Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)

  • Authors:
    • Zeeshan Javed
    • Khushbukhat Khan
    • Muhammad Zaheer Iqbal
    • Touqeer Ahmad
    • Qamar Raza
    • Haleema Sadia
    • Shahid Raza
    • Bahare Salehi
    • Javad Sharifi‑Rad
    • William C. Cho
  • View Affiliations / Copyright

    Affiliations: Office for Research Innovation and Commercialization, Lahore Garrison University, Lahore, Punjab 54792, Pakistan, Atta‑ur‑Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Punjab 44000, Pakistan, Center for Excellence in Molecular Biology, University of the Punjab, Lahore, Punjab 53700, Pakistan, Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Punjab 54000, Pakistan, Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Punjab 54000, Pakistan, Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Balochistan 87100, Pakistan, Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam 44340847, Iran, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran, Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, P.R. China
    Copyright: © Javed et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 37
    |
    Published online on: July 23, 2020
       https://doi.org/10.3892/ol.2020.11896
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer is a complex disease posing a serious threat to the female population worldwide. A complex molecular landscape and tumor heterogeneity render breast cancer cells resistant to drugs and able to promote metastasis and invasiveness. Despite the recent advancements in diagnostics and drug discovery, finding an effective cure for breast cancer is still a major challenge. Positive and negative regulation of apoptosis has been a subject of extensive study over the years. Numerous studies have shed light on the mechanisms that impede the tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) signaling cascade. Long non‑coding RNAs (lncRNAs) have been implicated in the orchestration, development, proliferation, differentiation and metastasis of breast cancer. However, the roles of lncRNAs in fine‑tuning apoptosis regulating machinery in breast cancer remain to be elucidated. The present review illuminates the roles of these molecules in the regulation of breast cancer and the interplay between lncRNA and TRAIL in breast cancer. The present review also attempts to reveal their role in the regulation of apoptosis in breast cancer appears a promising approach for the development of new diagnostic and therapeutic regimens.
View Figures

Figure 1

Figure 2

View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

3 

DeSantis CE, Fedewa SA, Goding Sauer A, Kramer JL, Smith RA and Jemal A: Breast cancer statistics, 2015: Convergence of incidence rates between black and white women. CA Cancer J Clin. 66:31–42. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Zur Hausen H, Bund T and de Villiers EM: Specific nutritional infections early in life as risk factors for human colon and breast cancers several decades later. Int J Cancer. 144:1574–1583. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Naoum GE, Buchsbaum DJ, Tawadros F, Farooqi A and Arafat WO: Journey of TRAIL from bench to bedside and its potential role in immuno-oncology. Oncol Rev. 11:3322017.PubMed/NCBI

6 

Johnstone RW, Frew AJ and Smyth MJ: The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer. 8:782–798. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Shi X, Li Y, Sun Y, Zhao X, Sun X, Gong T, Liang Z, Ma Y and Zhang X: Genome-wide analysis of lncRNAs, miRNAs, and mRNAs forming a prognostic scoring system in esophageal squamous cell carcinoma. PeerJ. 8:e83682020. View Article : Google Scholar : PubMed/NCBI

8 

Tirosh I and Suvà ML: Deciphering human tumor biology by single-cell expression profiling. Ann Rev Cancer Biol. 3:151–166. 2019. View Article : Google Scholar

9 

Farooqi AA, Mukhtar S, Riaz AM, Waseem S, Minhaj S, Dilawar BA, Malik BA, Nawaz A and Bhatti S: Wnt and SHH in prostate cancer: Trouble mongers occupy the TRAIL towards apoptosis. Cell Prolif. 44:508–515. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Walensky LD: Cheating death: New molecules block BAX. Trends Mol Med. 25:259–261. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Mazurek N, Byrd JC, Sun Y, Hafley M, Ramirez K, Burks J and Bresalier RS: Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells. Cell Death Differ. 19:523–533. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Seyrek K, Richter M and Lavrik IN: Decoding the sweet regulation of apoptosis: The role of glycosylation and galectins in apoptotic signaling pathways. Cell Death Differ. 26:981–993. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, et al: Regulation of death receptor signaling by the autophagy protein TP53INP2. EMBO J. 38:e993002019. View Article : Google Scholar : PubMed/NCBI

14 

Kaufmann T, Strasser A and Jost PJ: Fas death receptor signalling: Roles of Bid and XIAP. Cell Death Differ. 19:42–50. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, et al: TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL. EMBO J. 16:5386–5397. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Rahman M, Davis SR, Pumphrey JG, Bao J, Nau MM, Meltzer PS and Lipkowitz S: TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype. Br Cancer Res Treat. 113:217–230. 2009. View Article : Google Scholar

