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SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway

  • Authors:
    • Jingzhi Wang
    • Rui Ling
    • Yuepeng Zhou
    • Xingyu Gao
    • Yun Yang
    • Chaoming Mao
    • Deyu Chen
  • View Affiliations / Copyright

    Affiliations: Institute of Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2855-2869
    |
    Published online on: July 10, 2020
       https://doi.org/10.3892/ol.2020.11853
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Abstract

Sterol regulatory element‑binding protein 1 (SREBP1) is dysregulated in a variety of types of human cancer. However, the functional roles of SREBP1 in esophageal squamous cell carcinoma (ESCC) remain poorly understood. The present study investigated the function of SREBP1 in cell proliferation and motility. Microarray datasets in Oncomine, reverse transcription‑quantitative PCR and western blot analysis revealed that SREBP1 was overexpressed in ESCC tumors when compared with normal tissues. In addition, SREBP1 overexpression was significantly associated with tumor differentiation, lymphatic metastasis and Ki67 expression. Results suggested that silencing SREBP1 inhibited the proliferation, migration and invasion of ESCC cells, whereas overexpression of SREBP1 had opposite effects on proliferation and metastasis. In addition, loss of SREBP1 significantly increased E‑cadherin and decreased N‑cadherin, Vimentin, Snail, matrix metalloproteinase 9 and vascular endothelial growth factor C expression levels, which were restored via SREBP1‑overexpression. Mechanistically, loss of SREBP1 suppressed T‑cell factor 1/lymphoid enhancer factor 1 (TCF1/LEF1) activity and downregulated TCF1/LEF1 target proteins, including CD44 and cyclin D1. Moreover, knockdown of SREBP1 downregulated the expression levels of stearoyl‑CoA desaturase 1 (SCD1), phosphorylated glycogen synthase kinase‑3β and nuclear β‑catenin. Furthermore, the inhibitors of SREBP1 and/or SCD1 and small interfering RNA‑SCD1 efficiently inhibited the activation of the Wnt/β‑catenin pathway driven by constitutively active SREBP1. Finally, in vivo results indicated that SREBP1‑knockdown suppressed the proliferation and metastasis of ESCC. Taken together, these findings demonstrated that SREBP1 exerts oncogenic effects in ESCC by promoting proliferation and inducing epithelial‑mesenchymal transition via the SCD1‑induced activation of the Wnt/β‑catenin signaling pathway.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68 (Suppl 8):S394–S424. 2018. View Article : Google Scholar

2 

Abnet CC, Arnold M and Wei WQ: Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 154:360–373. 2018. View Article : Google Scholar : PubMed/NCBI

3 

McGuire S: World cancer report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr. 7:418–419. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Wang H, Deng F, Liu Q and Ma Y: Prognostic significance of lymph node metastasis in esophageal squamous cell carcinoma. Pathol Res Pract. 213:842–847. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Hou H, Meng Z, Zhao X, Ding G, Sun M, Wang W and Wang Y: Survival of esophageal cancer in China: A pooled analysis on hospital-based studies from 2000 to 2018. Front Oncol. 9:5482019. View Article : Google Scholar : PubMed/NCBI

6 

Ordóñez-Morán P and Huelsken J: Complex metastatic niches: Already a target for therapy? Curr Opin Cell Biol. 31:29–38. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Chen D, Li W, Liu S, Su Y, Han G, Xu C, Liu H, Zheng T, Zhou Y and Mao C: Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway. Sci Rep. 5:86042015. View Article : Google Scholar : PubMed/NCBI

8 

Wang H, Yang X, Guo Y, Shui L, Li S, Bai Y, Liu Y, Zeng M and Xia J: HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K/AKT pathway. J Exp Clin Cancer Res. 38:3242019. View Article : Google Scholar : PubMed/NCBI

9 

Zhou H, Liu Y, Zhu R, Ding F, Cao X, Lin D and Liu Z: OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability. Oncogene. 37:3356–3368. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Li L, Zhou H, Zhu R and Liu Z: USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail. Cancer Lett. 448:52–60. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Ling R, Zhou Y, Zhou L, Dai D, Wu D, Mi L, Mao C and Chen D: Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma. Mol Med Rep. 17:5265–5271. 2018.PubMed/NCBI

12 

Pang L, Li Q, Li S, He J, Cao W, Lan J, Sun B, Zou H, Wang C, Liu R, et al: Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses. Sci Rep. 6:221792016. View Article : Google Scholar : PubMed/NCBI

