Open Access

The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma

  • Authors:
    • Feng Zhong
    • Hui-Ping Lu
    • Gang Chen
    • Yi-Wu Dang
    • Xiao-Guohui Zhang
    • Yao Liang
    • Ming-Xuan Li
    • Guo-Sheng Li
    • Xiao-Yi Chen
    • Yu-Xuan Yao
    • Yong-Ying Qin
    • Miao Mo
    • Kai-Lang Zhang
    • Hua Ding
    • Zhi-Guang Huang
    • Zhu-Xin Wei
  • View Affiliations

  • Published online on: October 22, 2020     https://doi.org/10.3892/ol.2020.12240
  • Article Number: 377
  • Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Approximately 500,000 new head and neck squamous cell carcinoma (HNSCC) cases are detected every year around the world, and its incidence ranks sixth among all cancer types globally. Among these cases, oral squamous cell carcinoma (OSCC) and laryngeal squamous cell carcinoma (LSCC) are HNSCC subtypes with high incidence rates, especially in China. The present study examines the association between the apolipoprotein L1 (APOL1) mRNA and protein expression and clinical parameters in HNSCC. The two most common types (oral and larynx) of HNSCC were selected for subgroup analyses. Immunohistochemistry (IHC) was used to detect APOL1 protein expression levels in HNSCC clinical specimens. It was demonstrated that APOL1 protein expression in 221 cases of HNSCC was higher compared with that in normal tissues. Consistent upregulation of APOL1 protein was also found in subgroups of OSCC and LSCC. Through mining the ArrayExpress, The Cancer Genome Atlas and the Gene Expression Omnibus databases, microarrays and RNA sequencing data for HNSCC were retrieved, which were used to analyze APOL1 mRNA expression levels. The results showed that APOL1 expression was higher in both OSCC and LSCC subtypes, as well as in HNSCC, compared with that in non‑cancerous squamous epithelium. The summary receiver operating characteristic analysis showed that APOL1 had potential as a diagnostic biomarker for HNSCC, OSCC and LSCC. Thus, upregulation of APOL1 may contribute to the tumorigenesis of HNSCC.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhong F, Lu H, Chen G, Dang Y, Zhang X, Liang Y, Li M, Li G, Chen X, Yao Y, Yao Y, et al: The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma. Oncol Lett 20: 377, 2020
APA
Zhong, F., Lu, H., Chen, G., Dang, Y., Zhang, X., Liang, Y. ... Wei, Z. (2020). The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma. Oncology Letters, 20, 377. https://doi.org/10.3892/ol.2020.12240
MLA
Zhong, F., Lu, H., Chen, G., Dang, Y., Zhang, X., Liang, Y., Li, M., Li, G., Chen, X., Yao, Y., Qin, Y., Mo, M., Zhang, K., Ding, H., Huang, Z., Wei, Z."The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma". Oncology Letters 20.6 (2020): 377.
Chicago
Zhong, F., Lu, H., Chen, G., Dang, Y., Zhang, X., Liang, Y., Li, M., Li, G., Chen, X., Yao, Y., Qin, Y., Mo, M., Zhang, K., Ding, H., Huang, Z., Wei, Z."The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma". Oncology Letters 20, no. 6 (2020): 377. https://doi.org/10.3892/ol.2020.12240