Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells
- Takefumi Doi
- Hiroyuki Ogawa
- Yugo Tanaka
- Yoshitake Hayashi
- Yoshimasa Maniwa
Affiliations: Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan, Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Hyogo 673‑8558, Japan, Division of Molecular Medicine and Medical Genetics, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan
- Published online on: October 14, 2020 https://doi.org/10.3892/ol.2020.12226
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Invasion has a significant role in cancer progression, including expansion to surrounding tissue and metastasis. Previously, we assessed the invasive ability of cancer cells using an easy‑to‑prepare double‑layered collagen gel hemisphere (DL‑CGH) method by which cancer cell invasion can be easily visualized. The present study examined multiple lung adenocarcinoma and malignant pleural mesothelioma (MPM) cell lines using the DL‑CGH method and identified inherently invasive cell lines. Next, by comparing gene expression between invasive and non‑invasive cells by cDNA microarray, the potential candidate gene brain‑expressed x‑linked protein 1 (Bex1) was identified to be involved in cancer invasion, as it was highly expressed in the invasive cell lines. Downregulation of Bex1 suppressed the invasion and proliferation of the invasive tumor cell lines. The findings of the present study suggested that Bex1 may promote metastasis in vivo and could be a potential oncogene and molecular therapeutic target in lung adenocarcinoma and MPM.