenesis (Review)". Oncology Letters 20.3 (2020): 2579-2586.
Chicago
Zeng, C., Xiong, D., Zhang, K., Yao, J."Shank‑associated RH domain interactor signaling in tumorigenesis (Review)". Oncology Letters 20, no. 3 (2020): 2579-2586. https://doi.org/10.3892/ol.2020.11850