17 

Ahmad M and Shi Y: TRAIL-induced apoptosis of thyroid cancer cells: Potential for therapeutic intervention. Oncogene. 19:3363–3371. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Zhao L, Dong A, Gu J, Liu Z, Zhang Y, Zhang W, Wang Y, He L, Qian C, Qian Q and Liu X: The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer. Cancer Gene Ther. 13:1011–1022. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Brooks AD and Sayers TJ: Reduction of the antiapoptotic protein cFLIP enhances the susceptibility of human renal cancer cells to TRAIL apoptosis. Cancer Immunol Immunother. 54:499–505. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Voelkel-Johnson C: TRAIL-mediated signaling in prostate, bladder and renal cancer. Nat Rev Urol. 8:417–427. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Cuello M, Ettenberg SA, Nau MM and Lipkowitz S: Synergistic induction of apoptosis by the combination of trail and chemotherapy in chemoresistant ovarian cancer cells. Gynecol Oncol. 81:380–390. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Finnberg NK and El-Deiry WS: TRAIL death receptors as tumor suppressors and drug targets. Cell Cycle. 7:1525–1528. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Zhang Y and Zhang B: TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5. Mol Cancer Res. 6:1861–1871. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Tollefson AE, Toth K, Doronin K, Kuppuswamy M, Doronina OA, Lichtenstein DL, Hermiston TW, Smith CA and Wold WS: Inhibition of TRAIL-induced apoptosis and forced internalization of TRAIL receptor 1 by adenovirus proteins. J Virol. 75:8875–8887. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Suliman A, Lam A, Datta R and Srivastava RK: Intracellular mechanisms of TRAIL: Apoptosis through mitochondrial-dependent and-independent pathways. Oncogene. 20:2122–2133. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Screaton RA, Kiessling S, Sansom OJ, Millar CB, Maddison K, Bird A, Clarke AR and Frisch SM: Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis. Proc Natl Acad Sci USA. 100:5211–5216. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Aggarwal BB, Bhardwaj U and Takada Y: Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors. Vitamins & Hormones Elsevier. 453–483. 2004. View Article : Google Scholar

28 

Jang CW, Chen CH, Chen CC, Chen JY, Su YH and Chen RH: TGF-Beta induces apoptosis through Smad-mediated expression of DAP-kinase. Nat Cell Biol. 4:51–58. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Kruidering M and Evan GI: Caspase-8 in apoptosis: The beginning of ‘the end’? IUBMB Life. 50:85–90. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Farooqi AA and De Rosa G: TRAIL and microRNAs in the treatment of prostate cancer: Therapeutic potential and role of nanotechnology. Appl Microbiol Biotechnol. 97:8849–8857. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Falschlehner C, Emmerich CH, Gerlach B and Walczak H: TRAIL signalling: Decisions between life and death. Int J Biochem Cell Biol. 39:1462–1475. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Han Li C and Chen Y: Small and long non-coding RNAs: Novel targets in perspective cancer therapy. Curr Genomics. 16:319–326. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Müller V, Oliveira-Ferrer L, Steinbach B, Pantel K and Schwarzenbach H: Interplay of lncRNA H19/miR-675 and lncRNA NEAT1/miR-204 in breast cancer. Mol Oncol. 13:1137–1149. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Javed Z, Ahmed Shah F, Rajabi S, Raza Q, Iqbal Z, Ullah M, Ahmad T, Salehi B, Sharifi-Rad M, Pezzani R, et al: LncRNAs as potential therapeutic targets in thyroid cancer. Asian Pac J Cancer Prev. 21:281–287. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Wang A, Bao Y, Wu Z, Zhao T, Wang D, Shi J, Liu B, Sun S, Yang F, Wang L and Qu L: Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer. Cell Death Dis. 10:1542019. View Article : Google Scholar : PubMed/NCBI

36 

Luo H, Xu C, Le W, Ge B and Wang T: lncRNA CASC11 promotes cancer cell proliferation in bladder cancer through miRNA-150. J Cell Biochem. 120:13487–13493. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Luo J, Wang K, Yeh S, Sun Y, Liang L, Xiao Y, Xu W, Niu Y, Cheng L, Maity SN, et al: LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling. Nat Commun. 10:25712019. View Article : Google Scholar : PubMed/NCBI

38 

Zhang Y and Ruan F: LncRNA LEF1-AS1 promotes ovarian cancer development through interacting with miR-1285-3p. Cancer Manag Res. 12:687–694. 2020. View Article : Google Scholar : PubMed/NCBI

39 

He RZ, Luo DX and Mo YY: Emerging roles of lncRNAs in the post-transcriptional regulation in cancer. Genes Dis. 6:62019. View Article : Google Scholar : PubMed/NCBI

40 

Lau E: Non-coding RNA: Zooming in on lncRNA functions. Nat Rev Genet. 15:574–575. 2014. View Article : Google Scholar : PubMed/NCBI

