Open Access

Inhibition of invadopodia formation by diosgenin in tumor cells (Review)

  • Authors:
    • Yaxin Lian
    • Dezhong Wen
    • Xiaoting Meng
    • Xiaozhen Wang
    • Hongcheng Li
    • Liming Hao
    • Hui Xue
    • Jia Zhao
  • View Affiliations

  • Published online on: September 23, 2020     https://doi.org/10.3892/ol.2020.12148
  • Article Number: 283
  • Copyright: © Lian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diosgenin is a type of steroid extracted from the rhizome of Dioscorea plants. In traditional Chinese medicine, Dioscorea has the effect of ‘eliminating phlegm, promoting digestion, relaxing tendons, promoting blood circulation and inhibiting malaria’. Recent studies have confirmed that diosgenin exhibits a number of pharmacological effects, including antitumor activities. Through its antitumor effect, diosgenin is able to block tumor progression and increase the survival rate of patients with cancer; ultimately improving their quality of life. However, the mechanism underlying its pharmacological action remains unclear. Once tumor cells reach a metastatic phase, it can be fatal. Increased migration and invasiveness are the hallmarks of metastatic tumor cells. Invadopodia formation is key to maintaining the high migration and invasive ability of tumor cells. Invadopodia are a type of membrane structure process rich in filamentous‑actin and are common in highly invasive tumor cells. In addition to actin, numerous actin regulators, including cortical actin‑binding protein (Cortactin), accumulate in invadopodia. Cortactin is a microfilament actin‑binding protein with special repetitive domains that are directly involved in the formation of the cortical microfilament actin cell skeleton. Cortactin is also one of the main substrates of intracellular Src‑type tyrosine protein kinases and represents a highly conserved family of intracellular cortical signaling proteins. In recent years, great progress has been made in understanding the role of Cortactin and its molecular mechanism in cell motility. However, the diosgenin‑Cortactin‑invadopodia mechanism is still under investigation. Therefore, the present review focused on the current research on the regulation of invadopodia by diosgenin via Cortactin.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lian Y, Wen D, Meng X, Wang X, Li H, Hao L, Xue H and Zhao J: Inhibition of invadopodia formation by diosgenin in tumor cells (Review). Oncol Lett 20: 283, 2020
APA
Lian, Y., Wen, D., Meng, X., Wang, X., Li, H., Hao, L. ... Zhao, J. (2020). Inhibition of invadopodia formation by diosgenin in tumor cells (Review). Oncology Letters, 20, 283. https://doi.org/10.3892/ol.2020.12148
MLA
Lian, Y., Wen, D., Meng, X., Wang, X., Li, H., Hao, L., Xue, H., Zhao, J."Inhibition of invadopodia formation by diosgenin in tumor cells (Review)". Oncology Letters 20.6 (2020): 283.
Chicago
Lian, Y., Wen, D., Meng, X., Wang, X., Li, H., Hao, L., Xue, H., Zhao, J."Inhibition of invadopodia formation by diosgenin in tumor cells (Review)". Oncology Letters 20, no. 6 (2020): 283. https://doi.org/10.3892/ol.2020.12148