Open Access

Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)

  • Authors:
    • Zheng-Bin Huang
    • Hai-Tao Zhang
    • Benjamin Yu
    • De-Hua Yu
  • View Affiliations

  • Published online on: November 3, 2020     https://doi.org/10.3892/ol.2020.12264
  • Article Number: 3
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) is one of the most common malignant tumors with poor prognosis worldwide, mainly due to the lack of suitable modalities for population‑based screening and early detection of this disease. Therefore, novel and less invasive tests with improved clinical utility are urgently required. The remarkable advances in genomics and proteomics, along with emerging new technologies for highly sensitive detection of genetic alterations, have shown the potential to map the genomic makeup of a tumor in liquid biopsies, in order to assist with early detection and clinical management. The present review summarize the current status in the identification and development of cell‑free DNA (cfDNA)‑based biomarkers in GC, and also discusses their potential utility and the technical challenges in developing practical cfDNA‑based liquid biopsy for early detection of GC.
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January-2021
Volume 21 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Huang Z, Zhang H, Yu B and Yu D: Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review). Oncol Lett 21: 3, 2021
APA
Huang, Z., Zhang, H., Yu, B., & Yu, D. (2021). Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review). Oncology Letters, 21, 3. https://doi.org/10.3892/ol.2020.12264
MLA
Huang, Z., Zhang, H., Yu, B., Yu, D."Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)". Oncology Letters 21.1 (2021): 3.
Chicago
Huang, Z., Zhang, H., Yu, B., Yu, D."Cell‑free DNA as a liquid biopsy for early detection of gastric cancer (Review)". Oncology Letters 21, no. 1 (2021): 3. https://doi.org/10.3892/ol.2020.12264