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MicroRNA‑454‑3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin‑like growth factor 2 mRNA‑binding protein 1

  • Authors:
    • Aiting Yan
    • Cuizhu Wang
    • Liangfeng Zheng
    • Jiebo Zhou
    • Yan Zhang

  • View Affiliations

  • Published online on: October 14, 2020     https://doi.org/10.3892/ol.2020.12223
  • Article Number: 359

  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Esophageal cancer (ESCA) is the eighth most common cause of cancer‑associated mortality in humans. An increasing number of studies have demonstrated that microRNAs (miRs) serve important roles in mediating tumor initiation and progression. miR‑454‑3p has been found to be involved in the development of various human malignancies; however, little is known about the role of miR‑454‑3p in esophageal cancer. In the present study, the protein and gene expression levels of miR‑454‑3p in ESCA tissues and cells were downregulated compared with adjacent normal tissues and normal human esophageal epithelial cells. Additionally, miR‑454‑3p downregulation resulted in improved survival rates in patients with ESCA, and miR‑454‑3p overexpression significantly suppressed cell proliferation, migration and invasion and promoted apoptosis in four ESCA cell lines (EC9706, ECA109, TE‑1 and TE‑8). It was found that miR‑454‑3p overexpression inhibited the expression of insulin‑like growth factor 2 mRNA‑binding protein 1 (IGF2BP1) at the protein and mRNA expression levels. Furthermore, it was demonstrated that miR‑454‑3p inhibited ESCA cell proliferation, migration and apoptosis by targeting IGF2BP1 via the ERK and AKT signaling pathways in a subcutaneous xenograft tumor mouse model. These results showed that miR‑454‑3p functioned as an important tumor suppressor in ESCA by targeting IGFBP1. Therefore, miR‑454‑3p may be a novel prognostic biomarker and therapeutic target for patients with ESCA.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yan A, Wang C, Zheng L, Zhou J and Zhang Y: MicroRNA‑454‑3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin‑like growth factor 2 mRNA‑binding protein 1. Oncol Lett 20: 359, 2020
APA
Yan, A., Wang, C., Zheng, L., Zhou, J., & Zhang, Y. (2020). MicroRNA‑454‑3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin‑like growth factor 2 mRNA‑binding protein 1. Oncology Letters, 20, 359. https://doi.org/10.3892/ol.2020.12223
MLA
Yan, A., Wang, C., Zheng, L., Zhou, J., Zhang, Y."MicroRNA‑454‑3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin‑like growth factor 2 mRNA‑binding protein 1". Oncology Letters 20.6 (2020): 359.
Chicago
Yan, A., Wang, C., Zheng, L., Zhou, J., Zhang, Y."MicroRNA‑454‑3p inhibits cell proliferation and invasion in esophageal cancer by targeting insulin‑like growth factor 2 mRNA‑binding protein 1". Oncology Letters 20, no. 6 (2020): 359. https://doi.org/10.3892/ol.2020.12223