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Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma

  • Authors:
    • Hong-Tao Li
    • Bing Wei
    • Zhou-Quan Li
    • Xiao Wang
    • Wen-Xian Jia
    • Yan-Zhen Xu
    • Jia-Yi Liu
    • Meng-Nan Shao
    • Sui-Xia Chen
    • Nan-Fang Mo
    • Dong Zhao
    • Wen-Pu Zuo
    • Jian Qin
    • Ping Li
    • Qin-Le Zhang
    • Xiao-Li Yang
  • View Affiliations / Copyright

    Affiliations: Scientific Research Center, Guilin Medical University, Guilin, Guangxi 541100, P.R. China, College of International Education, Guilin Medical University, Guilin, Guangxi 541100, P.R. China, College of Pharmacy, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Pathology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Genetic and Metabolic Central Laboratory, The Maternal and Children Health Hospital of Guangxi, Nanning, Guangxi 530005, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 308
    |
    Published online on: September 30, 2020
       https://doi.org/10.3892/ol.2020.12171
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Abstract

Aberrant DNA replication is one of the driving forces behind oncogenesis. Furthermore, minichromosome maintenance complex component 3 (MCM3) serves an essential role in DNA replication. Therefore, in the present study, the diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma (HCC) were investigated. By utilizing The Cancer Genome Atlas (TCGA) database, global MCM3 mRNA levels were assessed in HCC and normal liver tissues. Its effects were further analyzed by reverse transcription‑quantitative PCR (RT‑qPCR), western blotting and immunohistochemistry in 78 paired HCC and adjacent tissues. Functional and pathway enrichment analyses were performed using the Search Tool for the Retrieval of Interacting Genes database. The expression levels of proteins that interact with MCM3 were also analyzed using the TCGA database and RT‑qPCR. Finally, algorithms combining receiver operating characteristic (ROC) curves were constructed using binary logistic regression using the TCGA results. Increased MCM3 mRNA expression with high α‑fetoprotein levels and advanced Edmondson‑Steiner grade were found to be characteristic of HCC. Survival analysis revealed that high MCM3 expression was associated with poor outcomes in patients with HCC. In addition, MCM3 protein expression was associated with increased tumor invasion in HCC tissues. MCM3 and its interacting proteins were found to be primarily involved in DNA replication, cell cycle and a number of binding processes. Algorithms combining ROCs of MCM3 and its interacting proteins were found to have improved HCC diagnosis ability compared with MCM3 and other individual diagnostic markers. In conclusion, MCM3 appears to be a promising diagnostic biomarker for HCC. Additionally, the present study provides a basis for the multi‑gene diagnosis of HCC using MCM3.
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View References

1 

Maiorano D, Lutzmann M and Mechali M: MCM proteins and DNA replication. Curr Opin Cell Biol. 18:130–136. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Forsburg SL: Eukaryotic MCM proteins: Beyond replication initiation. Microbiol Mol Biol Rev. 68:109–131. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Lee JK and Hurwitz J: Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe. J Biol Chem. 275:18871–18878. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Takei Y and Tsujimoto G: Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. J Biol Chem. 273:22177–22180. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Stewart PA, Khamis ZI, Zhau HE, Duan P, Li Q, Chung LWK and Sang QA: Upregulation of minichromosome maintenance complex component 3 during epithelial-to-mesenchymal transition in human prostate cancer. Oncotarget. 8:39209–39217. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs TM, Cloer EW, Harrison JS, Vaziri C, Cook JG and Major MB: Identification and characterization of MCM3 as a Kelch-like ECH-associated protein 1 (KEAP1) substrate. J Biol Chem. 291:23719–23733. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Guo J, Ma Z, Ma Q, Wu Z, Fan P, Zhou X, Chen L, Zhou S, Goltzman D, Miao D and Wu E: 1, 25(OH)2D3 inhibits hepatocellular carcinoma development through reducing secretion of inflammatory cytokines from immunocytes. Curr Med Chem. 20:4131–4141. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Liu D, Staveley-O'Carroll KF and Li G: Immune-based therapy clinical trials in hepatocellular carcinoma. J Clin Cell Immunol. 6:3762015. View Article : Google Scholar : PubMed/NCBI

