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MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1

  • Authors:
    • Lin-Ya Yao
    • Jun Ma
    • Xue-Ming Zeng
    • Jun Ou‑yang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Urology, Kunshan Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Kunshan, Jiangsu 215300, P.R. China
    Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 353
    |
    Published online on: October 11, 2020
       https://doi.org/10.3892/ol.2020.12215
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Abstract

The aim of the present study was to determine the effect of microRNA (miR)‑155‑5p on the expression of testican‑1 (SPOCK1) and the invasion and migration of prostate cancer cells in vitro. Bioinformatics analysis and molecular biology assays revealed that SPOCK1 may be a direct target gene of miR‑155‑5p. In addition, a negative correlation was identified between SPCOK1 and miR‑155‑5p expression in prostate tumor tissues and cell lines. miR‑155‑5p mimic transfection inhibited SPOCK1 expression in PC3 cells and decreased cell migration and invasion abilities, while the expression of vimentin, N‑cadherin, E‑cadherin, β‑catenin, matrix metalloproteinase (MMP)3 and MMP9 was upregulated. In summary, SPOCK1 was found to be a target gene of miR155‑5p in prostate cancer, and miR‑155‑5p acts as a tumor‑suppressor gene and may inhibit SPOCK1‑mediated prostate cancer progression.
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Copy and paste a formatted citation
Spandidos Publications style
Yao L, Ma J, Zeng X and Ou‑yang J: MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1. Oncol Lett 20: 353, 2020.
APA
Yao, L., Ma, J., Zeng, X., & Ou‑yang, J. (2020). MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1. Oncology Letters, 20, 353. https://doi.org/10.3892/ol.2020.12215
MLA
Yao, L., Ma, J., Zeng, X., Ou‑yang, J."MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1". Oncology Letters 20.6 (2020): 353.
Chicago
Yao, L., Ma, J., Zeng, X., Ou‑yang, J."MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1". Oncology Letters 20, no. 6 (2020): 353. https://doi.org/10.3892/ol.2020.12215
Copy and paste a formatted citation
x
Spandidos Publications style
Yao L, Ma J, Zeng X and Ou‑yang J: MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1. Oncol Lett 20: 353, 2020.
APA
Yao, L., Ma, J., Zeng, X., & Ou‑yang, J. (2020). MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1. Oncology Letters, 20, 353. https://doi.org/10.3892/ol.2020.12215
MLA
Yao, L., Ma, J., Zeng, X., Ou‑yang, J."MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1". Oncology Letters 20.6 (2020): 353.
Chicago
Yao, L., Ma, J., Zeng, X., Ou‑yang, J."MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1". Oncology Letters 20, no. 6 (2020): 353. https://doi.org/10.3892/ol.2020.12215
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