MicroRNA‑454‑3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin‑like growth factor 2 mRNA‑binding protein 1
- Aiting Yan
- Cuizhu Wang
- Liangfeng Zheng
- Jiebo Zhou
- Yan Zhang
Affiliations: Department of Oncology, Affiliated Haian Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China, Central Laboratory, Affiliated Haian Hospital of Nantong University, Nantong, Jiangsu 226600, P.R. China
- Published online on: October 14, 2020 https://doi.org/10.3892/ol.2020.12223
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Esophageal cancer (ESCA) is the eighth most common cause of cancer‑associated mortality in humans. An increasing number of studies have demonstrated that microRNAs (miRs) serve important roles in mediating tumor initiation and progression. miR‑454‑3p has been found to be involved in the development of various human malignancies; however, little is known about the role of miR‑454‑3p in esophageal cancer. In the present study, the protein and gene expression levels of miR‑454‑3p in ESCA tissues and cells were downregulated compared with adjacent normal tissues and normal human esophageal epithelial cells. Additionally, miR‑454‑3p downregulation resulted in improved survival rates in patients with ESCA, and miR‑454‑3p overexpression significantly suppressed cell proliferation, migration and invasion and promoted apoptosis in four ESCA cell lines (EC9706, ECA109, TE‑1 and TE‑8). It was found that miR‑454‑3p overexpression inhibited the expression of insulin‑like growth factor 2 mRNA‑binding protein 1 (IGF2BP1) at the protein and mRNA expression levels. Furthermore, it was demonstrated that miR‑454‑3p inhibited ESCA cell proliferation, migration and apoptosis by targeting IGF2BP1 via the ERK and AKT signaling pathways in a subcutaneous xenograft tumor mouse model. These results showed that miR‑454‑3p functioned as an important tumor suppressor in ESCA by targeting IGFBP1. Therefore, miR‑454‑3p may be a novel prognostic biomarker and therapeutic target for patients with ESCA.