Open Access

Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells

  • Authors:
    • Takefumi Doi
    • Hiroyuki Ogawa
    • Yugo Tanaka
    • Yoshitake Hayashi
    • Yoshimasa Maniwa
  • View Affiliations

  • Published online on: October 14, 2020     https://doi.org/10.3892/ol.2020.12226
  • Article Number: 362
  • Copyright: © Doi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Invasion has a significant role in cancer progression, including expansion to surrounding tissue and metastasis. Previously, we assessed the invasive ability of cancer cells using an easy‑to‑prepare double‑layered collagen gel hemisphere (DL‑CGH) method by which cancer cell invasion can be easily visualized. The present study examined multiple lung adenocarcinoma and malignant pleural mesothelioma (MPM) cell lines using the DL‑CGH method and identified inherently invasive cell lines. Next, by comparing gene expression between invasive and non‑invasive cells by cDNA microarray, the potential candidate gene brain‑expressed x‑linked protein 1 (Bex1) was identified to be involved in cancer invasion, as it was highly expressed in the invasive cell lines. Downregulation of Bex1 suppressed the invasion and proliferation of the invasive tumor cell lines. The findings of the present study suggested that Bex1 may promote metastasis in vivo and could be a potential oncogene and molecular therapeutic target in lung adenocarcinoma and MPM.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Doi T, Ogawa H, Tanaka Y, Hayashi Y and Maniwa Y: <em>Bex1</em> significantly contributes to the proliferation and invasiveness of malignant tumor cells. Oncol Lett 20: 362, 2020
APA
Doi, T., Ogawa, H., Tanaka, Y., Hayashi, Y., & Maniwa, Y. (2020). <em>Bex1</em> significantly contributes to the proliferation and invasiveness of malignant tumor cells. Oncology Letters, 20, 362. https://doi.org/10.3892/ol.2020.12226
MLA
Doi, T., Ogawa, H., Tanaka, Y., Hayashi, Y., Maniwa, Y."<em>Bex1</em> significantly contributes to the proliferation and invasiveness of malignant tumor cells". Oncology Letters 20.6 (2020): 362.
Chicago
Doi, T., Ogawa, H., Tanaka, Y., Hayashi, Y., Maniwa, Y."<em>Bex1</em> significantly contributes to the proliferation and invasiveness of malignant tumor cells". Oncology Letters 20, no. 6 (2020): 362. https://doi.org/10.3892/ol.2020.12226