Open Access

Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)

  • Authors:
    • Zeeshan Javed
    • Khushbukhat Khan
    • Muhammad Zaheer Iqbal
    • Touqeer Ahmad
    • Qamar Raza
    • Haleema Sadia
    • Shahid Raza
    • Bahare Salehi
    • Javad Sharifi‑Rad
    • William C. Cho
  • View Affiliations

  • Published online on: July 23, 2020     https://doi.org/10.3892/ol.2020.11896
  • Article Number: 37
  • Copyright: © Javed et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is a complex disease posing a serious threat to the female population worldwide. A complex molecular landscape and tumor heterogeneity render breast cancer cells resistant to drugs and able to promote metastasis and invasiveness. Despite the recent advancements in diagnostics and drug discovery, finding an effective cure for breast cancer is still a major challenge. Positive and negative regulation of apoptosis has been a subject of extensive study over the years. Numerous studies have shed light on the mechanisms that impede the tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) signaling cascade. Long non‑coding RNAs (lncRNAs) have been implicated in the orchestration, development, proliferation, differentiation and metastasis of breast cancer. However, the roles of lncRNAs in fine‑tuning apoptosis regulating machinery in breast cancer remain to be elucidated. The present review illuminates the roles of these molecules in the regulation of breast cancer and the interplay between lncRNA and TRAIL in breast cancer. The present review also attempts to reveal their role in the regulation of apoptosis in breast cancer appears a promising approach for the development of new diagnostic and therapeutic regimens.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Javed Z, Khan K, Iqbal MZ, Ahmad T, Raza Q, Sadia H, Raza S, Salehi B, Sharifi‑Rad J, Cho WC, Cho WC, et al: Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review). Oncol Lett 20: 37, 2020
APA
Javed, Z., Khan, K., Iqbal, M.Z., Ahmad, T., Raza, Q., Sadia, H. ... Cho, W.C. (2020). Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review). Oncology Letters, 20, 37. https://doi.org/10.3892/ol.2020.11896
MLA
Javed, Z., Khan, K., Iqbal, M. Z., Ahmad, T., Raza, Q., Sadia, H., Raza, S., Salehi, B., Sharifi‑Rad, J., Cho, W. C."Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)". Oncology Letters 20.4 (2020): 37.
Chicago
Javed, Z., Khan, K., Iqbal, M. Z., Ahmad, T., Raza, Q., Sadia, H., Raza, S., Salehi, B., Sharifi‑Rad, J., Cho, W. C."Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review)". Oncology Letters 20, no. 4 (2020): 37. https://doi.org/10.3892/ol.2020.11896