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Article Open Access

Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells

Corrigendum in: /10.3892/ol.2023.13888
  • Authors:
    • Neeraj Kumar Rai
    • Shashank Mathur
    • Suraj Kumar Singh
    • Meenakshi Tiwari
    • Vijay Kumar Singh
    • Rizwanul Haque
    • Swasti Tiwari
    • Lokendra Kumar Sharma
  • View Affiliations / Copyright

    Affiliations: Department of Biotechnology, Central University of South Bihar, Gaya, Bihar 824236, India, Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India, Department of Pathology/Lab Medicine, All India Institute of Medical Sciences‑Patna, Patna, Bihar 801507, India, Department of Bioinformatics, Central University of South Bihar, Gaya, Bihar 824236, India
    Copyright: © Rai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 313
    |
    Published online on: September 30, 2020
       https://doi.org/10.3892/ol.2020.12176
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Abstract

Mitochondria serve a vital role in cellular homeostasis as they regulate cell proliferation and death pathways, which are attributed to mitochondrial bioenergetics, free radicals and metabolism. Alterations in mitochondrial functions have been reported in various diseases, including cancer. Colorectal cancer (CRC) is one of the most common metastatic cancer types with high mortality rates. Although mitochondrial oxidative stress has been associated with CRC, its specific mechanism and contribution to metastatic progression remain poorly understood. Therefore, the aims of the present study were to investigate the role of mitochondria in CRC cells with low and high metastatic potential and to evaluate the contribution of mitochondrial respiratory chain (RC) complexes in oncogenic signaling pathways. The present results demonstrated that cell lines with low metastatic potential were resistant to mitochondrial complex I (C‑I)‑mediated oxidative stress, and had C‑I inhibition with impaired mitochondrial functions. These adaptations enabled cells to cope with higher oxidative stress. Conversely, cells with high metastatic potential demonstrated functional C‑I with improved mitochondrial function due to coordinated upregulation of mitochondrial biogenesis and metabolic reprogramming. Pharmacological inhibition of C‑I in high metastatic cells resulted in increased sensitivity to cell death and decreased metastatic signaling. The present findings identified the differential regulation of mitochondrial functions in CRC cells, based on CRC metastatic potential. Specifically, it was suggested that a functional C‑I is required for high metastatic features of cancer cells, and the role of C‑I could be further examined as a potential target in the development of novel therapies for diagnosing high metastatic cancer types.
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Spandidos Publications style
Rai NK, Mathur S, Singh SK, Tiwari M, Singh VK, Haque R, Tiwari S and Sharma LK: Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells Corrigendum in /10.3892/ol.2023.13888. Oncol Lett 20: 313, 2020.
APA
Rai, N.K., Mathur, S., Singh, S.K., Tiwari, M., Singh, V.K., Haque, R. ... Sharma, L.K. (2020). Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells Corrigendum in /10.3892/ol.2023.13888. Oncology Letters, 20, 313. https://doi.org/10.3892/ol.2020.12176
MLA
Rai, N. K., Mathur, S., Singh, S. K., Tiwari, M., Singh, V. K., Haque, R., Tiwari, S., Sharma, L. K."Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells Corrigendum in /10.3892/ol.2023.13888". Oncology Letters 20.6 (2020): 313.
Chicago
Rai, N. K., Mathur, S., Singh, S. K., Tiwari, M., Singh, V. K., Haque, R., Tiwari, S., Sharma, L. K."Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells Corrigendum in /10.3892/ol.2023.13888". Oncology Letters 20, no. 6 (2020): 313. https://doi.org/10.3892/ol.2020.12176
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Spandidos Publications style
Rai NK, Mathur S, Singh SK, Tiwari M, Singh VK, Haque R, Tiwari S and Sharma LK: Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells Corrigendum in /10.3892/ol.2023.13888. Oncol Lett 20: 313, 2020.
APA
Rai, N.K., Mathur, S., Singh, S.K., Tiwari, M., Singh, V.K., Haque, R. ... Sharma, L.K. (2020). Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells Corrigendum in /10.3892/ol.2023.13888. Oncology Letters, 20, 313. https://doi.org/10.3892/ol.2020.12176
MLA
Rai, N. K., Mathur, S., Singh, S. K., Tiwari, M., Singh, V. K., Haque, R., Tiwari, S., Sharma, L. K."Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells Corrigendum in /10.3892/ol.2023.13888". Oncology Letters 20.6 (2020): 313.
Chicago
Rai, N. K., Mathur, S., Singh, S. K., Tiwari, M., Singh, V. K., Haque, R., Tiwari, S., Sharma, L. K."Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer cells Corrigendum in /10.3892/ol.2023.13888". Oncology Letters 20, no. 6 (2020): 313. https://doi.org/10.3892/ol.2020.12176
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