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Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma

  • Authors:
    • Ozge Sukruoglu Erdogan
    • Seref Bugra Tuncer
    • Seda Kilic
    • Demet Akdeniz Odemis
    • Gozde Kuru Turkcan
    • Betul Celik
    • Mukaddes Avsar
    • Hulya Yazici
  • View Affiliations / Copyright

    Affiliations: Department of Basic Oncology, Cancer Genetics Division, Institute of Oncology, Istanbul University, Istanbul 34093, Turkey
    Copyright: © Erdogan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 357
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    Published online on: October 14, 2020
       https://doi.org/10.3892/ol.2020.12221
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Abstract

Ovarian cancer is a disease that is generally diagnosed at an advanced stage, and has poor survival. Monozygotic (MZ) twins are considered to be good research models for investigating the epigenetic changes associated with diseases. In the present study, the involvement of epigenetic mechanisms in ovarian cancer etiology were evaluated using the MZ twin model. Whole‑genome methylation patterns were investigated in a BRCA1 gene mutation‑carrying family comprising MZ twins, only one of whom had ovarian cancer, and other healthy siblings. Whole‑genome methylation patterns were assessed in peripheral blood DNA using Infinium MethylationEPIC BeadChips on an Illumina iScan device. The hypermethylated and hypomethylated genes were detected between cases and controls in four different comparison groups in order to evaluate the differences in methylation levels according to cancer diagnosis and BRCA mutation status. The obtained results showed that the differential methylations in 12 different genes, namely PR/SET domain 6, cytochrome B5 reductase 4, ZNF714, OR52M1, SEMA4D, CHD1L, CAPZB, clustered mitochondria homolog, RB‑binding protein 7, chromatin repair factor, ankyrin repeat domain 23, RIB43A domain with coiled‑coils 1 and C6orf227, were associated with ovarian cancer. Biological functional analysis of the genes detected in the study using the PANTHER classification system revealed that they have roles in biological processes including ‘biologic adhesion’, ‘regulation’, ‘cellular components organization’, ‘biogenesis’, ‘immune system functioning’, ‘metabolic functioning’ and ‘localization’. Overall, the present study suggested that epigenetic differences, such as methylation status, could be used as a non‑invasive biological markers for the early diagnosis and follow‑up of ovarian cancer.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Noone AM, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, et al: SEER Cancer statistics review. National Cancer Institute Bethesda; MD: 1975-2015

3 

Yancik R: Ovarian cancer. Age contrasts in incidence, histology, disease stage at diagnosis, and mortality. Cancer. 71:517–523. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Kurman RJ: Origin and molecular pathogenesis of ovarian high-grade serous carcinoma. Ann Oncol. 24 (Suppl 10):x16–x21. 2013. View Article : Google Scholar : PubMed/NCBI

5 

US Preventive Services Task Force, ; Bibbins-Domingo K, Grossman DC, Curry SJ, Barry MJ, Davidson KW, Doubeni CA, Epling JW Jr, García FA, Kemper AR, et al: Screening for gynecologic conditions with pelvic examination: US preventive services task force recommendation statement. JAMA. 317:947–953. 2017. View Article : Google Scholar : PubMed/NCBI

6 

La Vecchia C: Ovarian cancer: Epidemiology and risk factors. Eur J Cancer Prev. 26:55–62. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Whittemore AS, Harris R and Itnyre J: Characteristics relating to ovarian cancer risk: Collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women. Collaborative Ovarian Cancer Group. Am J Epidemiol. 136:1184–1203. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Pharoah PD, Day NE, Duffy S, Easton DF and Ponder BA: Family history and the risk of breast cancer: A systematic review and meta-analysis. Int J Cancer. 71:800–809. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Crum CP, Drapkin R, Miron A, Ince TA, Muto M, Kindelberger DW and Lee Y: The distal fallopian tube: A new model for pelvic serous carcinogenesis. Curr Opin Obstet Gynecol. 19:3–9. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Kurman RJ and McConnell TG: Characterization and comparison of precursors of ovarian and endometrial carcinoma: Parts I and II. Int J Surg Pathol. 18 (Suppl 3):S181–S189. 2010. View Article : Google Scholar

