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Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)

  • Authors:
    • Zheng-Bin Huang
    • Hai-Tao Zhang
    • Benjamin Yu
    • De-Hua Yu
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Hanchuan Renmin Hospital, Hanchuan, Hubei 431600, P.R. China, Department of Gastrointestinal Surgery, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong 518037, P.R. China, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA, Shenzhen USK Bioscience Co., Ltd., Shenzhen, Guangdong 518110, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 3
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    Published online on: November 3, 2020
       https://doi.org/10.3892/ol.2020.12264
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Abstract

Gastric cancer (GC) is one of the most common malignant tumors with poor prognosis worldwide, mainly due to the lack of suitable modalities for population‑based screening and early detection of this disease. Therefore, novel and less invasive tests with improved clinical utility are urgently required. The remarkable advances in genomics and proteomics, along with emerging new technologies for highly sensitive detection of genetic alterations, have shown the potential to map the genomic makeup of a tumor in liquid biopsies, in order to assist with early detection and clinical management. The present review summarize the current status in the identification and development of cell‑free DNA (cfDNA)‑based biomarkers in GC, and also discusses their potential utility and the technical challenges in developing practical cfDNA‑based liquid biopsy for early detection of GC.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Zhang H, Yu B and Yu D: Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review). Oncol Lett 21: 3, 2021.
APA
Huang, Z., Zhang, H., Yu, B., & Yu, D. (2021). Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review). Oncology Letters, 21, 3. https://doi.org/10.3892/ol.2020.12264
MLA
Huang, Z., Zhang, H., Yu, B., Yu, D."Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)". Oncology Letters 21.1 (2021): 3.
Chicago
Huang, Z., Zhang, H., Yu, B., Yu, D."Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)". Oncology Letters 21, no. 1 (2021): 3. https://doi.org/10.3892/ol.2020.12264
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Z, Zhang H, Yu B and Yu D: Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review). Oncol Lett 21: 3, 2021.
APA
Huang, Z., Zhang, H., Yu, B., & Yu, D. (2021). Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review). Oncology Letters, 21, 3. https://doi.org/10.3892/ol.2020.12264
MLA
Huang, Z., Zhang, H., Yu, B., Yu, D."Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)". Oncology Letters 21.1 (2021): 3.
Chicago
Huang, Z., Zhang, H., Yu, B., Yu, D."Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)". Oncology Letters 21, no. 1 (2021): 3. https://doi.org/10.3892/ol.2020.12264
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