9 

Kim HS and El-Serag HB: The epidemiology of hepatocellular carcinoma in the USA. Curr Gastroenterol Rep. 21:172019. View Article : Google Scholar : PubMed/NCBI

10 

Cui J, Zhou XD, Liu YK, Tang ZY and Zile MH: Abnormal beta-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China. World J Gastroenterol. 7:542–546. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Ishibashi Y, Kinugasa T, Akagi Y, Ohchi T, Gotanda Y, Tanaka N, Fujino S, Yuge K, Kibe S, Yoshida N, et al: Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer. Anticancer Res. 34:4569–4575. 2014.PubMed/NCBI

12 

Kato K, Toki T, Shimizu M, Shiozawa T, Fujii S, Nikaido T and Konishi I: Expression of replication-licensing factors MCM2 and MCM3 in normal, hyperplastic, and carcinomatous endometrium: Correlation with expression of Ki-67 and estrogen and progesterone receptors. Int J Gynecol Pathol. 22:334–340. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Lau KM, Chan QK, Pang JC, Li KK, Yeung WW, Chung NY, Lui PC, Tam YS, Li HM, Zhou L, et al: Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: Overexpression and involvement in regulation of cell migration and invasion. Oncogene. 29:5475–5489. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Chevalier S and Blow JJ: Cell cycle control of replication initiation in eukaryotes. Curr Opin Cell Biol. 8:815–821. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Carreon-Burciaga RG, Gonzalez-Gonzalez R, Molina-Frechero N and Bologna-Molina R: Immunoexpression of Ki-67, MCM2, and MCM3 in ameloblastoma and ameloblastic carcinoma and their correlations with clinical and histopathological patterns. Dis Markers. 2015:6830872015. View Article : Google Scholar : PubMed/NCBI

16 

Zhou L, Wang SB, Chen SG, Qu Q and Rui JA: Prognostic value of ALT, AST, and AAR in hepatocellular carcinoma with B-Type hepatitis-associated cirrhosis after radical hepatectomy. Clin Lab. 64:1739–1747. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Bi X, Yan T, Zhao H, Zhao J, Li Z, Huang Z, Zhou J and Cai J: Correlation of alpha fetoprotein with the prognosis of hepatocellular carcinoma after hepatectomy in an ethnic Chinese population. Zhonghua Yi Xue Za Zhi. 94:2645–2649. 2014.(In Chinese). PubMed/NCBI

18 

Zhou J, Sun HC, Wang Z, Cong WM, Wang JH, Zeng MS, Yang JM, Bie P, Liu LX, Wen TF, et al: Guidelines for diagnosis and treatment of primary liver cancer in China (2017 edition). Liver Cancer. 7:235–260. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Zhou L, Rui JA, Zhou WX, Wang SB, Chen SG and Qu Q: Edmondson-Steiner grade: A crucial predictor of recurrence and survival in hepatocellular carcinoma without microvascular invasio. Pathol Res Pract. 213:824–830. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Shi K, Wang SL, Shen B, Yu FQ, Weng DF and Lin JH: Clinicopathological and prognostic values of fibronectin and integrin alphavbeta3 expression in primary osteosarcoma. World J Surg Oncol. 17:232019. View Article : Google Scholar : PubMed/NCBI

