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Expression and clinical correlation of Survivin and PTEN in gastric cancer patients

  • Authors:
    • Aikeremu Yusufu
    • Rousidan Tuerdi
    • Darebai Redati
    • Aizimaiti Rehemutula
    • Ze-Liang Zhao
    • Hai-Jiang Wang

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  • Published online on: September 28, 2020     https://doi.org/10.3892/ol.2020.12160
  • Article Number: 297

  • Copyright: © Yusufu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Reports on the correlation between the expression of Survivin/phosphatase and tensin homolog (PTEN) proteins and clinical factors in gastric cancer (GC) are varied, and the sample sizes were also not sufficient. The present study aimed to detect the expression of Survivin and PTEN proteins in GC patients on the basis of a greater number of specimens and to analyze the correlation with clinical features and survival. The results revealed that the Survivin expression rates in GC, normal tissues and metastatic lymph nodes were 72% (232/322), 5% (6/120) and 80% (36/45), respectively, while the PTEN expression rates were 34% (109/322), 92.5% (111/120) and 24.4% (11/45), respectively, and the differences between cancer and normal tissue or metastatic lymph nodes were significant for both proteins (P<0.05). The expression of Survivin was significantly associated with gross type, depth of invasion, distant metastasis, tumor, necrosis and metastasis (TNM) stage and vascular invasion, while PTEN expression was predominantly associated with age, tumor size, invasion depth, TNM stage and lymphatic invasion in GC patients (P<0.05). The expression of both was associated with postoperative metastasis and metastatic site (P=0.007 and P=0.011 for Survivin, and P=0.002 and P=0.005 for PTEN). There was a negative association between the expression levels of Survivin and PTEN (P=0.001, r=‑0.524). The expression levels of both were also associated with prognosis. The expression of Survivin and PTEN protein exhibit opposing trends in GC, which may indicate adverse biological effects in the occurrence of GC. The Survivin and PTEN expression levels are likely to be an important molecular event in gastric tumorigenesis and may be considered as molecular markers of GC progression and reliable prognostic indicators of GC.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yusufu A, Tuerdi R, Redati D, Rehemutula A, Zhao Z and Wang H: Expression and clinical correlation of Survivin and PTEN in gastric cancer patients. Oncol Lett 20: 297, 2020
APA
Yusufu, A., Tuerdi, R., Redati, D., Rehemutula, A., Zhao, Z., & Wang, H. (2020). Expression and clinical correlation of Survivin and PTEN in gastric cancer patients. Oncology Letters, 20, 297. https://doi.org/10.3892/ol.2020.12160
MLA
Yusufu, A., Tuerdi, R., Redati, D., Rehemutula, A., Zhao, Z., Wang, H."Expression and clinical correlation of Survivin and PTEN in gastric cancer patients". Oncology Letters 20.6 (2020): 297.
Chicago
Yusufu, A., Tuerdi, R., Redati, D., Rehemutula, A., Zhao, Z., Wang, H."Expression and clinical correlation of Survivin and PTEN in gastric cancer patients". Oncology Letters 20, no. 6 (2020): 297. https://doi.org/10.3892/ol.2020.12160