13 

Dias IH, Borah K, Amin B, Griffiths HR, Sassi K, Lizard G, Iriondo A and Martinez-Lage P: Localisation of oxysterols at the sub-cellular level and in biological fluids. J Steroid Biochem Mol Biol. 193:1054262019. View Article : Google Scholar : PubMed/NCBI

14 

Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura SI, Natsume T, Miyamura N, Nishina H, Nakayama J, et al: Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Nat Commun. 8:12462017. View Article : Google Scholar : PubMed/NCBI

15 

Ma XL, Sun YF, Wang BL, Shen MN, Zhou Y, Chen JW, Hu B, Gong ZJ, Zhang X, Cao Y, et al: Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic target. BMC Cancer. 19:7602019. View Article : Google Scholar : PubMed/NCBI

16 

Dai S, Yan Y, Xu Z, Zeng S, Qian L, Huo L, Li X, Sun L and Gong Z: SCD1 confers temozolomide resistance to human glioma cells via the Akt/GSK3β/β-catenin signaling axis. Front Pharmacol. 8:9602018. View Article : Google Scholar : PubMed/NCBI

17 

Pisanu ME, Noto A, De Vitis C, Morrone S, Scognamiglio G, Botti G, Venuta F, Diso D, Jakopin Z, Padula F, et al: Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells. Cancer Lett. 406:93–104. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Noto A, De Vitis C, Pisanu ME, Roscilli G, Ricci G, Catizone A, Sorrentino G, Chianese G, Taglialatela-Scafati O, Trisciuoglio D, et al: Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ. Oncogene. 36:4573–4584. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Tao T, Su Q, Xu S, Deng J, Zhou S, Zhuang Y, Huang Y, He C, He S, Peng M, et al: Down-regulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis. J Cell Physiol. 234:3088–3104. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Zhu J, Jin J, Ding J, Li S, Cen P, Wang K, Wang H and Xia J: Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway. Chem-Biol Interact. 290:77–87. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Olmstead AD, Knecht W, Lazarov I, Dixit SB and Jean F: Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS Pathog. 8:e10024682012. View Article : Google Scholar : PubMed/NCBI

22 

Mustafa M, Wang TN, Chen X, Gao B and Krepinsky JC: SREBP inhibition ameliorates renal injury after unilateral ureteral obstruction. Am J Physiol Renal Physiol. 311:F614–F625. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Zhou C, Qian W, Ma J, Cheng L, Jiang Z, Yan B, Li J, Duan W, Sun L, Cao J, et al: Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1. Cell Prolif. 52:e125142019. View Article : Google Scholar : PubMed/NCBI

24 

Nie LY, Lu QT, Li WH, Yang N, Dongol S, Zhang X and Jiang J: Sterol regulatory element-binding protein 1 is required for ovarian tumor growth. Oncol Rep. 30:1346–1354. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Cheng C, Ru P, Geng F, Liu J, Yoo JY, Wu X, Cheng X, Euthine V, Hu P, Guo JY, et al: Glucose-Mediated N-glycosylation of SCAP is essential for SREBP-1 activation and tumor growth. Cancer Cell. 28:569–581. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Griffiths B, Lewis CA, Bensaad K, Ros S, Zhang Q, Ferber EC, Konisti S, Peck B, Miess H, East P, et al: Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab. 1:32013. View Article : Google Scholar : PubMed/NCBI

27 

Singh KB, Hahm ER, Pore SK and Singh SV: Leelamine is a novel lipogenesis inhibitor in prostate cancer cells in vitro and in vivo. Mol Cancer Ther. 18:1800–1810. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Gao Y, Nan X, Shi X, Mu X, Liu B, Zhu H, Yao B, Liu X, Yang T, Hu Y and Liu S: SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-kappaB pathway activation. BMC Cancer. 19:6852019. View Article : Google Scholar : PubMed/NCBI

29 

Yoshida GJ, Saya H and Zouboulis CC: Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling. Biochem Biophys Res Commun. 438:640–646. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Wang Y, Guo D, He J, Song L, Chen H, Zhang Z and Tan N: Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII. Biochem Biophys Res Commun. 512:819–824. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, Manfrin A, Ingallina E, Sommaggio R, Piazza S, et al: Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol. 16:357–366. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Bertolio R, Napoletano F, Mano M, Maurer-Stroh S, Fantuz M, Zannini A, Bicciato S, Sorrentino G and Del Sal G: Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism. Nat Commun. 10:13262019. View Article : Google Scholar : PubMed/NCBI

