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Review Open Access

Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)

  • Authors:
    • Jian Wang
    • Hong-Ru Yang
    • Dai-Jie Wang
    • Xing-Xia Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Luzhou People's Hospital, Luzhou, Sichuan 646000, P.R. China, Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 342
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    Published online on: October 8, 2020
       https://doi.org/10.3892/ol.2020.12205
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Abstract

Studies are increasingly investigating the association between the gut microbiota and the outcomes of immunotherapy in patients with cancer. Notably, certain studies have demonstrated that the gut microbiota serves a key role in regulating a patient's response to immunotherapy. In the present review, the potential associations between the gut microbiota, and cancer, host immunity and cancer immunotherapy are reviewed. Furthermore, the effects of fecal microbiota transplantation, antibiotics, probiotics, prebiotics, synbiotics, components of traditional Chinese medicine and various lifestyle factors on the gut microbiota and cancer immunotherapy outcomes are discussed. Certain dominant bacterial groups in the context of cancer immunotherapy and certain effective methods for optimizing immunotherapy by regulating the gut microbiota have been identified. Further investigation may enable the rapid conversion of these discoveries into practical products and clinically applicable methods.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yang H, Wang D and Wang X: Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review). Oncol Lett 20: 342, 2020.
APA
Wang, J., Yang, H., Wang, D., & Wang, X. (2020). Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review). Oncology Letters, 20, 342. https://doi.org/10.3892/ol.2020.12205
MLA
Wang, J., Yang, H., Wang, D., Wang, X."Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)". Oncology Letters 20.6 (2020): 342.
Chicago
Wang, J., Yang, H., Wang, D., Wang, X."Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)". Oncology Letters 20, no. 6 (2020): 342. https://doi.org/10.3892/ol.2020.12205
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Yang H, Wang D and Wang X: Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review). Oncol Lett 20: 342, 2020.
APA
Wang, J., Yang, H., Wang, D., & Wang, X. (2020). Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review). Oncology Letters, 20, 342. https://doi.org/10.3892/ol.2020.12205
MLA
Wang, J., Yang, H., Wang, D., Wang, X."Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)". Oncology Letters 20.6 (2020): 342.
Chicago
Wang, J., Yang, H., Wang, D., Wang, X."Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors (Review)". Oncology Letters 20, no. 6 (2020): 342. https://doi.org/10.3892/ol.2020.12205
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