Thyroid paraganglioma accompanied by lymph node metastasis or trachea invasion: A case report

Yu,Xing; Wang,Yong; Xie,Qiuping; Yan,Haichao; Zhao,Qunzi; Xiang,Cheng; Zhang,Maolin; Li,Jin-Fan; Wang,Ping

doi:10.3892/ol.2020.12208

December-2020 Volume 20 Issue 6

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December-2020 Volume 20 Issue 6

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Case Report Open Access

Thyroid paraganglioma accompanied by lymph node metastasis or trachea invasion: A case report

Authors:
- Xing Yu
- Yong Wang
- Qiuping Xie
- Haichao Yan
- Qunzi Zhao
- Cheng Xiang
- Maolin Zhang
- Jin-Fan Li
- Ping Wang
View Affiliations / Copyright

Affiliations: Department of Thyroid Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China, Department of Pathology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China

Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 345
|
Published online on: October 8, 2020

https://doi.org/10.3892/ol.2020.12208
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Abstract

Thyroid paraganglioma (TP) is an uncommon neuroendocrine tumor with potential for misdiagnosis. Case 1 (male; 44 years old) presented with hoarseness for 3 months. A 2.5‑cm gray nodule in the left thyroid was diagnosed as TP by immunohistochemistry. Lymph node metastasis was confirmed by H&E staining and immunohistochemistry. The patient was followed‑up for 3 years without any signs of recurrence or metastasis. Case 2 (female; 39 years old) presented with an asymptomatic but rapidly growing thyroid nodule. The patient underwent thyroidectomy 8 years ago (2008) and was diagnosed with TP postoperatively. The patient was diagnosed with recurrence and exhibited trachea invasion. Thyroidectomy and partial trachea resection were performed. A literature review revealed that 62 other cases of TP have been reported, and most of them exhibited low malignant potential. However, the two cases presented in the current case report exhibited a high malignant potential, accompanied by lymph node metastasis or trachea invasion, and these features imply that the choice of treatment for patients should be based on their different degrees of malignancy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Thyroid paraganglioma accompanied by lymph node metastasis or trachea invasion: A case report

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