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Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1

  • Authors:
    • Xiaobing Cai
    • Wenyu Xiao
    • Juexin Shen
    • Hui Lian
    • Yi Lu
    • Xianmiao Liu
    • Jisheng Gu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Chongming Branch of Tongji Univercity Affiliated the Tenth People's Hospital, Shanghai 202157, P.R. China, Department of Orthopedics, Jiangwan Hospital, Shanghai 200434, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 391
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    Published online on: October 29, 2020
       https://doi.org/10.3892/ol.2020.12254
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Abstract

Osteosarcoma is a common primary bone cancer that there are currently no effective treatment strategies for. Forkhead box M1 (FoxM1) is key in the development of osteosarcoma, and microRNA (miR)‑216b serves an antitumor role by targeting FoxM1. Moreover, thiostrepton (TST), a natural thiazole antibiotic, induces antitumor effects and specifically targets FoxM1. Therefore, the present study investigated whether thiostrepton and miR‑216b synergistically inhibited osteosarcoma cells by targeting FoxM1. The MTT assay, reverse transcription‑quantitative PCR, a dual‑luciferase reporter assay and flow cytometry were performed. Compared with the human osteoblast cell line hFOB1.19, miR‑216b expression was significantly downregulated in the osteosarcoma cell lines U2OS, MG63 and Saos‑2. By contrast, FoxM1 expression was significantly upregulated in osteosarcoma cell lines compared with the hFOB1.19 cell line. The results indicated that miR‑216b targeted the 3'‑untranslated region of FoxM1. Moreover, the results suggested that miR‑216b cooperated with TST to decrease cell cytotoxicity and increase cell apoptosis. In addition, miR‑216b cooperated with TST to increase Bax expression and decrease Bcl‑2 expression. In conclusion, the combination of TST and miR‑216b synergistically promoted osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1. Therefore, the present study suggested that the combination of TST and miR‑216b may serve as a promising therapeutic strategy for osteosarcoma.
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1 

Wu J, Sun H, Li J, Guo Y, Zhang K, Lang C, Zou C and Ma H: Increased survival of patients aged 0–29 years with osteosarcoma: A period analysis, 1984–2013. Cancer Med. 7:3652–3661. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Hattinger CM, Patrizio MP, Magagnoli F, Luppi S and Serra M: An update on emerging drugs in osteosarcoma: Towards tailored therapies? Expert Opin Emerg Drug. 24:153–171. 2019. View Article : Google Scholar

3 

Inui M, Martello G and Piccolo S: MicroRNA control of signal transduction. Nat Rev Mol Cell Biol. 11:252–263. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Li Q, Wang M, Wang N, Wang J, Qi L and Mao P: Downregulation of microRNA-216b contributes to glioma cell growth and migration by promoting AEG-1-mediated signaling. Biomed Pharmacother. 104:420–426. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Azevedo-Pouly AC, Sutaria DS, Jiang J, Elgamal OA, Amari F, Allard D, Grippo PJ, Coppola V and Schmittgen TD: miR-216 and miR-217 expression is reduced in transgenic mouse models of pancreatic adenocarcinoma, knockout of miR-216/miR-217 host gene is embryonic lethal. Funct Integr Genomics. 17:203–212. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Jana S, Sengupta S, Biswas S, Chatterjee A, Roy H and Bhattacharyya A: miR-216b suppresses breast cancer growth and metastasis by targeting SDCBP. Biochem Biophys Res Commun. 482:126–133. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Chen X, Zhang L, Song Q and Chen Z: MicroRNA-216b regulates cell proliferation, invasion and cycle progression via interaction with cyclin T2 in gastric cancer. Anticancer Drugs. 31:623–631. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Wang W, Guo Z, Yu H and Fan L: miR-216b inhibits osteosarcoma cell proliferation, migration, and invasion by targeting Forkhead Box M1. J Cell Biochem. 120:5435–5443. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Zheng WW, Zhou J, Zhang CH and Liu XS: MicroRNA-216b is downregulated in hepatocellular carcinoma and inhibits HepG2 cell growth by targeting Forkhead box protein M1. Eur Rev Med Pharmacol Sci. 20:2541–2550. 2016.PubMed/NCBI

10 

He S, Liao B, Deng Y, Su C, Tuo J, Liu J, Yao S and Xu L: miR-216b inhibits cell proliferation by targeting FOXM1 in cervical cancer cells and is associated with better prognosis. BMC Cancer. 17:6732017. View Article : Google Scholar : PubMed/NCBI

11 

Sandu C, Ngounou Wetie AG, Darie CC and Steller H: Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: A proteomics investigation. Adv Exp Med Biol. 806:443–451. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kwok JM, Myatt SS, Marson CM, Coombes RC, Constantinidou D and Lam EW: Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol Cancer Ther. 7:2022–2032. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Kongsema M, Wongkhieo S, Khongkow M, Lam EW, Boonnoy P, Vongsangnak W and Wong-Ekkabut J: Molecular mechanism of Forkhead box M1 inhibition by thiostrepton in breast cancer cells. Oncol Rep. 42:953–962. 2019.PubMed/NCBI

