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Article Open Access

Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study

  • Authors:
    • Saroj Kumar Das Majumdar
    • Sundaram Subramanian
    • Ghanashyam Biswas
    • Nisarg Joshi
    • Mujtaba A. Khan
    • Imran Ahmad
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, All India Institute of Medical Sciences, Bhubaneswar, Odisha 751019, India, Department of Medical Oncology, VS Hospital, Madras Cancer Institute, Advanced Cancer Care, Chennai, Tamil Nadu 600031, India, Department of Medical Oncology, Sparsh Hospital, Bhubaneswar, Odisha 751007, India, Department of Medical Affairs and Clinical Development, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380054, India, Jina Pharmaceuticals Inc., Libertyville, IL 60048, USA
    Copyright: © Majumdar et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 344
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    Published online on: October 8, 2020
       https://doi.org/10.3892/ol.2020.12207
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Abstract

Squamous cell carcinoma of the head and neck (SCCHN) is the most common cancer in Indian men. Docetaxel alone or in combination with other chemotherapeutic agents is recommended for the management of SCCHN. The present multicenter, retrospective study was conducted to evaluate the efficacy and safety of a novel docetaxel formulation ‘nanosomal docetaxel lipid suspension (NDLS)’‑based chemotherapy in SCCHN. The medical records of patients with SCCHN, who were treated with NDLS‑based chemotherapy and followed up between August 2014 and September 2018, were reviewed. The efficacy endpoints were overall response rate [ORR; complete response (CR) + partial response (PR)] and disease control rate (DCR; CR + PR + stable disease) for patients receiving NDLS‑based induction or palliative chemotherapy. Overall survival (OS) and safety were also evaluated. Efficacy evaluation was available in 30/34 patients (induction, 20/23; palliative, 10/11). NDLS‑based induction chemotherapy showed an ORR and DCR of 95% and a median OS of 43.5 months (follow‑up duration, 0.6‑80.3 months). For NDLS‑based palliative chemotherapy, the ORR and DCR were 50% and the median OS time was 4.6 months (follow‑up duration, 1.8 to 14.3 months). At least one adverse event was reported in 82.6% patients. No new safety concerns were reported. Overall, NDLS‑based chemotherapy was effective and well tolerated in the treatment of SCCHN.
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Copy and paste a formatted citation
Spandidos Publications style
Majumdar SK, Subramanian S, Biswas G, Joshi N, Khan MA and Ahmad I: Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study. Oncol Lett 20: 344, 2020.
APA
Majumdar, S.K., Subramanian, S., Biswas, G., Joshi, N., Khan, M.A., & Ahmad, I. (2020). Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study. Oncology Letters, 20, 344. https://doi.org/10.3892/ol.2020.12207
MLA
Majumdar, S. K., Subramanian, S., Biswas, G., Joshi, N., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study". Oncology Letters 20.6 (2020): 344.
Chicago
Majumdar, S. K., Subramanian, S., Biswas, G., Joshi, N., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study". Oncology Letters 20, no. 6 (2020): 344. https://doi.org/10.3892/ol.2020.12207
Copy and paste a formatted citation
x
Spandidos Publications style
Majumdar SK, Subramanian S, Biswas G, Joshi N, Khan MA and Ahmad I: Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study. Oncol Lett 20: 344, 2020.
APA
Majumdar, S.K., Subramanian, S., Biswas, G., Joshi, N., Khan, M.A., & Ahmad, I. (2020). Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study. Oncology Letters, 20, 344. https://doi.org/10.3892/ol.2020.12207
MLA
Majumdar, S. K., Subramanian, S., Biswas, G., Joshi, N., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study". Oncology Letters 20.6 (2020): 344.
Chicago
Majumdar, S. K., Subramanian, S., Biswas, G., Joshi, N., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension‑based chemotherapy in squamous cell carcinoma of the head and neck: A multicenter retrospective study". Oncology Letters 20, no. 6 (2020): 344. https://doi.org/10.3892/ol.2020.12207
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