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KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia

  • Authors:
    • Hyun-Jung Ahn
    • Byul Moon
    • Mijin Park
    • Jung-Ae Kim
  • View Affiliations / Copyright

    Affiliations: Personalized Genomic Medicine Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea
    Copyright: © Ahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 335
    |
    Published online on: October 7, 2020
       https://doi.org/10.3892/ol.2020.12199
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Abstract

Oxygen deprivation (hypoxia), which frequently occurs in the tumour microenvironment, is a strong driver of the phenotypic transition of cancer cells. An increase in metastatic potential such as cell invasion is a well‑known phenotypical change induced in hypoxia. The present study demonstrated that lysine demethylase 3A (KDM3A), a Jumonji C domain‑containing KDM, is involved in the hypoxia‑induced invasion of MCF7 breast cancer cells. KDM3A depletion inhibits the induction of cell invasion without affecting MCF7 cell survival rate or proliferation under hypoxic conditions, whereas KDM3A overexpression enhances MCF7 cell invasion even under normoxic conditions. KDM3A suppresses E‑cadherin expression, which is associated with epithelial‑to‑mesenchymal transition (EMT)‑mediated cell invasion in hypoxia. In addition, KDM3A promotes the expression of Slug, an EMT transcription factor that negatively regulates E‑cadherin expression. Consistent with this finding, the removal of the repressive transcription marker, dimethylated histone H3 at lysine 9 from the Slug promoter is dependent on hypoxia‑induced recruitment of KDM3A. Collectively, the results of the present study suggest that KDM3A is a crucial transcriptional coactivator of Slug expression to induce MCF7 breast cancer cell invasion in hypoxia, and that inhibition of KDM3A may efficaciously prevent metastatic cancer development.
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1 

Rankin EB, Nam JM and Giaccia AJ: Hypoxia: Signaling the Metastatic Cascade. Trends Cancer. 2:295–304. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Eales KL, Hollinshead KE and Tennant DA: Hypoxia and metabolic adaptation of cancer cells. Oncogenesis. 5:e1902016. View Article : Google Scholar : PubMed/NCBI

3 

Chouaib S, Messai Y, Couve S, Escudier B, Hasmim M and Noman MZ: Hypoxia promotes tumor growth in linking angiogenesis to immune escape. Front Immunol. 3:212012. View Article : Google Scholar : PubMed/NCBI

4 

Semenza GL: Hypoxia-inducible factors in physiology and medicine. Cell. 148:399–408. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Xia X, Lemieux ME, Li W, Carroll JS, Brown M, Liu XS and Kung AL: Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci USA. 106:4260–4265. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Hancock RL, Dunne K, Walport LJ, Flashman E and Kawamura A: Epigenetic regulation by histone demethylases in hypoxia. Epigenomics. 7:791–811. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Luo W, Chang R, Zhong J, Pandey A and Semenza GL: Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci USA. 109:E3367–E3376. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro J, et al: Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A. Mol Cell Biol. 32:3018–3032. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Lee HY, Yang EG and Park H: Hypoxia enhances the expression of prostate-specific antigen by modifying the quantity and catalytic activity of Jumonji C domain-containing histone demethylases. Carcinogenesis. 34:2706–2715. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Park SJ, Kim JG, Son TG, Yi JM, Kim ND, Yang K and Heo K: The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia. Biochem Biophys Res Commun. 434:722–727. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Ueda J, Ho JC, Lee KL, Kitajima S, Yang H, Sun W, Fukuhara N, Zaiden N, Chan SL, Tachibana M, et al: The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth. Mol Cell Biol. 34:3702–3720. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Favaro E, Lord S, Harris AL and Buffa FM: Gene expression and hypoxia in breast cancer. Genome Med. 3:552011. View Article : Google Scholar : PubMed/NCBI

13 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Serrano-Gomez SJ, Maziveyi M and Alahari SK: Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications. Mol Cancer. 15:182016. View Article : Google Scholar : PubMed/NCBI

15 

Jiang J, Tang YL and Liang XH: EMT: A new vision of hypoxia promoting cancer progression. Cancer Biol Ther. 11:714–723. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Flavahan WA, Gaskell E and Bernstein BE: Epigenetic plasticity and the hallmarks of cancer. Science. 357:eaal23802017. View Article : Google Scholar : PubMed/NCBI

17 

Perez-Perri JI, Acevedo JM and Wappner P: Epigenetics: New questions on the response to hypoxia. Int J Mol Sci. 12:4705–4721. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, et al: HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Proc Natl Acad Sci USA. 113:E7212–E7221. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Wan W, Peng K, Li M, Qin L, Tong Z, Yan J, Shen B and Yu C: Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α. Oncogene. 36:3868–3877. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Ramadoss S, Guo G and Wang CY: Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. Oncogene. 36:47–59. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Wade MA, Jones D, Wilson L, Stockley J, Coffey K, Robson CN and Gaughan L: The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer. Nucleic Acids Res. 43:196–207. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ahn H, Moon B, Park M and Kim J: KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia. Oncol Lett 20: 335, 2020.
APA
Ahn, H., Moon, B., Park, M., & Kim, J. (2020). KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia. Oncology Letters, 20, 335. https://doi.org/10.3892/ol.2020.12199
MLA
Ahn, H., Moon, B., Park, M., Kim, J."KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia". Oncology Letters 20.6 (2020): 335.
Chicago
Ahn, H., Moon, B., Park, M., Kim, J."KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia". Oncology Letters 20, no. 6 (2020): 335. https://doi.org/10.3892/ol.2020.12199
Copy and paste a formatted citation
x
Spandidos Publications style
Ahn H, Moon B, Park M and Kim J: KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia. Oncol Lett 20: 335, 2020.
APA
Ahn, H., Moon, B., Park, M., & Kim, J. (2020). KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia. Oncology Letters, 20, 335. https://doi.org/10.3892/ol.2020.12199
MLA
Ahn, H., Moon, B., Park, M., Kim, J."KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia". Oncology Letters 20.6 (2020): 335.
Chicago
Ahn, H., Moon, B., Park, M., Kim, J."KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia". Oncology Letters 20, no. 6 (2020): 335. https://doi.org/10.3892/ol.2020.12199
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