Open Access

Molecular heterogeneity of guanine nucleotide binding‑protein γ subunit 4 in left‑ and right‑sided colon cancer

  • Authors:
    • Jintian Song
    • Jianwei Yang
    • Rongbo Lin
    • Xiongchao Cai
    • Liang Zheng
    • Yigui Chen
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  • Published online on: October 7, 2020     https://doi.org/10.3892/ol.2020.12197
  • Article Number: 334
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Molecular heterogeneity determines the differences in the pathological features, prognosis and survival after relapse when comparing left‑sided colon cancer (LCC) and right‑sided colon cancer (RCC). At present, the discrepancy in the underlying molecular events between the two types of colon cancer has not been thoroughly investigated. The present study aimed to explore novel targets to predict the disease stage and prognosis of LCC and RCC. Expression analysis of guanine nucleotide binding‑protein γ subunit 4 (GNG4) was performed using the Gene Expression Profiling Interactive Analysis (GEPIA) and Oncomine databases. Survival and association analyses were performed using GEPIA and the colon adenocarcinoma dataset from The Cancer Genome Atlas database. GNG4‑positive cells in a tissue microarray were examined using immunohistochemistry. According to the GNG4 expression data from Caucasian patients included in the TCGA dataset, GNG4 was highly expressed and positively associated with pathological stage and overall survival (OS) rates in colon cancer. GNG4 expression was higher in LCC than in RCC. Patients with LCC with high GNG4 expression exhibited higher pathological stage and lower survival rates, whereas this was not observed in patients with RCC. In addition, the clinical tissues used in the microarray showed that GNG4 expression was increased in Chinese patients with LCC compared with that in patients with RCC. Consistently, GNG4 expression was negatively associated with OS in patients with LCC, but not in patients with RCC. However, no association was observed between GNG4 expression and the disease stage of colon cancer in both patients with LCC and RCC. Overall, the molecular heterogeneity of GNG4 in LCC and RCC suggests that GNG4 may be used as a diagnostic and prognostic biomarker in patients with LCC.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Song J, Yang J, Lin R, Cai X, Zheng L and Chen Y: Molecular heterogeneity of guanine nucleotide binding‑protein γ subunit 4 in left‑ and right‑sided colon cancer. Oncol Lett 20: 334, 2020
APA
Song, J., Yang, J., Lin, R., Cai, X., Zheng, L., & Chen, Y. (2020). Molecular heterogeneity of guanine nucleotide binding‑protein γ subunit 4 in left‑ and right‑sided colon cancer. Oncology Letters, 20, 334. https://doi.org/10.3892/ol.2020.12197
MLA
Song, J., Yang, J., Lin, R., Cai, X., Zheng, L., Chen, Y."Molecular heterogeneity of guanine nucleotide binding‑protein γ subunit 4 in left‑ and right‑sided colon cancer". Oncology Letters 20.6 (2020): 334.
Chicago
Song, J., Yang, J., Lin, R., Cai, X., Zheng, L., Chen, Y."Molecular heterogeneity of guanine nucleotide binding‑protein γ subunit 4 in left‑ and right‑sided colon cancer". Oncology Letters 20, no. 6 (2020): 334. https://doi.org/10.3892/ol.2020.12197