Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

Trefoil factor 1 and gastrokine 2 inhibit Helicobacter pylori‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis

  • Authors:
    • Wenjing Liu
    • Jie Li
    • Di Zhang
    • Bao Chen
    • Xiaozi  Wang
    • Xianghong Zhang
    • Liying Xue
  • View Affiliations / Copyright

    Affiliations: Laboratory of Pathology, Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Hematology, Hebei General Hospital, Shijiazhuang, Hebei 050000, P.R. China
  • Article Number: 318
    |
    Published online on: October 1, 2020
       https://doi.org/10.3892/ol.2020.12181
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Helicobacter pylori (H. pylori) infection has been associated with non‑cardia adenocarcinoma in the stomach, while its role in gastric cardia adenocarcinoma (GCA) remains controversial. In addition, the association between H. pylori and the protective factors trefoil factor 1 (TFF1) and gastrokine 2 (GKN2) in gastroesophageal adenocarcinomas has not been fully investigated. Therefore, the mRNA and protein expression levels of TFF1 and GKN2 in GCA and distal gastric adenocarcinoma (DGA) were analyzed using quantitative PCR (qPCR) and immunohistochemistry, and the association with H. pylori infection was investigated. In addition, the effects of TFF1 and GKN2 overexpression on H. pylori‑induced cells were investigated using western blot and reverse transcription‑qPCR analysis. The comparative analysis of 16S rRNA‑positive mRNA expression between GCA and DGA showed no statistically significant difference. However, the rate of the H. pylori vacuolating toxin A (VacA) genotype was significantly higher in GCA (49.2%) compared with that in DGA (26.9%; P<0.05). H. pylori infection downregulated the mRNA and protein expression levels of TFF1 and GKN2 in gastric tumor tissues, and the mRNA expression level of TFF1 and GKN2 was also markedly decreased in vitro. Furthermore, the cell proliferation varied in H. pylori total protein treatment group with the different doses. Notably, treatment with 20 µg/ml H. pylori total protein for 24 h resulted in the highest cellular proliferation rate. In addition, TFF1 and GKN2 overexpression inversely inhibited H. pylori‑induced cell proliferation and upregulated NF‑κB, tumor necrosis factor‑α, IL‑1β, IL‑2, IL‑4 and IL‑6. The results of the present study indicate that H. pylori, particularly the VacA+ strain, plays an important role in GCA pathogenesis in high‑risk areas of China, while TFF1/GKN2 inhibits H. pylori‑induced cell proliferation and inflammation in GCA and DGA.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Zhao CY, Zhang XH, Xue LY, Xing LX, Wang JL, Li XM, Mi JM and Jin GL: Analysis of the changing trends of frequency and localization of gastric cancers arising from different sites of the stomach in population of the high incidence area of esophageal and gastric cancers in Hebei province. Zhonghua Zhong Liu Za Zhi. 30:817–820. 2008.(In Chinese). PubMed/NCBI

2 

Dent J: Pathogenesis and classification of cancer around the gastroesophageal junction-not so different in Japan. Am J Gastroenterol. 101:934–936. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Mattioli S, Ruffato A, Di Simone MP, Corti B, D'Errico A, Lugaresi ML, Mattioli B and D'Ovidio F: Immunopathological patterns of the stomach in adenocarcinoma of the esophagus, cardia, and gastric antrum: Gastric profiles in Siewert type I and II tumors. Ann Thorac Surg. 83:1814–1819. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Zhou Y, Zhang Z, Zhang Z, Wu J, Ren D, Yan X, Wang Q, Wang Y, Wang H, Zhang J, et al: A rising trend of gastric cardia cancer in Gansu Province of China. Cancer Lett. 269:18–25. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Malhotra GK, Yanala U, Ravipati A, Follet M, Vijayakumar M and Are C: Global trends in esophageal cancer. J Surg Oncol. 115:564–579. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Petrick JL, Hyland PL, Caron P, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Weinstein SJ, Albanes D, et al: Associations between prediagnostic concentrations of circulating sex steroid hormones and esophageal/gastric cardia adenocarcinoma among men. J Natl Cancer Inst. 111:34–41. 2019. View Article : Google Scholar : PubMed/NCBI

7 

He Y, Hou J, Liu T and Zhang G: The association between cancer mortality and socioeconomy status from 1990–1992 in Hebei province, China. China Tumor Bull. 5:111996.(In Chinese).

