Open Access

Identification of AK4 as a novel therapeutic target for serous ovarian cancer

  • Authors:
    • Minmin Huang
    • Xinlei Qin
    • Yuwei Wang
    • Furong Mao
  • View Affiliations

  • Published online on: October 8, 2020     https://doi.org/10.3892/ol.2020.12209
  • Article Number: 346
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to assess the expression level of adenylate kinase 4 (AK4) in human serous ovarian cancer (SOC) tissues and investigate the possible involvement of AK4 in SOC progression. Bioinformatics analysis based on The Cancer Genome Atlas (TCGA) database and immunohistochemical (IHC) assays were performed to assess the expression level of AK4 in human SOC tissues. Clinical pathological features of patients with SOC were also evaluated. Colony formation, MTT, wound healing and Transwell assays were conducted to investigate the effects of AK4 on the proliferation, migration, and invasion of SOC cells in vitro. Mouse xenograft and lung metastasis models were developed to evaluate the effects of AK4 on tumor growth and metastasis in vivo. High expression levels of AK4 were identified in human SOC tissues compared with in normal tissues according to TCGA database and the results of IHC assays. A contribution of AK4 to tumor growth and metastasis of SOC cells in vivo was also shown. The present study confirmed the involvement of AK4 in the progression of SOC, and the results indicated that AK4 could serve as a novel therapeutic target for SOC treatment.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Huang M, Qin X, Wang Y and Mao F: Identification of AK4 as a novel therapeutic target for serous ovarian cancer. Oncol Lett 20: 346, 2020
APA
Huang, M., Qin, X., Wang, Y., & Mao, F. (2020). Identification of AK4 as a novel therapeutic target for serous ovarian cancer. Oncology Letters, 20, 346. https://doi.org/10.3892/ol.2020.12209
MLA
Huang, M., Qin, X., Wang, Y., Mao, F."Identification of AK4 as a novel therapeutic target for serous ovarian cancer". Oncology Letters 20.6 (2020): 346.
Chicago
Huang, M., Qin, X., Wang, Y., Mao, F."Identification of AK4 as a novel therapeutic target for serous ovarian cancer". Oncology Letters 20, no. 6 (2020): 346. https://doi.org/10.3892/ol.2020.12209