41 

van Leeuwen S and Mikkers H: Long non-coding RNAs: Guardians of development. Differentiation. 80:175–183. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Ye N, Wang B, Quan ZF, Cao SJ, Wen XT, Huang Y, Huang XB, Wu R, Ma XP, Yan QG, et al: Functional roles of long non-coding RNA in human breast cancer. Asian Pac J Cancer Prev. 15:5993–5997. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, Barrette TR, Prensner JR, Evans JR, Zhao S, et al: The landscape of long noncoding RNAs in the human transcriptome. Nat Genet. 47:199–208. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Cheetham S, Gruhl F, Mattick J and Dinger M: Long noncoding RNAs and the genetics of cancer. Br J Cancer. 108:2419–2425. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Lee JT and Bartolomei MS: X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell. 152:1308–1323. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Zhang TH, Liang LZ, Liu XL, Wu JN, Su K, Chen JY and Zheng QY: LncRNA UCA1/miR-124 axis modulates TGFβ1-induced epithelial-mesenchymal transition and invasion of tongue cancer cells through JAG1/Notch signaling. J Cell Biochem. 120:10495–10504. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Kawakami T, Zhang C, Taniguchi T, Kim CJ, Okada Y, Sugihara H, Hattori T, Reeve AE, Ogawa O and Okamoto K: Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells. Oncogene. 23:6163–6169. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Postlmayr A and Wutz A: Insights into the establishment of chromatin states in pluripotent cells from studies of X inactivation. J Mol Biol. 429:1521–1531. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Li X, Hou L, Yin L and Zhao S: LncRNA XIST interacts with miR-454 to inhibit cells proliferation, epithelial mesenchymal transition and induces apoptosis in triple-negative breast cancer. J Biosci. 45:452020. View Article : Google Scholar : PubMed/NCBI

50 

Zheng R, Lin S, Guan L, Yuan H, Liu K, Liu C, Ye W, Liao Y, Jia J and Zhang R: Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochem Biophys Res Commun. 498:1002–1008. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Zhao L, Zhao Y, He Y, Li Q and Mao Y: The functional pathway analysis and clinical significance of miR-20a and its related lncRNAs in breast cancer. Cell Signal. 51:152–165. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Chen Y and Li CH: Novel therapeutic targets for hepatocellular carcinoma treatment. Hepatocellular Carcinoma Basic Res. 352012.doi: 10.5772/28894.

54 

Battistelli C, Sabarese G, Santangelo L, Montaldo C, Gonzalez FJ, Tripodi M and Cicchini C: The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation. Cell Death Differ. 26:890–901. 2019. View Article : Google Scholar : PubMed/NCBI

55 

Qu X, Alsager S, Zhuo Y and Shan B: HOX transcript antisense RNA (HOTAIR) in cancer. Cancer Lett. 454:90–97. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Bhan A and Mandal SS: LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer. Biochim Biophys Acta. 1856:151–164. 2015.PubMed/NCBI

57 

Cai B, Song X, Cai J and Zhang S: HOTAIR: A cancer-related long non-coding RNA. Neoplasma. 61:379–391. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F and Zheng SS: Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 18:1243–1250. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Hajjari M and Salavaty A: HOTAIR: An oncogenic long non-coding RNA in different cancers. Cancer Bio Med. 12:1–9. 2015.

60 

Bhan A, Hussain I, Ansari KI, Kasiri S, Bashyal A and Mandal SS: Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol Biol. 425:3707–3722. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Amândio AR, Necsulea A, Joye E, Mascrez B and Duboule D: Hotair is dispensible for mouse development. PLoS Genet. 12:e10062322016. View Article : Google Scholar : PubMed/NCBI

62 

Sørensen KP, Thomassen M, Tan Q, Bak M, Cold S, Burton M, Larsen MJ and Kruse TA: Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer. Breast cancer Res Treat. 142:529–536. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Tao S, He H and Chen Q: Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer. J Transl Med. 13:1312015. View Article : Google Scholar : PubMed/NCBI

64 

Lv R, Zhang J, Zhang W, Huang Y, Wang N, Zhang Q and Qu S: Circulating HOTAIR expression predicts the clinical response to neoadjuvant chemotherapy in patients with breast cancer. Cancer Biomark. 22:249–256. 2018. View Article : Google Scholar : PubMed/NCBI

65 

Zhang M, Wu WB, Wang ZW and Wang XH: lncRNA NEAT1 is closely related with progression of breast cancer via promoting proliferation and EMT. Eur Rev Med Pharmacol Sci. 21:1020–1026. 2017.PubMed/NCBI