22 

Bader G and Hogue C: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

23 

Cai C, Wang W and Tu Z: Aberrantly DNA methylated-differentially expressed genes and pathways in hepatocellular carcinoma. J Cancer. 10:355–366. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Korner T, Kropf J, Kosche B, Kristahl H, Jaspersen D and Gressner AM: Improvement of prognostic power of the Child-Pugh classification of liver cirrhosis by hyaluronan. J Hepatol. 39:947–953. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Stead BE, Sorbara CD, Brandl CJ and Davey MJ: ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes. J Mol Biol. 391:301–313. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Zhuang L, Yang Z and Meng Z: Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in tumor tissues predicted worse overall survival and disease-Free survival in hepatocellular carcinoma patients. Biomed Res Int. 2018:78973462018. View Article : Google Scholar : PubMed/NCBI

27 

Liao X, Liu X, Yang C, Wang X, Yu T, Han C, Huang K, Zhu G, Su H, Qin W, et al: Distinct diagnostic and prognostic values of minichromosome maintenance gene expression in patients with hepatocellular carcinoma. J Cancer. 9:2357–2373. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Liu Y, Zhang Y, Zhao Y, Gao D, Xing J and Liu H: High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. Oncol Lett. 12:3825–3835. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Chatterjee D, Rashid A, Wang H, Katz MH, Wolff RA, Varadhachary GR, Lee JE, Pisters PW, Gomez HF, Abbruzzese JL, et al: Tumor invasion of muscular vessels predicts poor prognosis in patients with pancreatic ductal adenocarcinoma who have received neoadjuvant therapy and pancreaticoduodenectomy. Am J Surg Pathol. 36:552–559. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Hong SM, Pawlik TM, Cho H, Aggarwal B, Goggins M, Hruban RH and Anders RA: Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma. Surgery. 146:250–257. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Bi XW, Zhang WW, Li ZM, Huang JJ, Xia Y, Sun P, Wang Y and Jiang WQ: The extent of local tumor invasion predicts prognosis in stage IE nasal natural killer/T-cell lymphoma: A novel T staging system for risk stratification. Ann Hematol. 94:1515–1524. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Fan J, Tang ZY, Wu ZQ, Zhou J, Zhou XD, Ma ZC, Qin LX, Qiu SJ, Yu Y and Huang C: The effects of portal vein microscopic and macroscopic tumor thrombi on post-operation patients with hepatocellular carcinoma. Zhonghua Wai Ke Za Zhi. 43:433–435. 2005.(In Chinese). PubMed/NCBI

33 

Ryu S and Driever W: Minichromosome maintenance proteins as markers for proliferation zones during embryogenesis. Cell Cycle. 5:1140–1142. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Lei M: The MCM complex: Its role in DNA replication and implications for cancer therapy. Curr Cancer Drug Targets. 5:365–380. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Chuang CH, Yang D, Bai G, Freeland A, Pruitt SC and Schimenti JC: Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells. Nucleic Acids Res. 40:4914–4924. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Juríková M, Danihel Ľ, Polák Š and Varga I: Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer. Acta Histochem. 118:544–552. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Hua C, Zhao G, Li Y and Bie L: Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas. BMC Cancer. 14:5262014. View Article : Google Scholar : PubMed/NCBI

38 

Cheng DD, Zhang HZ, Yuan JQ, Li SJ, Yang QC and Fan CY: Minichromosome maintenance protein 2 and 3 promote osteosarcoma progression via DHX9 and predict poor patient prognosis. Oncotarget. 8:26380–26393. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F and Zhou WP: Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. J Hepatol. 68:1214–1227. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Cao S, Sun R, Wang W, Meng X, Zhang Y, Zhang N and Yang S: RNA helicase DHX9 may be a therapeutic target in lung cancer and inhibited by enoxacin. Am J Transl Res. 9:674–682. 2017.PubMed/NCBI

41 

Mi J, Ray P, Liu J, Kuan CT, Xu J, Hsu D, Sullenger BA, White RR and Clary BM: In vivo selection against human colorectal cancer xenografts identifies an aptamer that targets RNA helicase protein DHX9. Mol Ther Nucleic Acids. 5:e3152016. View Article : Google Scholar : PubMed/NCBI