8 

Zhao P and Kong LZ: Mortality Rate of Stomach Cancer: Cancer Mortality in China. People's Health Press; Beijing: 307. 2009

9 

Xue L, Zhang X, Li Y, Yang H, Li X, Mi J, Wang H, Wang J and Yan X: Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach. Hum Pathol. 42:594–601. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Xue L, Ouyang Q, Li J, Meng X, Li Y, Xing L, Wang J, Yan X and Zhang X: Different roles for p16(INK) (4a)-Rb pathway and INK4a/ARF methylation between adenocarcinomas of gastric cardia and distal stomach. J Gastroenterol Hepatol. 29:1418–1426. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Yao D, Wang Y, Xue L, Wang H, Zhang J and Zhang X: Different expression pattern and significance of p14ARF-Mdm2-p53 pathway and Bmi-1 exist between gastric cardia and distal gastric adenocarcinoma. Hum Pathol. 44:844–851. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Hu N, Wang Z, Song X, Wei L, Kim BS, Freedman ND, Baek J, Burdette L, Chang J, Chung C, et al: Genome-wide association study of gastric adenocarcinoma in Asia: A comparison of associations between cardia and non-cardia tumours. Gut. 65:1611–1618. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Zhang X, Xue L, Xing L, Wang J, Cui J, Mi J, Xing X, Wang J, Du Z, Misumi J, et al: Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community. Int J Cancer. 130:1614–1619. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Backert S and Blaser MJ: The role of CagA in the gastric biology of Helicobacter pylori. Cancer Res. 76:4028–4031. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Derakhshan MH, Malekzadeh R, Watabe H, Yazdanbod A, Fyfe V, Kazemi A, Rakhshani N, Didevar R, Sotoudeh M, Zolfeghari AA and McColl KE: Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. Gut. 57:298–305. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Sanikini H, Muller DC, Sophiea M, Rinaldi S, Agudo A, Duell EJ, Weiderpass E, Overvad K, Tjønneland A, Halkjaer J, et al: Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European prospective investigation into cancer and nutrition (EPIC) cohort. Int J Cancer. 146:929–942. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Chow WH, Blaser MJ, Blot WJ, Gammon MD, Vaughan TL, Risch HA, Perez-Perez GI, Schoenberg JB, Stanford JL, Rotterdam H, et al: An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma. Cancer Res. 58:588–590. 1998.PubMed/NCBI

18 

Wang Y, Liu S, Zhang Y, Bi C, Xiao Y, Lin R, Huang B, Tian D, Ying S and Su M: Helicobacter pylori infection and gastric cardia cancer in Chaoshan region. Microbes Infect. 16:840–844. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Y, Wang H, Bi C, Xiao Y and Liu Z: Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation. Oncotarget. 7:54973–54982. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Cai M, Dai S, Chen W, Xia C, Lu L, Dai S, Qi J, Wang M, Wang M, Zhou L, et al: Environmental factors, seven GWAS-identified susceptibility loci, and risk of gastric cancer and its precursors in a Chinese population. Cancer Med. 6:708–720. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Aihara E, Engevik KA and Montrose MH: Trefoil factor peptides and gastrointestinal function. Annu Rev Physiol. 79:357–380. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Soutto M, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe SE, Zaika A, et al: Loss of TFF1 is associated with activation of NF-κB-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest. 121:1753–1767. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Omar OM, Soutto M, Bhat NS, Bhat AA, Lu H, Chen Z and El-Rifai W: TFF1 antagonizes TIMP-1 mediated proliferative functions in gastric cancer. Mol Carcinog. 57:1577–1587. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Soutto M, Peng D, Katsha A, Chen Z, Piazuelo MB, Washington MK, Belkhiri A, Correa P and El-Rifai W: Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. Gut. 64:1028–1039. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Kouznetsova I, Laubinger W, Kalbacher H, Kalinski T, Meyer F, Roessner A and Hoffmann W: Biosynthesis of gastrokine-2 in the human gastric mucosa: Restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins. Cell Physiol Biochem. 20:899–908. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Menheniott TR, O'Connor L, Chionh YT, Däbritz J, Scurr M, Rollo BN, Ng GZ, Jacobs S, Catubig A, Kurklu B, et al: Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression. J Clin Invest. 126:1383–1400. 2016. View Article : Google Scholar : PubMed/NCBI