66 

Li W, Zhang Z, Liu X, Cheng X, Zhang Y, Han X, Zhang Y, Liu S, Yang J, Xu B, et al: The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. J Clin Invest. 127:3421–3440. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Shin VY, Chen J, Cheuk IW, Siu MT, Ho CW, Wang X, Jin H and Kwong A: Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness. Cell Death Dis. 10:2702019. View Article : Google Scholar : PubMed/NCBI

68 

Qian K, Liu G, Tang Z, Hu Y, Fang Y, Chen Z and Xu X: The long non-coding RNA NEAT1 interacted with miR-101 modulates breast cancer growth by targeting EZH2. Arch Biochem Biophys. 615:1–9. 2017. View Article : Google Scholar : PubMed/NCBI

69 

Li X, Wang S, Li Z, Long X, Guo Z, Zhang G, Zu J, Chen Y and Wen L: The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211/HMGA2 axis in breast cancer. Int J Biol Macromol. 105:346–353. 2017. View Article : Google Scholar : PubMed/NCBI

70 

Ke H, Zhao L, Feng X, Xu H, Zou L, Yang Q, Su X, Peng L and Jiao B: NEAT1 is required for survival of breast cancer cells through FUS and miR-548. Gene Regul Syst Bio. 10 (Suppl 1):S11–S17. 2016.

71 

Godinho M, Meijer D, Setyono-Han B, Dorssers LC and van Agthoven T: Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells. J Cell Physiol. 226:1741–1749. 2011. View Article : Google Scholar : PubMed/NCBI

72 

Godinho MF, Wulfkuhle JD, Look MP, Sieuwerts AM, Sleijfer S, Foekens JA, Petricoin EF III, Dorssers LC and van Agthoven T: BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib. Br J Cancer. 107:947–955. 2012. View Article : Google Scholar : PubMed/NCBI

73 

Xing Z, Park PK, Lin C and Yang L: LncRNA BCAR4 wires up signaling transduction in breast cancer. RNA Biol. 12:681–689. 2015. View Article : Google Scholar : PubMed/NCBI

74 

Sun Q, Hao Q and Prasanth KV: Nuclear long noncoding RNAs: Key regulators of gene expression. Trends Genet. 34:142–157. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Godinho MF, Sieuwerts AM, Look MP, Meijer D, Foekens JA, Dorssers LC and van Agthoven T: Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer. Br J Cancer. 103:1284–1291. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Niknafs YS, Han S, Ma T, Speers C, Zhang C, Wilder-Romans K, Iyer MK, Pitchiaya S, Malik R, Hosono Y, et al: The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Nat Commun. 7:127912016. View Article : Google Scholar : PubMed/NCBI

77 

Wang Z and Zöller M: Exosomes, metastases, and the miracle of cancer stem cell markers. Cancer Metastasis Rev. 38:259–295. 2019. View Article : Google Scholar : PubMed/NCBI

78 

Ouyang D, Su J, Huang P, Li M, Li Q, Zhao P, Chen Q, Zou Q, Feng X, Qian K, et al: Identification of lncRNAs via microarray analysis for predicting HER2-negative breast cancer response to neoadjuvant chemotherapy. Int J Clin Exp Pathol. 11:2621–2628. 2018.PubMed/NCBI

79 

Chen YK and Yen Y: The ambivalent role of lncRNA Xist in carcinogenesis. Stem Cell Rev Rep. 15:314–323. 2019. View Article : Google Scholar : PubMed/NCBI

80 

Mazor G, Levin L, Picard D, Ahmadov U, Carén H, Borkhardt A, Reifenberger G, Leprivier G, Remke M and Rotblat B: The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Cell Death Dis. 10:2462019. View Article : Google Scholar : PubMed/NCBI

81 

Wang Y, Yang L, Chen T, Liu X, Guo Y, Zhu Q, Tong X, Yang W, Xu Q, Huang D and Tu K: A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis. Mol Cancer. 18:282019. View Article : Google Scholar : PubMed/NCBI

82 

Kang CL, Qi B, Cai QQ, Fu LS, Yang Y, Tang C, Zhu P, Chen QW, Pan J, Chen MH and Wu XZ: LncRNA AY promotes hepatocellular carcinoma metastasis by stimulating ITGAV transcription. Theranostics. 9:4421–4436. 2019. View Article : Google Scholar : PubMed/NCBI

83 

Zhang H, Zhu M, Du Y, Zhang H, Zhang Q, Liu Q, Huang Z, Zhang L, Li H, Xu L, et al: A panel of 12-lncRNA signature predicts survival of pancreatic adenocarcinoma. J Cancer. 10:1550–1559. 2019. View Article : Google Scholar : PubMed/NCBI

84 

Yang G, Lu X and Yuan L: LncRNA: A link between RNA and cancer. Biochim Biophys Acta. 1839:1097–1109. 2014. View Article : Google Scholar : PubMed/NCBI