42 

Lee T, Paquet M, Larsson O and Pelletier J: Tumor cell survival dependence on the DHX9 DExH-box helicase. Oncogene. 35:5093–5105. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Fidaleo M, Svetoni F, Volpe E, Minana B, Caporossi D and Paronetto MP: Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9. Oncotarget. 6:31740–31757. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Zhang Y and Hunter T: Roles of Chk1 in cell biology and cancer therapy. Int J Cancer. 134:1013–1023. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Jin H, Xu G, Zhang Q, Pang Q and Fang M: Synaptotagmin-7 is overexpressed in hepatocellular carcinoma and regulates hepatocellular carcinoma cell proliferation via Chk1-p53 signaling. Onco Targets Ther. 10:4283–4293. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Hong J, Hu K, Yuan Y, Sang Y, Bu Q, Chen G, Yang L, Li B, Huang P, Chen D, et al: CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma. J Clin Invest. 122:2165–2175. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Han X, Mayca Pozo F, Wisotsky JN, Wang B, Jacobberger JW and Zhang Y: Phosphorylation of minichromosome maintenance 3 (MCM3) by checkpoint kinase 1 (Chk1) negatively regulates DNA replication and checkpoint activation. J Biol Chem. 290:12370–12378. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Kitao H, Iimori M, Kataoka Y, Wakasa T, Tokunaga E, Saeki H, Oki E and Maehara Y: DNA replication stress and cancer chemotherapy. Cancer Sci. 109:264–271. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Xu D, Su C, Sun L, Gao Y and Li Y: Performance of serum glypican 3 in diagnosis of hepatocellular carcinoma: A meta-analysis. Ann Hepatol. 18:58–67. 2018. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Wei B, Li Z, Wang X, Jia W, Xu Y, Liu J, Shao M, Chen S, Mo N, Mo N, et al: Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma. Oncol Lett 20: 308, 2020.
APA
Li, H., Wei, B., Li, Z., Wang, X., Jia, W., Xu, Y. ... Yang, X. (2020). Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma. Oncology Letters, 20, 308. https://doi.org/10.3892/ol.2020.12171
MLA
Li, H., Wei, B., Li, Z., Wang, X., Jia, W., Xu, Y., Liu, J., Shao, M., Chen, S., Mo, N., Zhao, D., Zuo, W., Qin, J., Li, P., Zhang, Q., Yang, X."Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma". Oncology Letters 20.6 (2020): 308.
Chicago
Li, H., Wei, B., Li, Z., Wang, X., Jia, W., Xu, Y., Liu, J., Shao, M., Chen, S., Mo, N., Zhao, D., Zuo, W., Qin, J., Li, P., Zhang, Q., Yang, X."Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma". Oncology Letters 20, no. 6 (2020): 308. https://doi.org/10.3892/ol.2020.12171
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Wei B, Li Z, Wang X, Jia W, Xu Y, Liu J, Shao M, Chen S, Mo N, Mo N, et al: Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma. Oncol Lett 20: 308, 2020.
APA
Li, H., Wei, B., Li, Z., Wang, X., Jia, W., Xu, Y. ... Yang, X. (2020). Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma. Oncology Letters, 20, 308. https://doi.org/10.3892/ol.2020.12171
MLA
Li, H., Wei, B., Li, Z., Wang, X., Jia, W., Xu, Y., Liu, J., Shao, M., Chen, S., Mo, N., Zhao, D., Zuo, W., Qin, J., Li, P., Zhang, Q., Yang, X."Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma". Oncology Letters 20.6 (2020): 308.
Chicago
Li, H., Wei, B., Li, Z., Wang, X., Jia, W., Xu, Y., Liu, J., Shao, M., Chen, S., Mo, N., Zhao, D., Zuo, W., Qin, J., Li, P., Zhang, Q., Yang, X."Diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma". Oncology Letters 20, no. 6 (2020): 308. https://doi.org/10.3892/ol.2020.12171
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