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Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer

  • Authors:
    • Hongyu Zhou
    • Xuan Zou
    • Haoran Li
    • Tianjiao Li
    • Lihua Chen
    • Xi Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 24
    |
    Published online on: July 16, 2020
       https://doi.org/10.3892/ol.2020.11885
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Abstract

Endometrial cancer is the most common malignancies in developed countries. The present study aimed to identify the role of secretoglobin family 2A member 1 (SCGB2A1) expression in uteri corpus endometrial carcinoma (UCEC) from The Cancer Genome Atlas (TCGA) database, and determine the SCGB2A1‑associated downstream signaling pathways. The clinicopathological characteristics and gene expression data were downloaded from TCGA database. The Kaplan‑Meier method and Cox multivariate model were used for survival analysis. Logistic regression was used to analyze the association between the clinicopathological features and SCGB2A1 expression. For validation, data of SCGB2A1 mRNA expression and protein expression were obtained and then survival analysis was performed for 47 patients with endometrial cancer from the Fudan University Shanghai Cancer Center (FUSCC). In TCGA dataset, SCGB2A1 expression was significantly higher in tumor tissues (n=528) compared with normal tissues (n=23, P<0.001). The decrease in SCGB2A1 expression in UCEC was significantly associated with age at diagnosis, high tumor grade, residual tumor, positive peritoneal cytology, pelvic lymph node metastasis, para‑aortic lymph node metastasis and advanced clinical stage with P<0.05. In the multivariate analysis, SCGB2A1 expression was identified as an independent prognostic factor. In the FUSCC validation set, low SCGB2A1 expression was also associated with worse survival compared with high expression in endometrial cancer (P<0.001). Gene Set Enrichment Analysis revealed that SCGB2A1 may be involved in tumor proliferation and cell cycle regulation. In conclusion, SCGB2A1 may have an important role in the prognosis of UCEC, and has value as a new target for novel therapeutic strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Zou X, Li H, Li T, Chen L and Cheng X: Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer. Oncol Lett 20: 24, 2020.
APA
Zhou, H., Zou, X., Li, H., Li, T., Chen, L., & Cheng, X. (2020). Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer. Oncology Letters, 20, 24. https://doi.org/10.3892/ol.2020.11885
MLA
Zhou, H., Zou, X., Li, H., Li, T., Chen, L., Cheng, X."Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer". Oncology Letters 20.4 (2020): 24.
Chicago
Zhou, H., Zou, X., Li, H., Li, T., Chen, L., Cheng, X."Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer". Oncology Letters 20, no. 4 (2020): 24. https://doi.org/10.3892/ol.2020.11885
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Zou X, Li H, Li T, Chen L and Cheng X: Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer. Oncol Lett 20: 24, 2020.
APA
Zhou, H., Zou, X., Li, H., Li, T., Chen, L., & Cheng, X. (2020). Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer. Oncology Letters, 20, 24. https://doi.org/10.3892/ol.2020.11885
MLA
Zhou, H., Zou, X., Li, H., Li, T., Chen, L., Cheng, X."Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer". Oncology Letters 20.4 (2020): 24.
Chicago
Zhou, H., Zou, X., Li, H., Li, T., Chen, L., Cheng, X."Decreased secretoglobin family 2A member 1expression is associated with poor outcomes in endometrial cancer". Oncology Letters 20, no. 4 (2020): 24. https://doi.org/10.3892/ol.2020.11885
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