85 

Farooqi AA, Attar R, Qureshi MZ, Fayyaz S, Sohail MI, Sabitaliyevich UY, Nurmurzayevich SB, Yelekenova A, Yaylim I and Alaaeddine N: Interplay of long non-coding RNAs and TGF/SMAD signaling in different cancers. Cell Mol Biol (Noisy-le-Grand). 64:1–6. 2018. View Article : Google Scholar : PubMed/NCBI

86 

Jiang Y, Lin L, Zhong S, Cai Y, Zhang F, Wang X, Miao R, Zhang B, Gao S and Hu X: Overexpression of novel lncRNA NLIPMT inhibits metastasis by reducing phosphorylated glycogen synthase kinase 3β in breast cancer. J Cell Physiol. 234:10698–10708. 2019. View Article : Google Scholar : PubMed/NCBI

87 

Liu Y, Sharma S and Watabe K: Roles of lncRNA in breast cancer. Front Biosci (Schol Ed). 7:94–108. 2015. View Article : Google Scholar : PubMed/NCBI

88 

Guan Y, Bhandari A, Xia E, Yang F, Xiang J and Wang O: lncRNA FOXD3-AS1 is associated with clinical progression and regulates cell migration and invasion in breast cancer. Cell Biochem Funct. 37:239–244. 2019. View Article : Google Scholar : PubMed/NCBI

89 

Liu AN, Qu HJ, Gong WJ, Xiang JY, Yang MM and Zhang W: LncRNA AWPPH and miRNA-21 regulates cancer cell proliferation and chemosensitivity in triple-negative breast cancer by interacting with each other. J Cell Biochem. 120:14860–14866. 2019. View Article : Google Scholar : PubMed/NCBI

90 

Shi SJ, Wang LJ, Yu B, Li YH, Jin Y and Bai XZ: LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer. Oncotarget. 6:11652–11663. 2015. View Article : Google Scholar : PubMed/NCBI

91 

Augoff K, McCue B, Plow EF and Sossey-Alaoui K: miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol Cancer. 11:52012. View Article : Google Scholar : PubMed/NCBI

92 

Li Z, Hou P, Fan D, Dong M, Ma M, Li H, Yao R, Li Y, Wang G, Geng P, et al: The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer. Cell Death Differ. 24:59–71. 2017. View Article : Google Scholar : PubMed/NCBI

93 

Guo R, Su Y, Xue J, Si J, Chi Y and Wu J: Abstract P6-05-01: A novel cleaved cytoplasmic lncRNA LacRNA interacts with PHB2 and suppresses breast cancer metastasis via repressing MYC targets. Cancer Res. 792019.doi: 10.1158/1538-7445. PubMed/NCBI

94 

Li W, Jia G, Qu Y, Du Q and Liu B and Liu B: Long non-coding RNA (LncRNA) HOXA11-AS promotes breast cancer invasion and metastasis by regulating epithelial-mesenchymal transition. Med Sci Monit. 23:3393–3403. 2017. View Article : Google Scholar : PubMed/NCBI

95 

Li Z, Dong M, Fan D, Hou P, Li H, Liu L, Lin C, Liu J, Su L, Wu L, et al: LncRNA ANCR down-regulation promotes TGF-β-induced EMT and metastasis in breast cancer. Oncotarget. 8:67329–67343. 2017. View Article : Google Scholar : PubMed/NCBI

96 

Naval J, de Miguel D, Gallego-Lleyda A, Anel A and Martinez-Lostao L: Importance of TRAIL molecular anatomy in receptor oligomerization and signaling. Implications for Cancer Therapy. Cancers (Basel). 11:4442019. View Article : Google Scholar

97 

Mert U and Sanlioglu AD: Intracellular localization of DR5 and related regulatory pathways as a mechanism of resistance to TRAIL in cancer. Cell Mol Life Sci. 74:245–255. 2017. View Article : Google Scholar : PubMed/NCBI

98 

Li T, Liu Y, Xiao H and Xu G: Long non-coding RNA TUG1 promotes cell proliferation and metastasis in human breast cancer. Breast Cancer. 24:535–543. 2017. View Article : Google Scholar : PubMed/NCBI

99 

Yang J, Meng X, Yu Y, Pan L, Zheng Q and Lin W: LncRNA POU3F3 promotes proliferation and inhibits apoptosis of cancer cells in triple-negative breast cancer by inactivating caspase 9. Biosci Biotechnol Biochem. 83:1117–1123. 2019. View Article : Google Scholar : PubMed/NCBI

100 

Shan TD, Xu JH, Yu T, Li JY, Zhao LN, Ouyang H, Luo S, Lu XJ, Huang CZ, Lan QS, et al: Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer. Oncotarget. 7:961–975. 2016. View Article : Google Scholar : PubMed/NCBI