14 

Huang TH, Wu ATH, Cheng TS, Lin KT, Lai CJ, Hsieh HW, Chang PM, Wu CW, Huang CF and Chen KY: In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non-small-cell lung cancer. J Cell Mol Med. 23:8184–8195. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Kalathil D, Prasad M, Chelladurai M, John S and Nair AS: Thiostrepton degrades mutant p53 by eliciting an autophagic response in SW480 cells. J Cell Physiol. 233:6938–6950. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Maekawa A, Kohashi K, Kuda M, Iura K, Ishii T, Endo M, Nakatsura T, Iwamoto Y and Oda Y: Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas. BMC Cancer. 16:5112016. View Article : Google Scholar : PubMed/NCBI

17 

Christensen L, Joo J, Lee S, Wai D, Triche TJ and May WA: FOXM1 is an oncogenic mediator in Ewing Sarcoma. PLoS One. 8:e545562013. View Article : Google Scholar : PubMed/NCBI

18 

Sengupta A, Rahman M, Mateo-Lozano S, Tirado OM and Notario V: The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma. Int J Oncol. 43:803–812. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Palmerini E, Torricelli E, Cascinu S, Pierini M, De Paolis M, Donati D, Cesari M, Longhi A, Abate M, Paioli A, et al: Is there a role for chemotherapy after local relapse in high-grade osteosarcoma? Pediatr Blood Cancer. 66:e277922019. View Article : Google Scholar : PubMed/NCBI

21 

Li W and Zhang S: Survival of patients with primary osteosarcoma and lung metastases. J BUON. 23:1500–1504. 2018.PubMed/NCBI

22 

Grimer RJ, Taminiau AM and Cannon SR; Surgical Subcommitte of the European Osteosarcoma Intergroup, : Surgical outcomes in osteosarcoma. J Bone Joint Surg Br. 84:395–400. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Wang JY, Yang Y, Ma Y, Wang F, Xue A, Zhu J, Yang H, Chen Q, Chen M, Ye L, et al: Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma. Biomed Pharmacother. 121:1096272020. View Article : Google Scholar : PubMed/NCBI

24 

Rickel K, Fang F and Tao J: Molecular genetics of osteosarcoma. Bone. 102:69–79. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Laoukili J, Stahl M and Medema RH: FoxM1: At the crossroads of ageing and cancer. Biochim Biophys Acta. 1775:92–102. 2007.PubMed/NCBI

26 

Pilarsky C, Wenzig M, Specht T, Saeger HD and Grutzmann R: Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia. 6:744–750. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Gentles AJ, Newman AM, Liu CL, Bratman SV, Feng W, Kim D, Nair VS, Xu Y, Khuong A, Hoang CD, et al: The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med. 21:938–945. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Halasi M and Gartel AL: FOX(M1) news-it is cancer. Mol Cancer Ther. 12:245–254. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Gartel AL: FOXM1 in cancer: Interactions and vulnerabilities. Cancer Res. 77:3135–3139. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Bhat UG, Jagadeeswaran R, Halasi M and Gartel AL: Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells. J Biol Chem. 286:41425–41433. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Umeh-Garcia M, Simion C, Ho PY, Batra N, Berg AL, Carraway KL, Yu A and Sweeney C: A Novel bioengineered miR-127 prodrug suppresses the growth and metastatic potential of triple-negative breast cancer cells. Cancer Res. 80:418–429. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Gong HL, Tao Y, Mao XZ, Song DY, You D and Ni JD: MicroRNA-29a suppresses the invasion and migration of osteosarcoma cells by regulating the SOCS1/NF-κB signalling pathway through negatively targeting DNMT3B. Int J Mol Med. 44:1219–1232. 2019.PubMed/NCBI

33 

Patil SL, Palat A, Pan Y, Rajapakshe K, Mirchandani R, Bondesson M, Yustein JT, Coarfa C and Gunaratne PH: MicroRNA-509-3p inhibits cellular migration, invasion, and proliferation, and sensitizes osteosarcoma to cisplatin. Sci Rep. 9:190892019. View Article : Google Scholar : PubMed/NCBI

34 

Chen D, Liu D and Chen Z: Potential therapeutic implications of miRNAs in osteosarcoma chemotherapy. Tumour Biol. 39:10104283177057622017. View Article : Google Scholar : PubMed/NCBI

35 

Jana S, Krishna M, Singhal J, Horne D, Awasthi S, Salgia R and Singhal SS: Therapeutic targeting of miRNA-216b in cancer. Cancer Lett. 484:16–28. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Wu X, Chen W, Cai H, Hu J, Wu B, Jiang Y, Chen X, Sun D and An Y: miR-216b inhibits pancreatic cancer cell progression and promotes apoptosis by down-regulating KRAS. Arch Med Sci. 14:1321–1332. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Wang Y, Dong D, Jiang S, Zhang E, Zheng W, Mao L, Li W, Zhou J, Fan L, Cheng R, et al: miR-216b post-transcriptionally downregulates oncogene KRAS and inhibits cell proliferation and invasion in clear cell renal cell carcinoma. Cell Physiol Biochem. 49:1755–1765. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Chen X, Liu X, He B, Pan Y, Sun H, Xu T, Hu X and Wang S: miR-216b functions as a tumor suppressor by targeting HMGB1-mediated JAK2/STAT3 signaling way in colorectal cancer. Am J Cancer Res. 7:2051–2069. 2017.PubMed/NCBI