11 

Mutch D, Denny L and Quinn M; FIGO Committee on Gynecologic Oncology, : Hereditary gynecologic cancers. Int J Gynaecol Obstet. 124:189–192. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Wolffe AP and Matzke MA: Epigenetics: Regulation through repression. Science. 286:481–486. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Chatterjee A and Morison IM: Monozygotic twins: Genes are not the destiny? Bioinformation. 7:369–370. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Ready K, Litton JK and Arun BK: Clinical application of breast cancer risk assessment models. Future Oncol. 6:355–365. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Petronis A, Gottesman II, Kan P, Kennedy JL, Basile VS, Paterson AD and Popendikyte V: Monozygotic twins exhibit numerous epigenetic differences: Clues to twin discordance? Schizophr Bull. 29:169–178. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Wong AH, Gottesman II and Petronis A: Phenotypic differences in genetically identical organisms: The epigenetic perspective. Hum Mol Genet 14 Spec No. 1:R11–R18. 2005. View Article : Google Scholar

17 

Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, et al: Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA. 102:10604–10609. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Heijmans BT, Kremer D, Tobi EW, Boomsma DI and Slagboom PE: Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet. 16:547–554. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GH, Wong AH, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C, et al: DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet. 41:240–245. 2009. View Article : Google Scholar : PubMed/NCBI

20 

The Helsinki Declaration of the World Medical Association (WMA): Ethical principles of medical research involving human subjects. Pol Merkur Lekarski. 36:298–301. 2014.(In Polish). PubMed/NCBI

21 

Pidsley R, Zotenko E, Peters TJ, Lawrence MG, Risbridger GP, Molloy P, Van Djik S, Muhlhausler B, Stirzaker C and Clark SJ: Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling. Genome Biol. 17:2082016. View Article : Google Scholar : PubMed/NCBI

22 

Teschendorff AE, Marabita F, Lechner M, Bartlett T, Tegner J, Gomez-Cabrero D and Beck S: A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics. 29:189–196. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Du P, Zhang X, Huang CC, Jafari N, Kibbe WA, Hou L and Lin SM: Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics. 11:5872010. View Article : Google Scholar : PubMed/NCBI

24 

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, et al: A human protein-protein interaction network: A resource for annotating the proteome. Cell. 122:957–968. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Thomas PD, Kejariwal A, Campbell MJ, Mi H, Diemer K, Guo N, Ladunga I, Ulitsky-Lazareva B, Muruganujan A, Rabkin S, et al: PANTHER: A browsable database of gene products organized by biological function, using curated protein family and subfamily classification. Nucleic Acids Res. 31:334–341. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Jones PA and Baylin SB: The epigenomics of cancer. Cell. 128:683–692. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Zheng M, Hu Y, Gou R, Wang J, Nie X, Li X, Liu Q, Liu J and Lin B: Integrated multi-omics analysis of genomics, epigenomics, and transcriptomics in ovarian carcinoma. Aging (Albany NY). 11:4198–4215. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Maldonado L and Hoque MO: Epigenomics and ovarian carcinoma. Biomark Med. 4:543–570. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Davis CA, Haberland M, Arnold MA, Sutherland LB, McDonald OG, Richardson JA, Childs G, Harris S, Owens GK and Olson EN: PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 26:2626–2636. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Yarden RI and Brody LC: BRCA1 interacts with components of the histone deacetylase complex. Proc Natl Acad Sci USA. 96:4983–4988. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Yu N, Zhang P, Wang L, He XJ, Yang SS and Lu HJ: RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma. Oncol Lett. 16:7204–7211. 2018.PubMed/NCBI