101 

Rossi MN and Antonangeli F: LncRNAs: New players in apoptosis control. Int J Cell Biol. 2014:4738572014. View Article : Google Scholar : PubMed/NCBI

102 

Qu Y, Wang Y, Wang P, Lin N, Yan X and Li Y: Overexpression of long noncoding RNA HOXA-AS2 predicts an adverse prognosis and promotes tumorigenesis via SOX4/PI3K/AKT pathway in acute myeloid leukemia. Cell Biol Int. May 5–2020.doi: 10.1002/cbin.11370 (Epub ahead of print). View Article : Google Scholar

103 

Awasthee N, Rai V, Verma SS, Francis KS, Nair MS and Gupta SC: Anti-cancer activities of Bharangin against breast cancer: Evidence for the role of NF-κB and lncRNAs. Biochim Biophys Acta Gen Subj. 1862:2738–2749. 2018. View Article : Google Scholar : PubMed/NCBI

104 

Dianatpour A, Faramarzi S, Geranpayeh L, Mirfakhraie R, Motevaseli E and Ghafouri-Fard S: Expression analysis of AFAP1-AS1 and AFAP1 in breast cancer. Cancer Biomark. 22:49–54. 2018. View Article : Google Scholar : PubMed/NCBI

105 

Zhang H and Lu B: microRNAs as biomarkers of ovarian cancer. Expert Rev Anticancer Ther. 20:373–385. 2020. View Article : Google Scholar : PubMed/NCBI

106 

Huang YS, Chang CC, Lee SS, Jou YS and Shih HM: Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression. Oncotarget. 7:432562016. View Article : Google Scholar : PubMed/NCBI

107 

Gooding AJ, Zhang B, Jahanbani FK, Gilmore HL, Chang JC, Valadkhan S and Schiemann WP: The lncRNA BORG drives breast cancer metastasis and disease recurrence. Sci Rep. 7:126982017. View Article : Google Scholar : PubMed/NCBI

108 

Gooding AJ, Zhang B, Gunawardane L, Beard A, Valadkhan S and Schiemann WP: The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers. Oncogene. 38:20202019. View Article : Google Scholar : PubMed/NCBI

109 

Deng R, Liu B, Wang Y, Yan F, Hu S, Wang H, Wang T, Li B, Deng X, Xiang S, Yang Y and Zhang J: High expression of the newly found long noncoding RNA Z38 promotes cell proliferation and oncogenic activity in breast cancer. J Cancer. 7:576–578. 2016. View Article : Google Scholar : PubMed/NCBI

110 

Wang Y, Zheng C, Li T, Zhang R, Wang Y, Zhang J, He Q, Sun Z and Wang X: Long noncoding RNA Z38 promotes cell proliferation and metastasis and inhibits cell apoptosis in human gastric cancer. Oncolo Lett. 16:6051–6058. 2018.

111 

Nie ZL, Wang YS, Mei YP, Lin X, Zhang GX, Sun HL, Wang YL, Xia YX and Wang SK: Prognostic significance of long noncoding RNA Z38 as a candidate biomarker in breast cancer. J Clin Lab Anal. 32:e221932018. View Article : Google Scholar

112 

Zhang F, Li J, Xiao H, Zou Y, Liu Y and Huang W: AFAP1-AS1: A novel oncogenic long non-coding RNA in human cancers. Cell Proliferation. 51:e123972018. View Article : Google Scholar

113 

Ma D, Chen C, Wu J, Wang H and Wu D: Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis and promotes carcinogenesis of breast cancer. Breast Cancer. 26:74–83. 2019. View Article : Google Scholar : PubMed/NCBI

114 

Fan S, Yang Z, Ke Z, Huang K, Liu N, Fang X and Wang K: Downregulation of the long non-coding RNA TUG1 is associated with cell proliferation, migration, and invasion in breast cancer. Biomed Pharmacother. 95:1636–1643. 2017. View Article : Google Scholar : PubMed/NCBI

115 

Tang T, Cheng Y, She Q, Jiang Y, Chen Y, Yang W and Li Y: Long non-coding RNA TUG1 sponges miR-197 to enhance cisplatin sensitivity in triple negative breast cancer. Biomed Pharmacother. 107:338–346. 2018. View Article : Google Scholar : PubMed/NCBI

116 

Ghavami S, Hashemi M, Ande SR, Yeganeh B, Xiao W, Eshraghi M, Bus CJ, Kadkhoda K, Wiechec E, Halayko AJ and Los M: Apoptosis and cancer: Mutations within caspase genes. J Med Genet. 46:497–510. 2009. View Article : Google Scholar : PubMed/NCBI

117 

Rossin A, Miloro G and Hueber AO: TRAIL and FasL functions in cancer and autoimmune diseases: Towards an increasing complexity. Cancers. 11:6392019. View Article : Google Scholar