27 

May FE, Griffin SM and Westley BR: The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer. Int J Biochem Cell Biol. 41:632–640. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Heuer J, Heuer F, Stürmer R, Harder S, Schlüter H, Braga Emidio N, Muttenthaler M, Jechorek D, Meyer F and Hoffmann W: The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier: Indications for diverse protective functions. Int J Mol Sci. 21:25082020. View Article : Google Scholar

29 

Siewert JR, Stein HJ and Feith M: Adenocarcinoma of the esophago-gastric junction. Scand J Surg. 95:260–269. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Pathak SK, Tavares R, de Klerk N, Spetz AL and Jonsson AB: Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PLoS One. 8:e778722013. View Article : Google Scholar : PubMed/NCBI

32 

Tavares R and Pathak SK: Helicobacter pylori protein JHP0290 exhibits proliferative and anti-apoptotic effects in gastric epithelial cells. PLoS One. 10:e01244072015. View Article : Google Scholar : PubMed/NCBI

33 

Li J, Meng FL, He LH and Zhang JZ: Secreted protein HP1286 of Helicobacter pylori strain 26695 induces apoptosis of AGS cells. Biomed Environ Sci. 25:614–619. 2012.PubMed/NCBI

34 

Alarcón-Millán J, Lorenzo-Nazario SI, Jiménez-Wences H, Campos-Viguri GE, Ortiz-Ortiz J, Mendoza-Catalán MÁ, Cortés-Malagón EM, Reyes-Navarrete S, Jiménez-López MA, Castañón-Sánchez CA, et al: Women with chronic follicular gastritis positive for Helicobacter pylori express lower levels of GKN1. Gastric Cancer. 23:754–759. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Yoon J, Ashktorab H, Smoot D, Nam S, Hur H and Park W: Uptake and tumor-suppressive pathways of exosome-associated GKN1 protein in gastric epithelial cells. Gastric Cancer. 23:848–862. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Moss SF, Lee JW, Sabo E, Rubin AK, Rommel J, Westley BR, May FE, Gao J, Meitner PA, Tavares R and Resnick MB: Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: Influence of tumor histology and relationship to prognosis. Clin Cancer Res. 14:4161–4167. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Kamada T, Kurose H, Yamanaka Y, Manabe N, Kusunoki H, Shiotani A, Inoue K, Hata J, Matsumoto H, Akiyama T, et al: Relationship between gastroesophageal junction adenocarcinoma and Helicobacter pylori infection in Japan. Digestion. 85:256–260. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Wang F, Meng W, Wang B and Qiao L: Helicobacter pylori- induced gastric inflammation and gastric cancer. Cancer Lett. 345:196–202. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Shakeri R, Malekzadeh R, Nasrollahzadeh D, Pawlita M, Murphy G, Islami F, Sotoudeh M, Michel A, Etemadi A, Waterboer T, et al: Multiplex H. pylori serology and risk of gastric cardia and noncardia adenocarcinomas. Cancer Res. 75:4876–4883. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T, et al: Management of Helicobacter pylori infection-the maastricht IV/florence consensus report. Gut. 61:646–664. 2012. View Article : Google Scholar : PubMed/NCBI

41 

el Serag HB and Sonnenberg A: Opposing time trends of peptic ulcer and reflux disease. Gut. 43:327–333. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Erőss B, Farkas N, Vincze Á, Tinusz B, Szapáry L, Garami A, Balaskó M, Sarlós P, Czopf L, Alizadeh H, et al: Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta-analysis and systematic review. Helicobacter. 23:e125042018. View Article : Google Scholar : PubMed/NCBI

43 

Rassow J: Helicobacter pylori vacuolating toxin A and apoptosis. Cell Commun Signal. 9:262011. View Article : Google Scholar : PubMed/NCBI

44 

Chauhan N, Tay ACY, Marshall BJ and Jain U: Helicobacter pylori VacA, a distinct toxin exerts diverse functionalities in numerous cells: An overview. Helicobacter. 24:e125442019. View Article : Google Scholar : PubMed/NCBI

