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Identification of AK4 as a novel therapeutic target for serous ovarian cancer

  • Authors:
    • Minmin Huang
    • Xinlei Qin
    • Yuwei Wang
    • Furong Mao
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu 222023, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 346
    |
    Published online on: October 8, 2020
       https://doi.org/10.3892/ol.2020.12209
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Abstract

The present study aimed to assess the expression level of adenylate kinase 4 (AK4) in human serous ovarian cancer (SOC) tissues and investigate the possible involvement of AK4 in SOC progression. Bioinformatics analysis based on The Cancer Genome Atlas (TCGA) database and immunohistochemical (IHC) assays were performed to assess the expression level of AK4 in human SOC tissues. Clinical pathological features of patients with SOC were also evaluated. Colony formation, MTT, wound healing and Transwell assays were conducted to investigate the effects of AK4 on the proliferation, migration, and invasion of SOC cells in vitro. Mouse xenograft and lung metastasis models were developed to evaluate the effects of AK4 on tumor growth and metastasis in vivo. High expression levels of AK4 were identified in human SOC tissues compared with in normal tissues according to TCGA database and the results of IHC assays. A contribution of AK4 to tumor growth and metastasis of SOC cells in vivo was also shown. The present study confirmed the involvement of AK4 in the progression of SOC, and the results indicated that AK4 could serve as a novel therapeutic target for SOC treatment.
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1 

Gutiérrez-Castañeda LD, Tovar-Parra D, Quintero G, Amezquita L, Guerrero C and Sanabria D: Isolation and phenotypic characterization of tumor cells of patients with a diagnosis of ovarian cancer. J Cell Physiol. 235:3320–3328. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Antar A, AlJawad H, AlMuslim A and El-Majzoub N: Isolated late recurrence of epithelial ovarian cancer in cervical lymph nodes. Eur J Gynaecological Oncol. 40:1067–1069. 2019.

3 

Bouberhan S, Shea M and Cannistra SA: Advanced epithelial ovarian cancer: Do more options mean greater benefits? J Clin Oncol. 37:1359–1364. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Zuberi M, Mir R, Khan I, Javid J, Guru SA, Bhat M, Sumi MP, Ahmad I, Masroor M, Yadav P, et al: The promising signatures of circulating microRNA-145 in epithelial ovarian cancer patients. MicroRNA. 9:49–57. 2019. View Article : Google Scholar

5 

Lalremmawia H and Tiwary BK: Identification of molecular biomarkers for ovarian cancer using computational approaches. Carcinogenesis. 40:742–748. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Ida T, Fujiwara H, Kiriu T, Taniguchi Y and Kohyama A: Relationship between the precursors of high grade serous ovarian cancer and patient characteristics: Decreased incidence of the p53 signature in pregnant women. J Gynecol Oncol. 30:e962019. View Article : Google Scholar : PubMed/NCBI

7 

Kreuzinger C, von der Decken I, Wolf A, Gamperl M, Koller J, Karacs J, Pfaffinger S, Bartl T, Reinthaller A, Grimm C, et al: Patient-derived cell line models revealed therapeutic targets and molecular mechanisms underlying disease progression of high grade serous ovarian cancer. Cancer Lett. 459:1–12. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Clifford C, Vitkin N, Nersesian S, Reid-Schachter G, Francis JA and Koti M: Multi-omics in high-grade serous ovarian cancer: Biomarkers from genome to the immunome. Am J Reprod Immunol. 80:e129752018. View Article : Google Scholar : PubMed/NCBI

9 

Gadducci A, Guarneri V, Peccatori FA, Ronzino G, Scandurra G, Zamagni C, Zola P and Salutari V: Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status. J Ovarian Res. 12:92019. View Article : Google Scholar : PubMed/NCBI

10 

Ivy SP, Kunos CA, Arnaldez FI and Kohn EC: Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints. Expert Opin Investig Drugs. 28:771–785. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Song K, Wang Y, Li Y, Ding C, Cai R, Tao G, Zhao P, Xia Q and He H: A convenient, rapid, sensitive, and reliable spectrophotometric assay for adenylate kinase activity. Molecules. 24:6632019. View Article : Google Scholar

12 

Liu R, Ström AL, Zhai J, Gal J, Bao S, Gong W and Zhu H: Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase. Int J Biochem Cell Biol. 41:1371–1380. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Yoneda T, Sato M, Maeda M and Takagi H: Identification of a novel adenylate kinase system in the brain: Cloning of the fourth adenylate kinase. Brain Res Mol Brain Res. 62:187–195. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Panayiotou C, Solaroli N, Johansson M and Karlsson A: Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4. Int J Biochem Cell Biol. 42:62–69. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Miyoshi K, Akazawa Y, Horiguchi T and Noma T: Localization of adenylate kinase 4 in mouse tissues. Acta Histochem Cytochem. 42:55–64. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Kong F, Binas B, Moon JH, Kang SS and Kim HJ: Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells. Arch Biochem Biophys. 533:11–17. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Jan YH, Tsai HY, Yang CJ, Huang MS, Yang YF, Lai TC, Lee CH, Jeng YM, Huang CY, Su JL, et al: Adenylate kinase-4 is a marker of poor clinical outcomes that promotes metastasis of lung cancer by downregulating the transcription factor ATF3. Cancer Res. 72:5119–5129. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Jan YH, Lai TC, Yang CJ, Huang MS and Hsiao M: A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma. Sci Rep. 9:123292019. View Article : Google Scholar : PubMed/NCBI