33 

Xu M, Wang W, Frontera JR, Neely MC, Lu J, Aires D, Hsu FF, Turk J, Swerdlow RH, Carlson SE and Zhu H: Ncb5or deficiency increases fatty acid catabolism and oxidative stress. J Biol Chem. 286:11141–11154. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Chen Y, Zhang L, Liu WX and Wang K: VEGF and SEMA4D have synergistic effects on the promotion of angiogenesis in epithelial ovarian cancer. Cell Mol Biol Lett. 23:22018. View Article : Google Scholar : PubMed/NCBI

35 

He WP, Zhou J, Cai MY, Xiao XS, Liao YJ, Kung HF, Guan XY, Xie D and Yang GF: CHD1L Protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival. BMC Cancer. 12:4372012. View Article : Google Scholar : PubMed/NCBI

36 

Hall E, Volkov P, Dayeh T, Esguerra JL, Salö S, Eliasson L, Rönn T, Bacos K and Ling C: Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets. Genome Biol. 15:5222014. View Article : Google Scholar : PubMed/NCBI

37 

Chen B and Li CW: Big Mechanisms of aging via system ıdentification and big database mining. Big Mechanisms in Systems Biology. Elsevıer; pp. 671–735. 2017, View Article : Google Scholar

38 

Peters KM, Edwards SL, Nair SS, French JD, Bailey PJ, Salkield K, Stein S, Wagner S, Francis GD, Clark SJ and Brown MA: Androgen receptor expression predicts breast cancer survival: The role of genetic and epigenetic events. BMC Cancer. 12:1322012. View Article : Google Scholar : PubMed/NCBI

39 

Rizzolo P, Silvestri V, Valentini V, Zelli V, Zanna I, Masala G, Bianchi S, Palli D and Ottini L: Gene-specific methylation profiles in BRCA-mutation positive and BRCA-mutation negative male breast cancers. Oncotarget. 9:19783–19792. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Erdogan OS, Tuncer SB, Kilic S, Odemis DA, Turkcan GK, Celik B, Avsar M and Yazici H: Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma. Oncol Lett 20: 357, 2020.
APA
Erdogan, O.S., Tuncer, S.B., Kilic, S., Odemis, D.A., Turkcan, G.K., Celik, B. ... Yazici, H. (2020). Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma. Oncology Letters, 20, 357. https://doi.org/10.3892/ol.2020.12221
MLA
Erdogan, O. S., Tuncer, S. B., Kilic, S., Odemis, D. A., Turkcan, G. K., Celik, B., Avsar, M., Yazici, H."Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma". Oncology Letters 20.6 (2020): 357.
Chicago
Erdogan, O. S., Tuncer, S. B., Kilic, S., Odemis, D. A., Turkcan, G. K., Celik, B., Avsar, M., Yazici, H."Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma". Oncology Letters 20, no. 6 (2020): 357. https://doi.org/10.3892/ol.2020.12221
Copy and paste a formatted citation
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Spandidos Publications style
Erdogan OS, Tuncer SB, Kilic S, Odemis DA, Turkcan GK, Celik B, Avsar M and Yazici H: Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma. Oncol Lett 20: 357, 2020.
APA
Erdogan, O.S., Tuncer, S.B., Kilic, S., Odemis, D.A., Turkcan, G.K., Celik, B. ... Yazici, H. (2020). Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma. Oncology Letters, 20, 357. https://doi.org/10.3892/ol.2020.12221
MLA
Erdogan, O. S., Tuncer, S. B., Kilic, S., Odemis, D. A., Turkcan, G. K., Celik, B., Avsar, M., Yazici, H."Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma". Oncology Letters 20.6 (2020): 357.
Chicago
Erdogan, O. S., Tuncer, S. B., Kilic, S., Odemis, D. A., Turkcan, G. K., Celik, B., Avsar, M., Yazici, H."Genome‑wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma". Oncology Letters 20, no. 6 (2020): 357. https://doi.org/10.3892/ol.2020.12221
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