39 

Wang L, Wang Y, Du X, Yao Y, Wang L and Jia Y: miR-216b suppresses cell proliferation, migration, invasion, and epithelial-mesenchymal transition by regulating FOXM1 expression in human non-small cell lung cancer. Onco Targets Ther. 12:2999–3009. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Liu S, Dong H, Dai H, Liu D and Wang Z: MicroRNA-216b regulated proliferation and invasion of non-small cell lung cancer by targeting SOX9. Oncol Lett. 15:10077–10083. 2018.PubMed/NCBI

41 

Zheng L, Zhang X, Yang F, Zhu J, Zhou P, Yu F, Hou L, Xiao L, He Q and Wang B: Regulation of the P2X7R by microRNA-216b in human breast cancer. Biochem Biophys Res Commun. 452:197–204. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Bhat UG, Halasi M and Gartel AL: FoxM1 is a general target for proteasome inhibitors. PLoS One. 4:e65932009. View Article : Google Scholar : PubMed/NCBI

43 

Hegde NS, Sanders DA, Rodriguez R and Balasubramanian S: The transcription factor FOXM1 is a cellular target of the natural product thiostrepton. Nat Chem. 3:725–731. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Gartel AL: Thiostrepton, proteasome inhibitors and FOXM1. Cell Cycle. 10:4341–4342. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Koo CY, Muir KW and Lam EW: FOXM1: From cancer initiation to progression and treatment. Biochim Biophys Acta. 1819:28–37. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Ahmed M, Uddin S, Hussain AR, Alyan A, Jehan Z, Al-Dayel F, Al-Nuaim A, Al-Sobhi S, Amin T, Bavi P and Al-Kuraya KS: FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma. J Clin Endocrinol Metab. 97:E1–E13. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Halasi M, Schraufnagel DP and Gartel AL: Wild-type p53 protects normal cells against apoptosis induced by thiostrepton. Cell Cycle. 8:2850–2851. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Wang M and Gartel AL: Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts. Mol Cancer Res. 10:2287–2297. 2011.

49 

Kwok JM, Peck B, Monteiro LJ, Schwenen HD, Millour J, Coombes RC, Myatt SS and Lam EW: FOXM1 confers acquired cisplatin resistance in breast cancer cells. Mol Cancer Res. 8:24–34. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Wang M and Gartel AL: Combination with bortezomib enhances the antitumor effects of nanoparticle-encapsulated thiostrepton. Cancer Biol Ther. 13:184–189. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Jin P, Chen X, Yu G, Li Z, Zhang Q and Zhang JV: The clinical and experimental research on the treatment of endometriosis with thiostrepton. Anticancer Agents Med Chem. 19:323–329. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Jiang L, Wu X, Wang P, Wen T, Yu C, Wei L and Chen H: Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. J Cancer Res Clin Oncol. 141:971–981. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cai X, Xiao W, Shen J, Lian H, Lu Y, Liu X and Gu J: Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1. Oncol Lett 20: 391, 2020.
APA
Cai, X., Xiao, W., Shen, J., Lian, H., Lu, Y., Liu, X., & Gu, J. (2020). Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1. Oncology Letters, 20, 391. https://doi.org/10.3892/ol.2020.12254
MLA
Cai, X., Xiao, W., Shen, J., Lian, H., Lu, Y., Liu, X., Gu, J."Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1". Oncology Letters 20.6 (2020): 391.
Chicago
Cai, X., Xiao, W., Shen, J., Lian, H., Lu, Y., Liu, X., Gu, J."Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1". Oncology Letters 20, no. 6 (2020): 391. https://doi.org/10.3892/ol.2020.12254
Copy and paste a formatted citation
x
Spandidos Publications style
Cai X, Xiao W, Shen J, Lian H, Lu Y, Liu X and Gu J: Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1. Oncol Lett 20: 391, 2020.
APA
Cai, X., Xiao, W., Shen, J., Lian, H., Lu, Y., Liu, X., & Gu, J. (2020). Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1. Oncology Letters, 20, 391. https://doi.org/10.3892/ol.2020.12254
MLA
Cai, X., Xiao, W., Shen, J., Lian, H., Lu, Y., Liu, X., Gu, J."Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1". Oncology Letters 20.6 (2020): 391.
Chicago
Cai, X., Xiao, W., Shen, J., Lian, H., Lu, Y., Liu, X., Gu, J."Thiostrepton and miR‑216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1". Oncology Letters 20, no. 6 (2020): 391. https://doi.org/10.3892/ol.2020.12254
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