33 

Sodi VL, Bacigalupa ZA, Ferrer CM, Lee JV, Gocal WA, Mukhopadhyay D, Wellen KE, Ivan M and Reginato MJ: Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation. Oncogene. 37:924–934. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B and Oesterreich S: Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 20:1062018. View Article : Google Scholar : PubMed/NCBI

35 

Zhou C, Qian W, Li J, Ma J, Chen X, Jiang Z, Cheng L, Duan W, Wang Z, Wu Z, et al: High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer. J Exp Clin Cancer Res. 38:3022019. View Article : Google Scholar : PubMed/NCBI

36 

Gouw AM, Margulis K, Liu NS, Raman SJ, Mancuso A, Toal GG, Tong L, Mosley A, Hsieh AL, Sullivan DK, et al: The MYC oncogene cooperates with sterol-regulated element-binding protein to regulate lipogenesis essential for neoplastic growth. Cell Metab. 30:556–572.e5. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Hu N, Clifford RJ, Yang HH, Wang C, Goldstein AM, Ding T, Taylor PR and Lee MP: Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinoma. BMC Genomics. 11:5762010. View Article : Google Scholar : PubMed/NCBI

38 

Su H, Hu N, Yang HH, Wang C, Takikita M, Wang QH, Giffen C, Clifford R, Hewitt SM, Shou JZ, et al: Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes. Clin Cancer Res. 17:2955–2966. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Hu G, Zhou Y, Zhu Y, Zhou L, Ling R, Wu D, Mi L, Wang X, Dai D, Mao C and Chen D: Novel transduction of nutrient stress to Notch pathway by RasGRP3 promotes malignant aggressiveness in human esophageal squamous cell carcinoma. Oncol Rep. 38:2975–2984. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Zhou Y, Su Y, Zhu H, Wang X, Li X, Dai C, Xu C, Zheng T, Mao C and Chen D: Interleukin-23 receptor signaling mediates cancer dormancy and radioresistance in human esophageal squamous carcinoma cells via the Wnt/Notch pathway. J Mol Med (Berl). 97:177–188. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Brown M, Hart C, Tawadros T, Ramani V, Sangar V, Lau M and Clarke N: The differential effects of statins on the metastatic behaviour of prostate cancer. Br J Cancer. 106:1689–1696. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Huang CM, Huang CS, Hsu TN, Huang MS, Fong IH, Lee WH and Liu SC: Disruption of cancer metabolic SREBP1/miR-142-5p suppresses epithelial-mesenchymal transition and stemness in esophageal carcinoma. Cells. 9:72019. View Article : Google Scholar

43 

Zhou C, Zhang L and Xu P: Growth inhibition and chemo-radiosensitization of esophageal squamous cell carcinoma by survivin-shRNA lentivirus transfection. Oncol Lett. 16:4813–4820. 2018.PubMed/NCBI

44 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Shao W, Machamer CE and Espenshade PJ: Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. J Lipid Res. 57:1564–1573. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Pierrot N, Tyteca D, D'Auria L, Dewachter I, Gailly P, Hendrickx A, Tasiaux B, Haylani LE, Muls N, N'kuli F, et al: Amyloid precursor protein controls cholesterol turnover needed for neuronal activity. EMBO Mol Med. 5:608–625. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Guillet-Deniau I, Pichard AL, Koné A, Esnous C, Nieruchalski M, Girard J and Prip-Buus C: Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway. J Cell Sci. 117:1937–1944. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Koizume S, Takahashi T, Yoshihara M, Nakamura Y, Ruf W, Takenaka K, Miyagi E and Miyagi Y: Cholesterol starvation and hypoxia activate the FVII gene via the SREBP1-GILZ pathway in ovarian cancer cells to produce procoagulant microvesicles. Thromb Haemost. 119:1058–1071. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Lo AK, Lung RW, Dawson CW, Young LS, Ko CW, Yeung WW, Kang W, To KF and Lo KW: Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma. J Pathol. 246:180–190. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Perone Y, Farrugia AJ, Meira AR, Rodríguez-Meira A, Győrffy B, Ion C, Uggetti A, Chronopoulos A, Marrazzo P, Faronato M, et al: SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer. Nat Commun. 10:21152019. View Article : Google Scholar : PubMed/NCBI