19 

Jan YH, Lai TC, Yang CJ, Lin YF, Huang MS and Hsiao M: Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis. J Hematol Oncol. 12:122019. View Article : Google Scholar : PubMed/NCBI

20 

Xin F, Yao DW, Fan L, Liu JH and Liu XD: Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion. Clin Exp Med. 19:525–534. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Zang C, Zhao F, Hua L and Pu Y: The miR-199a-3p regulates the radioresistance of esophageal cancer cells via targeting the AK4 gene. Cancer Cell Int. 18:1862018. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Yang Y, Zhao Z, Xie C and Zhao Y: Dual-targeting liposome modified by glutamic hexapeptide and folic acid for bone metastatic breast cancer. Chem Phys Lipids. 228:1048822020. View Article : Google Scholar : PubMed/NCBI

24 

Zhao Z, Zhao Y, Xie C, Chen C, Lin D, Wang S, Lin D, Cui X, Guo Z and Zhou J: Dual-active targeting liposomes drug delivery system for bone metastatic breast cancer: Synthesis and biological evaluation. Chem Phys Lipids. 223:1047852019. View Article : Google Scholar : PubMed/NCBI

25 

Yamamoto TM, McMellen A, Watson ZL, Aguilera J, Ferguson R, Nurmemmedov E, Thakar T, Moldovan GL, Kim H, Cittelly DM, et al: Activation of Wnt signaling promotes olaparib resistant ovarian cancer. Mol Carcinog. 58:1770–1782. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Secord AA, McCollum M, Davidson BA, Broadwater G, Squatrito R, Havrilesky LJ, Gabel AC, Starr MD, Brady JC, Nixon AB and Duska LR: Phase II trial of nintedanib in patients with bevacizumab-resistant recurrent epithelial ovarian, tubal, and peritoneal cancer. Gynecol Oncol. 153:555–561. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Lichtenfels R, Dressler SP, Zobawa M, Recktenwald CV, Ackermann A, Atkins D, Kersten M, Hesse A, Puttkammer M, Lottspeich F and Seliger B: Systematic comparative protein expression profiling of clear cell renal cell carcinoma: A pilot study based on the separation of tissue specimens by two-dimensional gel electrophoresis. Mol Cell Proteomics. 8:2827–2842. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Fujisawa K, Terai S, Takami T, Yamamoto N, Yamasaki T, Matsumoto T, Yamaguchi K, Owada Y, Nishina H, Noma T and Sakaida I: Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4. J Exp Clin Cancer Res. 35:482016. View Article : Google Scholar : PubMed/NCBI

29 

Lei W, Yan C, Ya J, Yong D, Yujun B and Kai L: MiR-199a-3p affects the multi-chemoresistance of osteosarcoma through targeting AK4. BMC Cancer. 18:6312018. View Article : Google Scholar : PubMed/NCBI

30 

Ji Y, Yang C, Tang Z, Yang Y, Tian Y, Yao H, Zhu X, Zhang Z, Ji J and Zheng X: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Nat Commun. 8:153082017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang M, Qin X, Wang Y and Mao F: Identification of AK4 as a novel therapeutic target for serous ovarian cancer. Oncol Lett 20: 346, 2020.
APA
Huang, M., Qin, X., Wang, Y., & Mao, F. (2020). Identification of AK4 as a novel therapeutic target for serous ovarian cancer. Oncology Letters, 20, 346. https://doi.org/10.3892/ol.2020.12209
MLA
Huang, M., Qin, X., Wang, Y., Mao, F."Identification of AK4 as a novel therapeutic target for serous ovarian cancer". Oncology Letters 20.6 (2020): 346.
Chicago
Huang, M., Qin, X., Wang, Y., Mao, F."Identification of AK4 as a novel therapeutic target for serous ovarian cancer". Oncology Letters 20, no. 6 (2020): 346. https://doi.org/10.3892/ol.2020.12209
Copy and paste a formatted citation
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Spandidos Publications style
Huang M, Qin X, Wang Y and Mao F: Identification of AK4 as a novel therapeutic target for serous ovarian cancer. Oncol Lett 20: 346, 2020.
APA
Huang, M., Qin, X., Wang, Y., & Mao, F. (2020). Identification of AK4 as a novel therapeutic target for serous ovarian cancer. Oncology Letters, 20, 346. https://doi.org/10.3892/ol.2020.12209
MLA
Huang, M., Qin, X., Wang, Y., Mao, F."Identification of AK4 as a novel therapeutic target for serous ovarian cancer". Oncology Letters 20.6 (2020): 346.
Chicago
Huang, M., Qin, X., Wang, Y., Mao, F."Identification of AK4 as a novel therapeutic target for serous ovarian cancer". Oncology Letters 20, no. 6 (2020): 346. https://doi.org/10.3892/ol.2020.12209
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