45 

Tomita H, Takaishi S, Menheniott TR, Yang X, Shibata W, Jin G, Betz KS, Kawakami K, Minamoto T, Tomasetto C, et al: Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing. Gastroenterology. 140:879–891. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Wang W, Li Z, Wang J, Du M, Li B, Zhang L, Li Q, Xu J, Wang L, Li F, et al: A functional polymorphism in TFF1 promoter is associated with the risk and prognosis of gastric cancer. Int J Cancer. 142:1805–1816. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Kim O, Yoon JH, Choi WS, Ashktorab H, Smoot DT, Nam SW, Lee JY and Park WS: Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells. Gastric Cancer. 20:772–783. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Wroblewski LE, Peek RM Jr and Wilson KT: Helicobacter pylori and gastric cancer: Factors that modulate disease risk. Clin Microbiol Rev. 23:713–739. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Soutto M, Saleh M, Arredouani MS, Piazuelo B, Belkhiri A and El-Rifai W: Loss of Tff1 promotes pro-inflammatory phenotype with increase in the levels of RORγt+ T lymphocytes and Il-17 in mouse gastric neoplasia. J Cancer. 8:2424–2435. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Soutto M, Chen Z, Katsha AM, Romero-Gallo J, Krishna US, Piazuelo MB, Washington MK, Peek RM Jr, Belkhiri A and El-Rifai WM: Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis. Cancer. 121:4348–4358. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Zhang Z, Xue H, Dong Y, Hu J, Jiang T, Shi L and Du J: Inhibition of GKN2 attenuates acute gastric lesions through the NLRP3 inflammasome. Adv Wound Care (New Rochelle). 9:219–232. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Wilhelm A, Aldridge V, Haldar D, Naylor AJ, Weston CJ, Hedegaard D, Garg A, Fear J, Reynolds GM, Croft AP, et al: CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism. Gut. 65:1175–1185. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Cabral MM, Oliveira CA, Mendes CM, Guerra J, Queiroz DM, Rocha GA, Rocha AM and Nogueira AM: Gastric epithelial cell proliferation and cagA status in Helicobacter pylori gastritis at different gastric sites. Scand J Gastroenterol. 42:545–554. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, Aburatani H, Akiyama T, Peek RM Jr, Azuma T and Hatakeyama M: Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene. 26:4617–4626. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Kang D, Gong Y, Zhu Y, Li A, Dong N, Piao Y and Yuan Y: The biological activity of H. pylori SlyD in vitro. Helicobacter. 18:347–355. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu W, Li J, Zhang D, Chen B, Wang X, Zhang X and Xue L: Trefoil factor 1 and gastrokine 2 inhibit <em>Helicobacter&nbsp;pylori</em>‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis. Oncol Lett 20: 318, 2020.
APA
Liu, W., Li, J., Zhang, D., Chen, B., Wang, X., Zhang, X., & Xue, L. (2020). Trefoil factor 1 and gastrokine 2 inhibit <em>Helicobacter&nbsp;pylori</em>‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis. Oncology Letters, 20, 318. https://doi.org/10.3892/ol.2020.12181
MLA
Liu, W., Li, J., Zhang, D., Chen, B., Wang, X., Zhang, X., Xue, L."Trefoil factor 1 and gastrokine 2 inhibit <em>Helicobacter&nbsp;pylori</em>‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis". Oncology Letters 20.6 (2020): 318.
Chicago
Liu, W., Li, J., Zhang, D., Chen, B., Wang, X., Zhang, X., Xue, L."Trefoil factor 1 and gastrokine 2 inhibit <em>Helicobacter&nbsp;pylori</em>‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis". Oncology Letters 20, no. 6 (2020): 318. https://doi.org/10.3892/ol.2020.12181
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Li J, Zhang D, Chen B, Wang X, Zhang X and Xue L: Trefoil factor 1 and gastrokine 2 inhibit <em>Helicobacter&nbsp;pylori</em>‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis. Oncol Lett 20: 318, 2020.
APA
Liu, W., Li, J., Zhang, D., Chen, B., Wang, X., Zhang, X., & Xue, L. (2020). Trefoil factor 1 and gastrokine 2 inhibit <em>Helicobacter&nbsp;pylori</em>‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis. Oncology Letters, 20, 318. https://doi.org/10.3892/ol.2020.12181
MLA
Liu, W., Li, J., Zhang, D., Chen, B., Wang, X., Zhang, X., Xue, L."Trefoil factor 1 and gastrokine 2 inhibit <em>Helicobacter&nbsp;pylori</em>‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis". Oncology Letters 20.6 (2020): 318.
Chicago
Liu, W., Li, J., Zhang, D., Chen, B., Wang, X., Zhang, X., Xue, L."Trefoil factor 1 and gastrokine 2 inhibit <em>Helicobacter&nbsp;pylori</em>‑induced proliferation and inflammation in gastric cardia and distal carcinogenesis". Oncology Letters 20, no. 6 (2020): 318. https://doi.org/10.3892/ol.2020.12181
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team