51 

Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, et al: SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2. Cell Death Differ. 26:843–859. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, et al: Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 21:341–352. 2020. View Article : Google Scholar : PubMed/NCBI

53 

Gong F, Chen MF, Chen J, Li C, Zhou C, Hong P, Sun S and Qian ZJ: Boiled abalone byproduct peptide exhibits anti-tumor activity in HT1080 cells and HUVECs by suppressing the metastasis and angiogenesis in vitro. J Agric Food Chem. 67:8855–8867. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Motoyama K, Fukumoto S, Koyama H, Emoto M, Shimano H, Maemura K and Nishizawa Y: SREBP inhibits VEGF expression in human smooth muscle cells. Biochem Biophys Res Commun. 342:354–360. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Zhang L, Wang JH, Liang RX, Huang ST, Xu J, Yuan LJ, Huang L, Zhou Y, Yu XJ, Wu SY, et al: RASSF8 downregulation promotes lymphangiogenesis and metastasis in esophageal squamous cell carcinoma. Oncotarget. 6:34510–34524. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Liu G, Kuang S, Cao R, Wang J, Peng Q and Sun C: Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway. FASEB J. 33:10089–10103. 2019. View Article : Google Scholar : PubMed/NCBI

57 

Jain P, Nattakom M, Holowka D, Wang DH, Thomas Brenna J, Ku AT, Nguyen H, Ibrahim SF and Tumbar T: Runx1 role in epithelial and cancer cell proliferation implicates lipid metabolism and scd1 and soat1 Activity. Stem cells. 36:1603–1616. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Mancini R, Noto A, Pisanu ME, De Vitis C, Maugeri-Sacca M and Ciliberto G: Metabolic features of cancer stem cells: The emerging role of lipid metabolism. Oncogene. 37:2367–2378. 2018. View Article : Google Scholar : PubMed/NCBI

59 

El Helou R, Pinna G, Cabaud O, Wicinski J, Bhajun R, Guyon L, Rioualen C, Finetti P, Gros A, Mari B, et al: miR-600 acts as a bimodal switch that regulates breast cancer stem cell fate through WNT signaling. Cell Rep. 18:2256–2268. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Bruschini S, di Martino S, Pisanu ME, Fattore L, De Vitis C, Laquintana V, Buglioni S, Tabbì E, Cerri A, Visca P, et al: CytoMatrix for a reliable and simple characterization of lung cancer stem cells from malignant pleural effusions. J Cell Physiol. 235:1877–1887. 2020. View Article : Google Scholar : PubMed/NCBI

61 

Lim CH, Park YJ, Shin M, Cho YS, Choi JY, Lee KH and Hyun SH: Tumor SUVs on 18F-FDG PET/CT and aggressive pathological features in esophageal squamous cell carcinoma. Clin Nucl Med. 45:e128–e133. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Ling R, Zhou Y, Gao X, Yang Y, Mao C and Chen D: SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway. Oncol Lett 20: 2855-2869, 2020.
APA
Wang, J., Ling, R., Zhou, Y., Gao, X., Yang, Y., Mao, C., & Chen, D. (2020). SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway. Oncology Letters, 20, 2855-2869. https://doi.org/10.3892/ol.2020.11853
MLA
Wang, J., Ling, R., Zhou, Y., Gao, X., Yang, Y., Mao, C., Chen, D."SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway". Oncology Letters 20.3 (2020): 2855-2869.
Chicago
Wang, J., Ling, R., Zhou, Y., Gao, X., Yang, Y., Mao, C., Chen, D."SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway". Oncology Letters 20, no. 3 (2020): 2855-2869. https://doi.org/10.3892/ol.2020.11853
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Ling R, Zhou Y, Gao X, Yang Y, Mao C and Chen D: SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway. Oncol Lett 20: 2855-2869, 2020.
APA
Wang, J., Ling, R., Zhou, Y., Gao, X., Yang, Y., Mao, C., & Chen, D. (2020). SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway. Oncology Letters, 20, 2855-2869. https://doi.org/10.3892/ol.2020.11853
MLA
Wang, J., Ling, R., Zhou, Y., Gao, X., Yang, Y., Mao, C., Chen, D."SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway". Oncology Letters 20.3 (2020): 2855-2869.
Chicago
Wang, J., Ling, R., Zhou, Y., Gao, X., Yang, Y., Mao, C., Chen, D."SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway". Oncology Letters 20, no. 3 (2020): 2855-2869. https://doi.org/10.3892/ol.2020.11853
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