118 

Eberle J: Countering TRAIL resistance in melanoma. Cancers. 11:6562019. View Article : Google Scholar

119 

Kolben T, Jeschke U, Reimer T, Karsten N, Schmoeckel E, Semmlinger A, Mahner S, Harbeck N and Kolben TM: Induction of apoptosis in breast cancer cells in vitro by Fas ligand reverse signaling. J Cancer Res Clin Oncol. 144:249–256. 2018. View Article : Google Scholar : PubMed/NCBI

120 

Yang Y, Yang H, Xu M, Zhang H, Sun M, Mu P, Dong T, Du S and Liu K: Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway. Hum Cell. 31:232–241. 2018. View Article : Google Scholar : PubMed/NCBI

121 

Si X, Zang R, Zhang E, Liu Y, Shi X, Zhang E, Shao L, Li A, Yang N, Han X, et al: LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK. Oncotarget. 7:81452–81462. 2016. View Article : Google Scholar : PubMed/NCBI

122 

Sun H, Wang G, Peng Y, Zeng Y, Zhu QN, Li TL, Cai JQ, Zhou HH and Zhu YS: H19 lncRNA mediates 17β-estradiol-induced cell proliferation in MCF-7 breast cancer cells. Oncol Rep. 33:3045–3052. 2015. View Article : Google Scholar : PubMed/NCBI

123 

Zhang K, Luo Z, Zhang Y, Zhang L, Wu L, Liu L, Yang J, Song X and Liu J: Circulating lncRNA H19 in plasma as a novel biomarker for breast cancer. Cancer Biomark. 17:187–194. 2016. View Article : Google Scholar : PubMed/NCBI

124 

Lin Y and Tao H: Diagnostic value of plasma exosomal lncRNA H19 for breast cancer. Chin J Clin Laboratory Sci. 36:99–101. 2018.

125 

Han J, Han B, Wu X, Hao J, Dong X, Shen Q and Pang H: Knockdown of lncRNA H19 restores chemo-sensitivity in paclitaxel-resistant triple-negative breast cancer through triggering apoptosis and regulating Akt signaling pathway. Toxicol Appl Pharmacol. 359:55–61. 2018. View Article : Google Scholar : PubMed/NCBI

126 

Li J, Tian H, Yang J and Gong Z: Long noncoding RNAs regulate cell growth, proliferation, and apoptosis. DNA Cell Biol. 35:459–470. 2016. View Article : Google Scholar : PubMed/NCBI

127 

Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, et al: Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 43:621–629. 2011. View Article : Google Scholar : PubMed/NCBI

128 

Zhang A, Xu M and Mo YY: Role of the lncRNA-p53 regulatory network in cancer. J Mol Cell Biol. 6:181–191. 2014. View Article : Google Scholar : PubMed/NCBI

129 

Pickard MR and Williams GT: The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells. Oncotarget. 7:101042016. View Article : Google Scholar : PubMed/NCBI

130 

Zong Y, Zhang Y, Sun X, Xu T, Cheng X and Qin Y: miR-221/222 promote tumor growth and suppress apoptosis by targeting lncRNA GAS5 in breast cancer. Biosci Rep. 39:BSR201818592019. View Article : Google Scholar : PubMed/NCBI

131 

Zhang Z, Zhu Z, Watabe K, Zhang X, Bai C, Xu M, Wu F and Mo YY: Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ. 20:1558–1568. 2013. View Article : Google Scholar : PubMed/NCBI

132 

Wickramasinghe NS, Manavalan TT, Dougherty SM, Riggs KA, Li Y and Klinge CM: Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Res. 37:2584–2595. 2009. View Article : Google Scholar : PubMed/NCBI

133 

He X, Chen X, Zhang X, Duan X, Pan T, Hu Q, Zhang Y, Zhong F, Liu J, Zhang H, et al: An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes. Nucleic Acids Res. 43:3712–3725. 2015. View Article : Google Scholar : PubMed/NCBI

134 

Wang Y, Chu J, Yi P, Dong W, Saultz J, Wang Y, Wang H, Scoville S, Zhang J, Wu LC, et al: SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity. J Clin Invest. 128:5123–5136. 2018. View Article : Google Scholar : PubMed/NCBI

135 

Cano-González A and López-Rivas A: Opposing roles of TGF-β and EGF in the regulation of TRAIL-induced apoptosis in human breast epithelial cells. Biochim Biophys Acta. 1863:2104–2114. 2016. View Article : Google Scholar : PubMed/NCBI

136 

Hou L, Tu J, Cheng F, Yang H, Yu F, Wang M, Liu J, Fan J and Zhou G: Long noncoding RNA ROR promotes breast cancer by regulating the TGF-β pathway. Cancer Cell Int. 18:1422018. View Article : Google Scholar : PubMed/NCBI

