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Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production

  • Authors:
    • Yi-Bin Zhao
    • Shao-Hui Yang
    • Jie Shen
    • Ke Deng
    • Qi Li
    • Yu Wang
    • Wei Cui
    • Hua Ye
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Ningbo Medical Treatment Center, Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 360
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    Published online on: October 14, 2020
       https://doi.org/10.3892/ol.2020.12224
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Abstract

Research on the immunosuppression of cancer cells has attracted much attention in recent years. The present study sought to provide a new strategy for tumor immunotherapy targeting mast cells by studying the mechanisms underlying mast cell function in cancer immunosuppression. Between January 2015 and December 2017, the tumor tissues of 40 patients with gastric cancer (GC) were collected and grouped in Lihuili Hospital of Ningbo City, China. Pathological sections were prepared and an immunofluorescence assay was performed to analyze the expression of forkhead Box Protein P3 (FOXP3), tryptase, TGFβ1, TGF‑βR, IL‑9, IL‑9R and Oxford 40 ligand (OX40L). Then, the correlations between FOXP3 and tryptase, TGFβ1 and tryptase expression, and the expression of OX40L in patients with GC with different stages were analyzed. The results revealed that high levels of mast cells were present in patients GC, and tryptase and FOXP3 expressions were positively correlated. Mast cells regulate T regulatory (reg) cells in the gastric tumor microenvironment by secreting TGFβ1. Tregs, in turn, promote the survival of mast cells in the tumor microenvironment by producing IL‑9. Furthermore, OX40L expression in mast cells was significantly associated with Tumor‑Node‑Metastasis staging of GC. Overall, the present study reported a positive feedback system that functions through TGFβ1 and IL‑9 to allow cross‑talk between Tregs and mast cells. Moreover, OX40L may be a potential target for the diagnosis and treatment of GC. These results may provide a new strategy for tumor immunotherapy targeting mast cells.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Yang S, Shen J, Deng K, Li Q, Wang Y, Cui W and Ye H: Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production. Oncol Lett 20: 360, 2020.
APA
Zhao, Y., Yang, S., Shen, J., Deng, K., Li, Q., Wang, Y. ... Ye, H. (2020). Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production. Oncology Letters, 20, 360. https://doi.org/10.3892/ol.2020.12224
MLA
Zhao, Y., Yang, S., Shen, J., Deng, K., Li, Q., Wang, Y., Cui, W., Ye, H."Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production". Oncology Letters 20.6 (2020): 360.
Chicago
Zhao, Y., Yang, S., Shen, J., Deng, K., Li, Q., Wang, Y., Cui, W., Ye, H."Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production". Oncology Letters 20, no. 6 (2020): 360. https://doi.org/10.3892/ol.2020.12224
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Yang S, Shen J, Deng K, Li Q, Wang Y, Cui W and Ye H: Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production. Oncol Lett 20: 360, 2020.
APA
Zhao, Y., Yang, S., Shen, J., Deng, K., Li, Q., Wang, Y. ... Ye, H. (2020). Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production. Oncology Letters, 20, 360. https://doi.org/10.3892/ol.2020.12224
MLA
Zhao, Y., Yang, S., Shen, J., Deng, K., Li, Q., Wang, Y., Cui, W., Ye, H."Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production". Oncology Letters 20.6 (2020): 360.
Chicago
Zhao, Y., Yang, S., Shen, J., Deng, K., Li, Q., Wang, Y., Cui, W., Ye, H."Interaction between regulatory T cells and mast cells via IL‑9 and TGF‑β production". Oncology Letters 20, no. 6 (2020): 360. https://doi.org/10.3892/ol.2020.12224
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