Open Access

Coiled‑coil domain‑containing 68 promotes non‑small cell lung cancer cell proliferation in vitro

  • Authors:
    • Tao Hua
    • Jie Ding
    • Jialing Xu
    • Yu Fan
    • Zejie Liu
    • Juanwen Lian
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  • Published online on: October 14, 2020     https://doi.org/10.3892/ol.2020.12220
  • Article Number: 356
  • Copyright: © Hua et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Coiled‑coil domain‑containing 68 (CCDC68) is a novel secretory protein that acts as a tumor suppressor gene in several types of malignant tumors. However, the role of CCDC68 in the development of lung cancer has not been extensively studied. In the present study, to explore the biological functions of CCDC68 in NSCLC, we performed cell proliferation, viability and apoptosis assays on human lung cancer cell lines upon CCDC68 gene silencing with short hairpin RNA. The results demonstrated that following knockdown of CCDC68 expression, cell proliferation was decreased and the apoptotic rates were increased in A549 and H1299 cells. The role and mechanism of CCDC68 in malignant tumors, particularly in lung cancer, should be further explored, and CCDC68 may serve as a novel target for treatment of lung cancer.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hua T, Ding J, Xu J, Fan Y, Liu Z and Lian J: Coiled‑coil domain‑containing 68 promotes non‑small cell lung cancer cell proliferation <em>in&nbsp;vitro</em>. Oncol Lett 20: 356, 2020
APA
Hua, T., Ding, J., Xu, J., Fan, Y., Liu, Z., & Lian, J. (2020). Coiled‑coil domain‑containing 68 promotes non‑small cell lung cancer cell proliferation <em>in&nbsp;vitro</em>. Oncology Letters, 20, 356. https://doi.org/10.3892/ol.2020.12220
MLA
Hua, T., Ding, J., Xu, J., Fan, Y., Liu, Z., Lian, J."Coiled‑coil domain‑containing 68 promotes non‑small cell lung cancer cell proliferation <em>in&nbsp;vitro</em>". Oncology Letters 20.6 (2020): 356.
Chicago
Hua, T., Ding, J., Xu, J., Fan, Y., Liu, Z., Lian, J."Coiled‑coil domain‑containing 68 promotes non‑small cell lung cancer cell proliferation <em>in&nbsp;vitro</em>". Oncology Letters 20, no. 6 (2020): 356. https://doi.org/10.3892/ol.2020.12220