137 

Zhang Y, Zhu M, Sun Y, Li W, Wang Y and Yu W: Upregulation of lncRNA CASC2 suppresses cell proliferation and metastasis of breast cancer via inactivation of the TGF-β signaling pathway. Oncol Res. 27:379–387. 2019. View Article : Google Scholar : PubMed/NCBI

138 

Batlle E and Massagué J: Transforming growth factor-β signaling in immunity and cancer. Immunity. 50:924–940. 2019. View Article : Google Scholar : PubMed/NCBI

139 

Arase M, Horiguchi K, Ehata S, Morikawa M, Tsutsumi S, Aburatani H, Miyazono K and Koinuma D: Transforming growth factor-β-induced lnc RNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells. Cancer Sci. 105:974–982. 2014. View Article : Google Scholar : PubMed/NCBI

140 

Hoshino Y, Katsuno Y, Ehata S and Miyazono K: Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim. J Biochem. 149:55–65. 2011. View Article : Google Scholar : PubMed/NCBI

141 

Xu ST, Xu JH, Zheng ZR, Zhao QQ, Zeng XS, Cheng SX, Liang YH and Hu QF: Long non-coding RNA ANRIL promotes carcinogenesis via sponging miR-199a in triple-negative breast cancer. Biomed Pharmacother. 96:14–21. 2017. View Article : Google Scholar : PubMed/NCBI

142 

Zhao JJ, Hao S, Wang LL, Hu CY, Zhang S, Guo LJ, Zhang G, Gao B, Jiang Y, Tian WG and Luo DL: Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-β/Smad signaling pathway. Oncotarget. 7:57903–57918. 2016. View Article : Google Scholar : PubMed/NCBI

143 

Chen J, Shin VY, Siu MT, Ho JC, Cheuk I and Kwong A: miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer. BMC Cancer. 16:8872016. View Article : Google Scholar : PubMed/NCBI

144 

Zhang Y, Fan KJ, Sun Q, Chen AZ, Shen WL, Zhao ZH, Zheng XF and Yang X: Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway. Nucleic Acids Res. 40:9286–9297. 2012. View Article : Google Scholar : PubMed/NCBI

145 

Wang J, Su Z, Lu S, Fu W, Liu Z, Jiang X and Tai S: LncRNA HOXA-AS2 and its molecular mechanisms in human cancer. Clin Chim Acta. 485:229–233. 2018. View Article : Google Scholar : PubMed/NCBI

146 

Fang Y, Wang J, Wu F, Song Y, Zhao S and Zhang Q: Long non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge. Oncotarget. 8:460902017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Javed Z, Khan K, Iqbal MZ, Ahmad T, Raza Q, Sadia H, Raza S, Salehi B, Sharifi‑Rad J, Cho WC, Cho WC, et al: Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review). Oncol Lett 20: 37, 2020.
APA
Javed, Z., Khan, K., Iqbal, M.Z., Ahmad, T., Raza, Q., Sadia, H. ... Cho, W.C. (2020). Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review). Oncology Letters, 20, 37. https://doi.org/10.3892/ol.2020.11896
MLA
Javed, Z., Khan, K., Iqbal, M. Z., Ahmad, T., Raza, Q., Sadia, H., Raza, S., Salehi, B., Sharifi‑Rad, J., Cho, W. C."Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)". Oncology Letters 20.4 (2020): 37.
Chicago
Javed, Z., Khan, K., Iqbal, M. Z., Ahmad, T., Raza, Q., Sadia, H., Raza, S., Salehi, B., Sharifi‑Rad, J., Cho, W. C."Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)". Oncology Letters 20, no. 4 (2020): 37. https://doi.org/10.3892/ol.2020.11896
Copy and paste a formatted citation
x
Spandidos Publications style
Javed Z, Khan K, Iqbal MZ, Ahmad T, Raza Q, Sadia H, Raza S, Salehi B, Sharifi‑Rad J, Cho WC, Cho WC, et al: Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review). Oncol Lett 20: 37, 2020.
APA
Javed, Z., Khan, K., Iqbal, M.Z., Ahmad, T., Raza, Q., Sadia, H. ... Cho, W.C. (2020). Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review). Oncology Letters, 20, 37. https://doi.org/10.3892/ol.2020.11896
MLA
Javed, Z., Khan, K., Iqbal, M. Z., Ahmad, T., Raza, Q., Sadia, H., Raza, S., Salehi, B., Sharifi‑Rad, J., Cho, W. C."Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)". Oncology Letters 20.4 (2020): 37.
Chicago
Javed, Z., Khan, K., Iqbal, M. Z., Ahmad, T., Raza, Q., Sadia, H., Raza, S., Salehi, B., Sharifi‑Rad, J., Cho, W. C."Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)". Oncology Letters 20, no. 4 (2020): 37. https://doi.org/10.3892/ol.2020.11896
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team